<i>Dirofilaria immitis</i>in a child from the Russian Federation

Tumolskaya, N. I.; Pozio, Edoardo; Rakova, V M; Supriaga, V G; Сергиев, В П; Morozov, Evgeny N.; Morozova, Lola F.; Rezza, Giovanni; Litvinov, S K

doi:10.1051/parasite/2016037

Cited by 14 publications

(6 citation statements)

References 15 publications

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“…Dirofilaria infection is endemic in Russia. Two species of Dirofilaria ( D. immitis and D. repens ) have been identified in humans [54, 63]. Prior to 2014, D. repens infection was detected in 850 people living permanently in 42 regions of the Russian Federation [54].…”

Section: Introductionmentioning

confidence: 99%

“…Prior to 2014, D. repens infection was detected in 850 people living permanently in 42 regions of the Russian Federation [54]. The first case of D. immitis was detected in 2015 in the Moscow region; an immature female was removed from a 14-month-old child [63]. The dirofilariasis zone in the north of the European part of Russia has advanced to 58° N [4, 10].…”

Section: Introductionmentioning

confidence: 99%

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Dirofilaria and Wolbachia in mosquitoes (Diptera: Culicidae) in central European Russia and on the Black Sea coast

2019

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Dirofilariasis is endemic in Russia, as well as in many other European countries. The aim of this study was to assess the ability of mosquitoes to transfer Dirofilaria immitis and Dirofilaria repens in regions with temperate and subtropical climates. The possible impact of the symbiotic bacterium Wolbachia on Dirofilaria transmission was also investigated. 5333 female mosquitoes were collected at 11 points in central European Russia and on the Black Sea coast during the period 2013–2017. Out of 20 mosquito species examined, 14 were infected with D. repens and 13 with D. immitis. Both species of Dirofilaria were found in different climatic regions. The total Dirofilaria spp. estimated infection rate (EIR) in the central part of Russia varied from 3.1% to 3.7% and, in the southern region, from 1.1% to 3.0%. The highest estimated infection rate was found in Anopheles messeae, the lowest in Culex pipiens. The greatest epidemiological danger was represented by Aedes aegypti, Ae. geniculatus, An. messeae and Ae. communis. Six out of 20 mosquito species were infected with Wolbachia. Pools of Aedes albopictus, Cx. pipiens and Coquillettidia richiardii were simultaneously infected with Dirofilaria and Wolbachia. After checking mosquitoes individually, it was found that there was no development of Dirofilaria to the infective larval stage in specimens infected with Wolbachia. Twenty-two Dirofilaria-infective pools were Wolbachia-free and only two mosquito pools were Wolbachia-infected. The potential for transmission of Dirofilaria in mosquito species naturally uninfected with the symbiotic bacterium Wolbachia is higher than in species infected with the bacterium.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Dirofilaria and Wolbachia in mosquitoes (Diptera: Culicidae) in central European Russia and on the Black Sea coast

2019

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“…В подавляющем большинстве случаев этиологическим фактором дирофиляриоза человека служит D. repens, инвазия человека D. immitis фиксируется крайне редко. Например, в 2016 г. описан случай обнаружения неполовозрелой самки дирофилярии у ребенка 14 мес в Московской области, не выезжавшего за пределы места жительства [20]. При морфологическом исследовании паразит идентифицирован как D. immitis.…”

Section: Discussionunclassified

A case of pleuropulmonary dirofilariasis caused by Dirofilaria repens. Case report

Kozlov,

Ermakova,

Lobzin

et al. 2023

Terapevticheskii arkhiv

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The differential diagnosis of neoplasms of various localizations is the primary task in clinical practice of all physicians. We present a description of the case of invasion with Dirofilaria repens in the lung of a 68-year-old patient. In 2016 the patient was diagnosed with cancer of the left kidney and underwent a left-sided nephrectomy. During the dynamic observation in 2019, a lump was found in the left lung, which was regarded as a metastasis. An atypical SIX resection of the left lung was performed. Microscopy of the removed lump revealed the presence of a nematode of the genus Dirofilaria, presumably D. repens. The species identity of D. repens was confirmed by polymerase chain reaction using species-specific primers. It is known that the morphological identification of parasites up to the species in the surgical material presents certain difficulties and requires high professional training of the researcher. Therefore, the diagnosis of dirofilariasis in atypical localizations of nematodes in the human body is of great importance in the differentiation of malignant and benign formations, and the use of the polymerase chain reaction method can significantly increase the accuracy in establishing the final diagnosis.

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“…These two species are able to cause both pulmonary and extrapulmonary infection. It most commonly occurs in adults between the ages of 21 and 60 years (ESDA), but the case of a 14-month-old child with Dirofilaria in the scrotum region has also been described, which is its most common localization in children [6]. Women are more likely to be infected than men, but without a significant statistical difference.…”

Section: Discussionmentioning

confidence: 99%

“…In many cases, causative therapy is not necessary before the surgery. Tumolskaya et al [6] suggest that the patient should be given a single dose of ivermectin with three doses of diethylcarbamazine if there is a marked suspicion of dirofilariasis.…”

Section: Discussionmentioning

confidence: 99%

Human dirofilariasis

2019

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Introduction Dirofilariasis is a zoonosis caused by nematodes from the genus Dirofilaria, which is a parasite in dogs and other canids, and humans get infected by a mosquito bite. In Europe, the number of patients outside the endemic area is increasing. So far, more than 2,850 cases of human dirofilariasis have been reported worldwide. In the last 20 years, we have had only two confirmed cases in our institution. The disease is manifested in a cutaneous, visceral, and ocular form. From the initial infection, the first symptoms can take several years to manifest. The diagnosis can be confirmed histologically, morphologically, and/or by molecular techniques. The treatment includes surgical removal of the parasite and antiparasitic therapy. Case outline The paper presents two cases of Dirophilaria repens infection. The first patient had a migratory nodular facial skin change for several years. After the skin induration incision in the zygomatic region, a 7-cm-long worm was extracted, later identified as Dirophilaria repens. The pathohistological finding of the extirpated change showed that it was a granuloma inflammation. The second case was a patient with a persistent cough and hemoptysis, with a morphologically verified nodular change in the pulmonary parenchyma. The pathohistological finding of the extirpated change showed a chronic granulomatous inflammation and the presence of parasites. The treatment of both patients resulted in a complete recovery without complications. Conclusion In case of subcutaneous nodules or unclear lung changes, dirofilariasis should be considered. Video-assisted thoracoscopic surgery is the leading diagnostic surgical procedure concerning dirofilariasis, and a significant therapeutic modality.

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Dirofilaria immitisin a child from the Russian Federation

Cited by 14 publications

References 15 publications

Dirofilaria and Wolbachia in mosquitoes (Diptera: Culicidae) in central European Russia and on the Black Sea coast

Dirofilaria and Wolbachia in mosquitoes (Diptera: Culicidae) in central European Russia and on the Black Sea coast

A case of pleuropulmonary dirofilariasis caused by Dirofilaria repens. Case report

Human dirofilariasis

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