Dioscorea bulbiferaMediated Synthesis of Novel Au_coreAg_shellNanoparticles with Potent Antibiofilm and Antileishmanial Activity

Abstract

Dioscorea bulbiferais a potent medicinal plant used in both Indian and Chinese traditional medicine owing to its rich phytochemical diversity. Herein, we report the rapid synthesis of novelAucoreAgshellnanoparticles byD. bulbiferatuber extract (DBTE).AucoreAgshellNPs synthesis was completed within 5 h showing a prominent peak at 540 nm. HRTEM analysis revealed 9 nm inner core of elemental gold covered by a silver shell giving a total particle diameter upto 15 nm.AucoreAgshellNPs were comprised of57.34±1.01% gold and42.66±0.97% silver of the total mass.AucoreAgshellNPs showed highest biofilm inhibition upto83.68±0.09% againstA. baumannii. Biofilms ofP. aeruginosa,E. coli, andS. aureuswere inhibited up to18.93±1.94%,22.33±0.56%, and30.70±1.33%, respectively. Scanning electron microscopy (SEM) and atomic force microscopy (AFM) confirmed unregulated cellular efflux through pore formation leading to cell death. Potent antileishmanial activity ofAucoreAgshellNPs (MIC=32 µg/mL) was confirmed by MTT assay. Further SEM micrographs showed pronounced deformity in the spindle shaped cellular morphology changing to spherical. This is the first report of synthesis, characterization, antibiofilm, and antileishmanial activity ofAucoreAgshellNPs synthesized byD. bulbifera.

Novel platinum–palladium bimetallic nanoparticles synthesized by Dioscorea bulbifera: anticancer and antioxidant activities

“…[24][25][26][27] Similarly, it has been extensively used for synthesis of metal nanoparticles like gold, silver, and gold core silver shell (Au core Ag shell NPs) bimetallic nanoparticles. [28][29][30] Hereby, as a part of our growing interest in nanobiotechnology, herein we report for the first time, the synthesis of Pt-PdNPs by a medicinal plant, D. bulbifera. The bioreduced nanoparticles were further investigated for anticancer and antioxidant activities.…”

Biological Synthesis of Nanoparticles From Medicinal Plants and Its Uses in Inhibiting Biofilm Formation

“…These nanoparticles showed highest biofilm inhibition. This leads to the death of cells [19] (Table 2 and Fig. 5).…”

Gnidia glauca Leaf and Stem Extract Mediated Synthesis of Gold Nanocatalysts with Free Radical Scavenging Potential

“…Attractive crystallographic and morphological characteristics direct the optoelectronics and biological properties [3,4]. Thus nanoparticles with anisotropic properties, particularly gold nanoparticles (AuNPs) have found immense applications in electronics, sensing and medical biotechnology [5,6]. Various chemical methods like wet chemical synthesis, solutions phase methods, reverse micellar or polyol process and template-based methods using nanoporous silica, polycarbonate membranes or carbon nanotubes as well as physical methods like photochemical, microwave assisted, radiolysis and sonochemistry mediated synthesis of metal and metal oxide nanoparticles are available [7][8][9][10][11][12].…”