<i>Datura Stramonium</i>Intake: A Report on Three Cases

Stella, L.; Vitelli, Maria Redenta; Palazzo, Enza; Oliva, Patrizia; Novellis, Vito de; Capuano, Annalisa; Scafuro, Marika; Berrino, Liberato; Rossi, Francesco; Maione, Sabatino

doi:10.1080/02791072.2010.10400713

Cited by 14 publications

(9 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Recently, orally and smoked recreationally abuse/misuse of Datura leaves or flowers or the seeds has been reported by youngsters in search of strong sensations and to experience their hallucinogenic effects [ 59 ]. Among the most commonly reported desired effects, euphoria, surreal interactions with world and auditory hallucinations have been frequently reported by recreational users.…”

Section: Resultsmentioning

confidence: 99%

“…Several cases of toxicity following voluntary and recreationally ingestion of Datura extract were reported, particularly among children and teenagers [ 59 , 61 , 62 ]. The main clinical effects include anticholinergic delirium, restlessness, altered sensorium disorientation and a wide range of hallucinations (colloquially defined as Toxidrome: “Blind as a bat, mad as a hatter, red as a beet, hot as a hare, dry as a bone, the bowel and bladder lose their tone, and the heart runs alone”) [ 54 , 62 ].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Herbal Highs: Review on Psychoactive Effects and Neuropharmacology

Graziano

Orsolini

Rotolo

et al. 2017

View full text Add to dashboard Cite

Background: A new trend among users of new psychoactive substances’ the consumption of “herbal highs”: plant parts containing psychoactive substances. Most of the substances extracted from herbs, in old centuries were at the centre of religious ceremonies of ancient civilizations. Currently, these herbal products are mainly sold by internet web sites and easily obtained since some of them have no legal restriction.Objective: We reviewed psychoactive effects and neuropharmacology of the most used “herbal highs” with characterized active principles, with studies reporting mechanisms of action, pharmacological and subjective effects, eventual secondary effects including intoxications and/or fatalitiesMethod: The PubMed database was searched using the following key.words: herbal highs, Argyreia nervosa, Ipomoea violacea and Rivea corymbosa; Catha edulis; Datura stramonium; Piper methysticum; Mitragyna speciosa.Results: Psychoactive plants here reviewed have been known and used from ancient times, even if for some of them limited information still exist regarding subjective and neuropharmacological effects and consequent eventual toxicity when plants are used alone or in combination with “classical” drugs of abuse.Conclusion: Some “herbal highs” should be classified as harmful drugs since chronic administration has been linked with addiction and cognitive impairment; for some others taking into consideration only the recent trends of abuse, studies investigating these aspects are lacking.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Herbal Highs: Review on Psychoactive Effects and Neuropharmacology

Graziano

Orsolini

Rotolo

et al. 2017

View full text Add to dashboard Cite

show abstract

“…In each plant all parts contain alkaloids, but they are greatest in ripe seeds [4,7]. Central effects of alkaloids are usually psychotic-like signs and symptoms including delirium, hallucination, confusion, disorientation, agitation, aggression, photophobia, blurred vision, seizure and even coma [3,4,7,9]. Peripheral signs of alkaloids are mydriasis, dry skin and mouth, flushing, tachycardia, fever, hyper or hypotension and urinary retention [4,9,10].…”

Section: Discussionmentioning

confidence: 99%

“…The abuse of some of these herbals are welcomed by consumers because of their availability, low prices, lack of regulatory legislation and the commonly accepted idea of their higher safety compared to man-made or chemical preparations [2]. "Datura stramonium" species -also called "Jimson Weed" or "Angel's trumpet" -comprises of plants that are being abused as herbal psychoactive substances, usually by adolescents or youth [3]. Datura plants contain belladonna alkaloids (like Atropine, Scopolamine and Hyoscyamine), which cause central and peripheral anticholinergic effects [4][5][6].…”

mentioning

confidence: 99%

Datura poisoning, clinical and laboratory findings. Report of five cases

Arefi¹,

Barzegari²,

Asgari³

et al. 2016

RJLM

View full text Add to dashboard Cite

Introduction. Plants of Datura species contain belladonna alkaloids that can cause central and peripheral anticholinergic effects. Abuse of Datura plants for their hallucinogenic effects is growing among adolescents and young adults. Datura poisoning has caused a diagnostic challenge in medical emergency wards. In this article we report 5 cases of Datura toxicity at Clinical Toxicology Emergency of Baharloo Hospital, Tehran, Iran during Summer-Fall 2015, and discuss their clinical presentations and laboratory findings. Cases. All 5 cases with Datura toxicity were young males and had intentionally used the plants. Mean duration of hospitalization was 3.2 days. Three cases were multiple-drug abusers. Mydriasis, tachycardia, tachypnea and flushing alongside with psychotic-like signs and symptoms were observed in all cases. Elevation of liver enzymes was present in three of cases but without clinical significance. Raised LDH or CPK in four patients were without myoglobinuria and evidence of rhabdomyolysis and these biomarkers returned to normal levels by supportive care. All patients discharged with complete recovery and there was no need to ICU admission. Discussion. With the absence of routine laboratory diagnostic tests for alkaloids and complex and confusing presentations of Datura intoxication, diagnosis of such cases is difficult. Physicians' clinical suspicion and sufficient knowledge play the mainstay roles in appropriate and timely diagnosis and management of cases with Datura toxicity. Since regulatory legislation wouldn't be successful in halting the availability of natural plants, the best strategy to prevent Datura abuse is informing people about the adverse effects of these plants.

show abstract

“…207 Jimson weed has also been used as a drug of abuse, because of its hallucinogenic properties. 208,209 Other plants that can cause anticholinergic poisoning include angel's trumpet (Brugmansia spp., now called Datura), 210 found in Central and South America and prepared as a tea for its hallucinogenic effects and jessamine (Gelsemium semper virens; Figure 76.28), 211 which is native to North and Central America.…”

Section: Anticholinergic Compoundsmentioning

confidence: 99%

Plant Poisons and Traditional Medicines

Aronson¹

2014

Manson's Tropical Infectious Diseases

View full text Add to dashboard Cite

Datura StramoniumIntake: A Report on Three Cases

Cited by 14 publications

References 14 publications

Herbal Highs: Review on Psychoactive Effects and Neuropharmacology

Herbal Highs: Review on Psychoactive Effects and Neuropharmacology

Datura poisoning, clinical and laboratory findings. Report of five cases

Plant Poisons and Traditional Medicines

Contact Info

Product

Resources

About