Dendrobium moniliforme Attenuates High-Fat Diet-Induced Renal Damage in Mice through the Regulation of Lipid-Induced Oxidative Stress

Abstract

Obesity is an important and preventable risk factor for renal disease. The administration of an antioxidant with a lipid-lowering effect is an important therapeutic approach for kidney disease in obese patients. The present study was conducted to examine whether methanolic extract of Dendrobium moniliforme (DM), one of the most famous traditional medicines used in many parts of the world, has an antioxidant effect in vitro and an ameliorative effect on high-fat diet (HFD)-induced alterations such as renal dysfunction and lipid accumulation in vivo. The 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity of DM extract (IC(50) = 29.6 μg/mL) was increased in a dose-dependent manner. The LLC-PK1 kidney cell damage induced by oxidative stress was significantly inhibited by the treatments with DM extract. In the animal study, DM extract (200 mg/kg) was orally administered every day for nine weeks to HFD-fed mice, and its effect was compared with that of metformin. The administration of DM extract decreased the elevated serum glucose, total cholesterol concentration and renal lipid accumulation in HFD-fed mice. It also ameliorated renal dysfunction biomarkers including serum creatinine and renal collagen IV deposition. Taken together, these results provide important evidence that DM extract exhibits a pleiotropic effect on obesity induced parameters and exerted a renoprotective effect in HFD-fed mice.

Proximal Tubular Cannabinoid-1 Receptor Regulates Obesity-Induced CKD

“…[1][2][3] In fact, obese individuals have a greater risk to develop ESRD, 4 especially in combination with diabetes and hypertension, which account for .70% of ESRD. 5,6 Obesity induces hemodynamic and morphologic changes in the kidney, 7 which together with renal inflammation 8 and oxidative stress, 9 may lead to reduced renal function and ultimately, glomerulosclerosis and tubulointerstitial fibrosis. 2,7,10,11 Although multiple metabolic factors have been proposed to contribute to obesity-induced nephropathy, the underlying signaling mechanisms are not completely understood.…”

Rhododendron groenlandicum(Labrador tea), an antidiabetic plant from the traditional pharmacopoeia of the Canadian Eastern James Bay Cree, improves renal integrity in the diet-induced obese mouse model

“…In summary, our study demonstrates that a prolonged intake of HFD, which is accompanied by disturbed glycaemic control (notably increased insulin resistance), can lead to measurable kidney damage (Boini et al 2010;Lee et al 2012;Zhang et al 2012). Treatment with R. groenlandicum, which improved insulin sensitivity in this diet-induced obesity model (Ouchfoun et al 2015), also improves parameters of kidney integrity.…”

Chinese Herbal Medicine for Obesity: A Randomized, Double-Blinded, Multicenter, Prospective Trial

“…Sibutramine increased cardiovascular morbidity as reported by a number of studies including the sibutramine cardiovascular outcomes trial (McDuffie et al, 2002a;James et al, 2010;Curfman et al, 2010;Caterson et al, 2012). Thus, it is important to adopt alternative strategies to identify targets for effective therapeutic interventions, including the use of the TCM herbal medicines (Lee et al, 2012;Zhang et al, 2012;Wang et al, 2013).…”