<i>De novo</i> annular pustular psoriasis following mRNA COVID‐19 vaccine

Romagnuolo, Maurizio; Pontini, Paolo; Muratori, Simona; Marzano, Angelo Valerio; Moltrasio, Chiara

doi:10.1111/jdv.18114

Cited by 9 publications

(9 citation statements)

References 10 publications

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“…A total of 10 articles were included in this review. Even if several cases of psoriasis exacerbation or new-onset psoriasis have been reported in literature following COVID-19 vaccination, [44][45][46][47][48][49][50][51][52][53] few of these cases have been described in patients undergoing biologic treatment for psoriasis (Table 1). Interestingly, psoriasis flare during biologic treatment have been reported also in patients contracting COVID-19 infection.…”

Section: Resultsmentioning

confidence: 99%

Safety and Efficacy of Covid-19 Vaccination in Patients Undergoing Biological Treatments for Psoriasis

Potestio¹,

Fabbrocini²,

Battista³

et al. 2023

PTT

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The introduction of biologic drugs revolutionized the treatment of psoriasis, shifting treatment goals to higher treatment outcomes and less frequent safety issues. The outbreak of Coronavirus disease 2019 (COVID-19) represented a worldwide challenge, strongly affecting lifestyle, global economy, and overall health. Among the strategies adopted to contain the spreading of the infection, vaccination is the main one. In this context, the introduction of COVID-19 vaccines raised several doubts about their effectiveness and safety in patients undergoing therapy with biological for psoriasis. Even if molecular and cellular mechanisms by which COVID-19 vaccines lead to psoriasis development have not yet been fully elucidated, vaccination itself can trigger the release of interleukin (IL)-6, interferon (IFN) and tumor necrosis factor (TNF) α by T-helper (Th)1/Th17 cells. All these cytokines are involved in psoriasis pathogenesis. Thus, the aim of this manuscript is to review current literature on the safety and effectiveness of COVID-19 vaccination in psoriasis patients undergoing treatment with biologics, in order to clarify any concerns.

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Section: Resultsmentioning

confidence: 99%

Safety and Efficacy of Covid-19 Vaccination in Patients Undergoing Biological Treatments for Psoriasis

Potestio¹,

Fabbrocini²,

Battista³

et al. 2023

PTT

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“…Generalized pustular figurate erythema has been delineated as a distinct entity only recently 3 : indeed, within the 30 cases described to date, 1 , 3 the majority were described as typical or prolonged form of acute generalized exanthematous pustulosis (AGEP) 4 , 5 or as generalized pustular ± annular psoriasis. 6 , 7 , 8 Skin manifestations occur within 20–25 days (while in AGEP within 24–48 h) and tend to respond slowly to corticosteroid therapy.…”

Section: Figurementioning

confidence: 99%

“…On the other hand, COVID‐19 vaccine is likely to induce or exacerbate generalized pustular psoriasis. 6 , 7 , 8 However, further studies on COVID‐19‐positive and COVID‐19‐negative patients are warranted to define the list of GPFE causative agents.…”

Section: Figurementioning

confidence: 99%

“…The identification of those dermoscopic clues-that is tiny pustule surrounded an erythematous halo with evident curved vessels and clods-can be of help in recognizing GPFE cases presenting in late phase and/ or modified by corticosteroid treatment 9 and in differentiating them from a variety of forms which can exhibit overlapping features, including erythema multiforme, AGEP, prolonged/ recalcitrant AGEP, AGEP/SJS overlap and generalized annular pustular psoriasis. [3][4][5][6][7][8] Indeed, in erythema multiforme the clods are reddish-purple in the central dusky zone and reddish in the outer red ring, with linear vessels at the periphery; in AGEP, no distinct vessels are visible around the millimetric pustules; in generalized annular pustular psoriasis the pustules are surrounded by regularly distributed dotted vessels. 10 In our opinion, based on the cases reported to date 1 and on those here presented, GPFE is to be considered as a drugreaction pattern strongly related to the hydroxychloroquine, whereas the role of COVID-19 infection is more likely to be a concomitant association rather than a distinct trigger.…”

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confidence: 99%

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Authors' reply to: ‘Generalized pustular figurate erythema first report in two COVID‐19 patients on hydroxychloroquine’

Bertello

Rubegni

et al. 2022

Acad Dermatol Venereol

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“…Main Cutaneous Reaction Following COVID-19 Vaccination Ouni et al24 (2), Nagrani et al35 (1), Song et al46 (1), Frioui et al49 (1), Cortonesi et al50 (1), Lehmann et al51 (1), Elamin et al52 (1), Wei et al53 (1), Lamberti et al54 (1), Romagnuolo et al25 (1), Ruggiero et al26 (1), Ricardo et al27 (1), Pesqué et al28 …”

mentioning

confidence: 99%

Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature

Battista¹,

Marasca²,

Genco³

et al. 2022

CCID

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The outbreak of coronavirus disease 2019 represented a new worldwide challenge, strongly impacting on the global economy, overall health and lifestyle. Since then, several strategies have been adopted to contain the widespread of infection. Among these, vaccination is currently the most important measure to fight against the pandemic. However, several concerns such as slower-than-hoped-for rollout, the hurried approval with limited data, the mechanism of action (in particular mRNA-based), and the uncertain duration of protection they afforded were initially raised. Moreover, even if cutaneous reactions have been rarely reported in clinical trials, global mass vaccination showed several dermatologic reactions not initially recognized, leaving dermatologists to decide how to diagnose and treat them. In this scenario, dermatologists should be ready to promptly recognize these clinical manifestations. Thus, the aim of this manuscript is to review current literature on cutaneous reactions following COVID-19 vaccination, particularly inflammatory dermatological diseases, in order to help clinicians to better understand these dermatological conditions and to provide an extensive overview of all the vaccine-related skin manifestations.

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De novo annular pustular psoriasis following mRNA COVID‐19 vaccine

Cited by 9 publications

References 10 publications

Safety and Efficacy of Covid-19 Vaccination in Patients Undergoing Biological Treatments for Psoriasis

Safety and Efficacy of Covid-19 Vaccination in Patients Undergoing Biological Treatments for Psoriasis

Authors' reply to: ‘Generalized pustular figurate erythema first report in two COVID‐19 patients on hydroxychloroquine’

Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature

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