“…Sec16A (hereafter called Sec16) plays an important role in ERES homeostasis as it interacts with several COPII components and regulates their function (Bhattacharyya and Glick, 2007;Connerly et al, 2005;Farhan et al, 2008;Ivan et al, 2008;Supek et al, 2002;Watson et al, 2006;Espenshade et al, 1995;Gimeno et al, 1996;Whittle and Schwartz, 2010;Kung et al, 2012). Various post-translational modifications, such as phosphorylation (Farhan et al, 2010;Koreishi et al, 2013;Lord et al, 2011;Sharpe et al, 2011), ubiquitylation (Jin et al, 2012) or glycosylation (Dudognon et al, 2004), were reported to modulate ER export, but the molecular details and functional consequences of this regulation remain to be established.…”