Dmd
mdx mice have defective oligodendrogenesis, delayed myelin compaction and persistent hypomyelination
Andrea J. Arreguin,
Zijian Shao,
Holly Colognato
Abstract:Duchenne muscular dystrophy (DMD) is caused by mutations in the DMD gene, resulting in the loss of dystrophin, a large cytosolic protein that links the cytoskeleton to extracellular matrix receptors in skeletal muscle. Aside from progressive muscle damage, many patients with DMD also have neurological deficits of unknown etiology. To investigate potential mechanisms for DMD neurological deficits, we assessed postnatal oligodendrogenesis and myelination in the Dmdmdx mouse model. In the ventricular-subventricul… Show more
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