<i>Demodex</i>
 mites modulate sebocyte immune reaction: possible role in the pathogenesis of rosacea

Lacey, Noreen; Russell‐Hallinan, Adam; Zouboulis, Christos C.; Powell, Frank C.

doi:10.1111/bjd.16540

Cited by 64 publications

(107 citation statements)

References 54 publications

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“…1,2 Although still controversial, [3][4][5] evidence supporting a role of Demodex in papulopustular rosacea (PPR) is accumulating, [6][7][8][9][10] and recent guidelines for the treatment of rosacea include use of ivermectin, an acaricidal drug, as a first-line topical treatment for PPR. 1,2 Although still controversial, [3][4][5] evidence supporting a role of Demodex in papulopustular rosacea (PPR) is accumulating, [6][7][8][9][10] and recent guidelines for the treatment of rosacea include use of ivermectin, an acaricidal drug, as a first-line topical treatment for PPR.…”

Section: Introductionmentioning

confidence: 99%

Treatment of rosacea and demodicosis with benzyl benzoate: effects of different doses on Demodex density and clinical symptoms

Forton¹,

Maertelaer

2019

Acad Dermatol Venereol

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Background Patients with rosacea or demodicosis have high facial skin Demodex densities (Dds). Topical ivermectin, benzyl benzoate (BB) and crotamiton have been shown to decrease Dds in vivo, but there are few data on the clinical and acaricidal effects of BB among patients with rosacea. Objective To evaluate the impact of topical BB (+crotamiton) treatment on Dds and clinical symptoms of rosacea and demodicosis, and compare three BB treatment regimens. Methods In this retrospective observational study, 394 patients (117 with rosacea, 277 with demodicosis) were included. Three BB (+crotamiton) treatment regimens were compared: 12% once daily, 12% twice daily and 20% once daily. Dds were measured using two consecutive standardized skin surface biopsies [superficial (SSSB1) and deep (SSSB2)] before treatment and at the first follow‐up. Symptoms were evaluated using investigator global assessment. Treatment was considered effective if the Dd had normalized (SSSB1 ≤ 5 D/cm2 AND SSSB2 ≤ 10 D/cm²) or symptoms had cleared and curative if the Dd had normalized and symptoms had cleared. Results At an average of 2.7 months after treatment start, the total Dd (SSSB1 + 2) had decreased by 72.4 ± 2.6% from the initial value across the whole cohort. Dds had normalized in 139 patients (35%), and symptoms had cleared in 122 (31%). Treatment was effective in 183 (46%) patients and curative in 78 (20%). Compliance was good: 77% of patients correctly followed treatment instructions. Results were similar in patients with rosacea and those with demodicosis. The 12% once‐daily regimen was less effective than the other doses and had poorer compliance than the 12% twice‐daily regimen. Conclusion Topical treatment with BB (+crotamiton) may be an effective treatment for rosacea and demodicosis, indirectly supporting a key role of the mite in the pathophysiology of rosacea. The two higher dose regimens were more effective than the lower dose.

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Section: Introductionmentioning

confidence: 99%

Treatment of rosacea and demodicosis with benzyl benzoate: effects of different doses on Demodex density and clinical symptoms

Forton¹,

Maertelaer

2019

Acad Dermatol Venereol

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“…In the present study, Demodex infestation was associated with enhanced total blood and skin‐homing T reg cell levels. Accordingly, agents secreted by mites were previously reported to exert immune‐modulating activities and help to avoid induction of host inflammatory mediators . TGF‐β and IL‐10, which are cytokines associated with T reg differentiation and function, were also implicated in canine demodicosis .…”

Section: Discussionmentioning

confidence: 99%

Skin‐homing T‐cell responses associated with Demodex infestation and rosacea

Gazi

Güreser

Öztekin

et al. 2019

Parasite Immunology

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Aims Our aim was to investigate the skin‐homing T‐cell immune responses triggered in patients with Demodex infestation and/or rosacea. Methods Collected whole blood samples were divided into four groups: control subjects; nonrosacea patients with Demodex infestation (Demodex group); papulopustular rosacea (PPR) patients without Demodex infestation (Rosacea group); and PPR patients with Demodex infestation (Rosacea/Demodex group). Following ex vivo activation, skin‐homing CLA+CD4+ T‐cell subset levels were monitored by flow cytometry. Results When compared with control subjects, among skin‐homing CD4+ T‐cell subsets analysed, Demodex patients had higher TH9 and Treg cell levels; Rosacea subjects displayed elevated TH1 cell levels; and Rosacea/Demodex patients exhibited increased frequencies of TH9 and TH22 cells. In contrast to Rosacea subjects, Rosacea/Demodex group members displayed higher TH2 cell levels; and when compared with Demodex groups, they had higher TH1 and TH2 but lower Treg cell levels. Demodex group members also exhibited higher Treg but lower TH1 and TH22 levels than Rosacea/Demodex group subjects. Conclusions The skin‐homing T‐cell responses associated with Demodex infestation and rosacea formation seem to influence each other. The present as well as future studies could contribute to the development of effective treatment strategies for demodicosis and rosacea.

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“…It has been suggested that the inflammatory eruption of Demodex folliculitis is a result of immune reconstitution in post‐HCT patients or those with HIV on antiretroviral therapy . Studies have demonstrated that the mite can stimulate the immune system, resulting in an inflammatory response, which patients are prone to once their immune system is restored . Treatment for Demodex ‐associated dermatitis can be achieved with topical sulfur, permethrin, or ivermectin (either oral or topical) .…”

Section: Discussionmentioning

confidence: 99%

An intensely pruritic eruption following hematopoietic cell transplant

Cardis

Pichard

2019

Pediatric Dermatology

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Demodex mites modulate sebocyte immune reaction: possible role in the pathogenesis of rosacea

Abstract: Demodex mites have the capacity to modulate the TLR signalling pathway of an immortalized human sebocyte line. Mites have the capacity to secrete bioactive molecules that affect the immune reactivity of sebocytes. Increasing mite numbers influenced interleukin-8 secretion by these cells.

Cited by 64 publications

References 54 publications

Treatment of rosacea and demodicosis with benzyl benzoate: effects of different doses on Demodex density and clinical symptoms

Treatment of rosacea and demodicosis with benzyl benzoate: effects of different doses on Demodex density and clinical symptoms

Skin‐homing T‐cell responses associated with Demodex infestation and rosacea

An intensely pruritic eruption following hematopoietic cell transplant

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