<i>Dan</i> is required for normal morphogenesis and patterning in the developing chick inner ear

Yamanishi, Takahiro; Katsu, Kenjiro; Funahashi, Jun; Yumoto, Eiji; Yokouchi, Yuji

doi:10.1111/j.1440-169x.2007.00900.x

Cited by 10 publications

(12 citation statements)

References 54 publications

(133 reference statements)

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“…6a) which is supposed to bind BMP ligands . Vertebrate DAN was identified as an antitumorigenic factor (Enomoto et al 1994) and plays, among other functions, a role in ear development (Gerlach-Bank et al 2004;Yamanishi et al 2007). A DAN ortholog is found in the Apis genome as well (Fig.…”

Section: Modulators Of Tgfb Signalingmentioning

confidence: 96%

TGFβ signaling in Tribolium: vertebrate-like components in a beetle

2008

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The cytokines of the TGFbeta superfamily are highly conserved in evolution and elicit a diverse range of cellular responses in all metazoa. In Drosophila, the signaling pathways of the two TGFbeta subfamilies, Activins and Bone Morphogenetic Proteins (BMPs), have been well studied. To address the question of whether the findings from Drosophila are representative of insects in general, we analyzed the components of TGFbeta-signaling present in the genome of the beetle Tribolium castaneum. We were able to identify orthologs of the BMPs Decapentaplegic and Glass bottom boat, of the Activins Activinbeta and Dawdle, as well as orthologs of the less well-known ligands Myoglianin and Maverick, together with orthologs of all TGFbeta receptors and cytoplasmic signal transducers present in Drosophila. This indicates that the diversity of TGFbeta signaling components is generally well conserved between Drosophila and Tribolium. However, the genome of the beetle-and of the bee Apis mellifera-lacks an ortholog of the Drosophila BMP Screw but does contain a vertebrate-like BMP10 homolog which is not found in Drosophila. Concerning BMP inhibitors, Tribolium displays an even more vertebrate-like ensemble of components. We found two orthologs of the vertebrate DAN family, Dan and Gremlin, and show embryonic expression of a vertebrate-like BAMBI ortholog, all of which are absent in Drosophila. This suggests that Tribolium might have retained a more ancestral composition of TGFbeta signaling components and that TGFbeta signaling underwent considerable change in the Drosophila lineage. Tribolium is an excellent model to study the function of these ancestral signaling components in insects.

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Section: Modulators Of Tgfb Signalingmentioning

confidence: 96%

TGFβ signaling in Tribolium: vertebrate-like components in a beetle

2008

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“…The endogenous BMP antagonist, Dan, is expressed in the dorso-medial region of the otic placode at stages 13-24 (Yamanishi et al 2007). Increasing BMP activity either through the electroporation of siRNA against Dan or a constitutively active (ca) Alk6 receptor (BMP receptor 1b) resulted in ectopic upregulation of Msx1and Nkx5.1 in the neurogenic region of the otic vesicle (Yamanishi et al 2007). Taken together, Notch and FGF signals promote the neurogenic otic domain, whereas BMP activity is required for the non-neurogenic region to form.…”

Section: The Otic Placodementioning

confidence: 99%

Development of cranial placodes: Insights from studies in chick

Jidigam

Gunhaga

2012

Dev Growth Differ

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This review focuses on how research, using chick as a model system, has contributed to our knowledge regarding the development of cranial placodes. This review highlights when and how molecular signaling events regulate early specification of placodal progenitor cells, as well as the development of individual placodes including morphological movements. In addition, we briefly describe various techniques used in chick that are important for studies in cell and developmental biology.Key words: border, chick, invagination, placodes, signaling. Chick as a model system to unravel the development of cranial placodesCranial placodes are transient thickenings of the embryonic head ectoderm at specific positions that can be detected during vertebrate development. Cranial placodes found in chick are the hypophyseal, olfactory, lens, trigeminal, otic and epibranchial ( Fig. 1). All of these placodes, except the hypophyseal, will contribute to sensory components of the peripheral nervous system (PNS), and are usually referred to as sensory placodes. The hypophyseal placode will eventually form the endocrine part of the pituitary. Among the sensory placodes, the lens is the only placode that will not give rise to any neuronal derivatives. The individual placodes will give rise to specific cell types, and together the placodes form a variety of cell types including sensory receptor cells, neurons, endocrine cells and supporting cells.Cranial placodes derive from the neural plate border (border), a region of the embryonic ectoderm located between the prospective neural and the prospective epidermal domains. Recent studies have shown when and how extracellular signals result in the specification of border cells and the individual specification of various placodes. Although specification of placodal progenitors appears to be partly regulated by common molecular mechanisms, the development and patterning of individual cranial placodes are controlled by unique molecular codes. A key question during development of any tissue or organ is how a cell adopts one fate over another. Equally important is to understand how morphological movements occur, forming tissues and organs in specific shapes. The development of placodes includes both of these developmental processes, and these events must be strictly coordinated to form functional mature structures. To analyze the acquisition of cell identity and morphological movements, various molecular and developmental biology techniques in chick can be used, which are briefly mentioned in Box 1. This review, which focus on results from chick, can be used as a complement to existing reviews concerning placode development (Baker & Bronner-Fraser 2001;Streit 2004Streit , 2007Brugmann & Moody 2005;Schlosser 2006Schlosser , 2008Schlosser , 2010Ohyama et al. 2007;Sauka-Spengler & Bronner-Fraser 2008;McCabe & Bronner-Fraser 2009;Ladher et al. 2010;Gunhaga 2011;Patthey & Gunhaga 2011). In the following sections, we discuss recent progress concerning early development of cranial placodes using chick as ...

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“…Recently it has been reported that BMPs antagonist Dan is required for chick endolymphatic duct and sac (Gerlach et al . 2004; Yamanishi et al . 2007).…”

Section: Discussionmentioning

confidence: 99%

Role of Bone morphogenetic protein 4 in zebrafish semicircular canal development

et al. 2007

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Bone morphogenetic proteins (BMPs) are known to play roles in inner ear development of higher vertebrates. In zebrafish, there are several reports showing that members of the BMP family are expressed in the otic vesicle. We have isolated a novel zebrafish mutant gallery, which affects the development of the semicircular canal. Gallery merely forms the lateral and the immature anterior protrusion, and does not form posterior and ventral protrusions. We found that the expression of bmp2b and bmp4, both expressed in the normal optic vesicle at the protrusion stage, are extremely upregulated in the otic vesicle of gallery. To elucidate the role of BMPs in the development of the inner ear of zebrafish, we have applied excess BMP to the wild-type otic vesicle. The formation of protrusions was severely affected, and in some cases, they were completely lost in BMP4-treated embryos. Furthermore, the protrusions in gallery treated with Noggin were partially rescued. These data indicate that BMP4 plays an important role in the development of protrusions to form semicircular canals.

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Dan is required for normal morphogenesis and patterning in the developing chick inner ear

Cited by 10 publications

References 54 publications

TGFβ signaling in Tribolium: vertebrate-like components in a beetle

TGFβ signaling in Tribolium: vertebrate-like components in a beetle

Development of cranial placodes: Insights from studies in chick

Role of Bone morphogenetic protein 4 in zebrafish semicircular canal development

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