<i>DRD2</i> methylation is associated with executive control network connectivity and severity of alcohol problems among a sample of polysubstance users

Hagerty, Sarah L.; YorkWilliams, Sophie L.; Bidwell, L. Cinnamon; Weiland, Barbara J.; Sabbineni, Amithrupa; Blaine, Sara K.; Bryan, Angela D.; Hutchison, Kent E.

doi:10.1111/adb.12684

Cited by 17 publications

(9 citation statements)

References 75 publications

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“…In a study comparing the classification capacity of differing imaging modalities, resting state connectivity between networks predicted 33% of the variance of alcohol use severity in adults with problem drinking patters, and outperformed the predictive capacity of structural MRI or task-based functional MRI (monetary incentive delay and face matching) (Fede et al, 2019). Epigenetic factors have also been examined with dopamine receptor D2 methylation associated with severity of alcohol problems and negatively associated with functional connectivity of the executive control network (Hagerty et al, 2018).…”

Section: Resting State Functional Mrimentioning

confidence: 99%

Addictions NeuroImaging Assessment (ANIA): Towards an integrative framework for alcohol use disorder

Voon

Grodin

Mandali

et al. 2020

Neuroscience & Biobehavioral Reviews

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Alcohol misuse and addiction are major international public health issues. Addiction can be characterized as a disorder of aberrant neurocircuitry interacting with environmental, genetic and social factors. Neuroimaging in alcohol misuse can thus provide a critical window into underlying neural mechanisms, highlighting possible treatment targets and acting as clinical biomarkers for predicting risk and treatment outcomes. This neuroimaging review on alcohol misuse in humans follows the Addictions Neuroclinical Assessment (ANA) that proposes incorporating three functional neuroscience domains integral to the neurocircuitry of addiction: incentive salience and habits, negative emotional states, and executive function within the context of the addiction cycle. Here we review and integrate multiple imaging modalities focusing on underlying cognitive processes such as reward anticipation, negative emotionality, cue reactivity, impulsivity, compulsivity and executive function. We highlight limitations in the literature and propose a model forward in the use of neuroimaging as a tool to understanding underlying mechanisms and potential clinical applicability for phenotyping of heterogeneity and predicting risk and treatment outcomes.

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Section: Resting State Functional Mrimentioning

confidence: 99%

Addictions NeuroImaging Assessment (ANIA): Towards an integrative framework for alcohol use disorder

Voon

Grodin

Mandali

et al. 2020

Neuroscience & Biobehavioral Reviews

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“…Therefore, DA function, a key player in both substance abuse and obesity, is reduced [ 9 , 10 ]. RDS manifests as an individual’s neurochemical deficiency at perceiving reward, including DA function deficiency and alterations in reward pathways, resulting in the seeking behavior of alternative ways to promote DA release, such as substance abuse and overeating [ 65 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 80 , 81 , 82 , 83 , 84 , 85 , 86 , 87 , 88 , 89 ], binge eating, etc. [ 90 , 91 , 92 , 93 , 94 , 95 , 96 , 97 , 98 , 99 , 100 , 101 , 102 , 103 , 104 ].…”

Section: Genetic Factors Of Nicotine Use and Obesity Riskmentioning

confidence: 99%

“…An animal study observed hyperphagic behavior and preference for a high-sucrose diet in female rats exposed to nicotine during lactation, coinciding with an increase in protein content of DRD2 in the NAc [ 134 ]. There is also evidence that smoking significantly increases DRD2-gene methylation, which contributes to both substance and non-substance addictions [ 79 , 149 ]. These results continue to further support the role of alterations of DRD2 as part of the mechanism leading to obesity.…”

Section: Genetic Factors Of Nicotine Use and Obesity Riskmentioning

confidence: 99%

Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review

White

Roeder

Blum

et al. 2022

IJERPH

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Nicotine usage by mothers throughout pregnancy has been observed to relate to numerous deleterious effects in children, especially relating to obesity. Children who have prenatally been exposed to nicotine tend to have lower birth weights, with an elevated risk of becoming overweight throughout development and into their adolescent and adult life. There are numerous theories as to how this occurs: catch-up growth theory, thrifty phenotype theory, neurotransmitter or endocrine imbalances theory, and a more recent examination on the genetic factors relating to obesity risk. In addition to the negative effect on bodyweight and BMI, individuals with obesity may also suffer from numerous comorbidities involving metabolic disease. These may include type 1 and 2 diabetes, high cholesterol levels, and liver disease. Predisposition for obesity with nicotine usage may also be associated with genetic risk alleles for obesity, such as the DRD2 A1 variant. This is important for prenatally nicotine-exposed individuals as an opportunity to provide early prevention and intervention of obesity-related risks.

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“…DLGAP2 encodes membrane-associated guanylate kinases relevant for the organization of synapses involved in neuronal cell signaling. In another study, over 400 differentially methylated CpG sites were identified in precuneus brain samples of 49 subjects (11 female) and 47 controls (12 female) [45].…”

Section: Epigenetic Factorsmentioning

confidence: 99%

Prospects of Genetics and Epigenetics of Alcohol Use Disorder

et al. 2020

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Purpose of Review In this study, we illustrate recent findings regarding the genetics and epigenetics of alcohol use disorder (AUD). We further outline the future direction of genetic and epigenetic research in AUD. Recent Findings Recent genome- and epigenome-wide studies allow new insight into genetic and epigenetic variation associated with AUD. The largest EWAS of AUD so far/to date found evidence for altered glucocorticoid receptor regulation. Longitudinal studies provide insight into the dynamics of the disease. Analyses of postmortem brain tissue reveal the impact of chronic alcohol consumption on DNA methylation in the brain. Summary Genetic and environmental factors—mediated via epigenetic mechanisms—play an important role in AUD. Although knowledge of the biological underpinnings of AUD is still limited, ongoing research will ultimately lead to the development of biomarkers for disease classification, course of disease, and treatment response to support personalized medicine in the future.

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DRD2 methylation is associated with executive control network connectivity and severity of alcohol problems among a sample of polysubstance users

Abstract: This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 17 publications

References 75 publications

Addictions NeuroImaging Assessment (ANIA): Towards an integrative framework for alcohol use disorder

Addictions NeuroImaging Assessment (ANIA): Towards an integrative framework for alcohol use disorder

Prenatal Effects of Nicotine on Obesity Risks: A Narrative Review

Prospects of Genetics and Epigenetics of Alcohol Use Disorder

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