CYP1A1 MSPI (T6235C) gene polymorphism is associated with mortality in acute coronary syndrome patients

Abstract

1. The CYP1A1 T6235C polymorphism (rs4646903) gene polymorphism has been linked to the development of coronary heart disease and cigarette smoking-related lung cancer. The present study investigated associations between survival in acute coronary syndromes (ACS), smoking and the CYP1A1 T6235C polymorphism. 2. Patients with ACS (n = 1251) were genotyped for the CYP1A1 T6235C polymorphism. Patients had a mean age of 67.0 years, 69.8% were male and follow up occurred over a median of 1.9 years. 3. Overall genotype frequencies were CC 2.2%, TC 21.7% and TT 76.1%. The CC genotype was associated with baseline characteristics of a higher incidence of Type 2 diabetes (P = 0.017), elevated body mass index (P = 0.001) and younger age (P = 0.045). Patients with the CC genotype had significantly worse survival than TT/TC patients (P = 0.014), independent of ethnicity and established clinical risk factors. When survival was stratified by smoking history, the T6235C genotype was particularly associated with mortality in past or current smokers (mortality 23.5 vs 9.4% in CC and TT/TC patients, respectively; P = 0.019) compared with those who had never smoked (mortality 11.1 vs 11.5% in CC and TT/TC patients, respectively; P = 0.853). 4. The results indicate that the homozygous CYP1A1 6235C genotype is associated with greater mortality following the onset of ACS, independent of ethnicity and clinical risk factors, but related to smoking history.

Regulation of Human Cytochrome P4501A1 (hCYP1A1): A Plausible Target for Chemoprevention?

“…This attribute highlighted the importance of the association between heart diseases and CYP1A1 polymorphisms [138–140]. …”

KCNE5 Polymorphism rs697829 is Associated with QT Interval and Survival in Acute Coronary Syndromes Patients

“…3 Other studies have implicated other genetic variants as markers of the risk of development of ACS and clinical outcome during progression of the disease. [25][26][27] The frequency of rs697829 alleles in this cohort was similar to populations of European ancestry in the National Center for Biotechnology Information SNP database, http://www.ncbi.nlm.nih.gov/snp (dbSNP). Allele frequency was significantly associated with ethnicity, but this was largely due to differences between the predominant European group and the small Other and Unknown groups ( Table 2).…”

“…We have previously shown that a polymorphism in the X‐linked gene ACE2 was associated with covariate‐adjusted, but not unadjusted, survival in a cohort of male ACS patients 3 . Other studies have implicated other genetic variants as markers of the risk of development of ACS and clinical outcome during progression of the disease 25–27 …”

Lack of association between CYP1A1 T6235C polymorphism and coronary artery disease: Evidence from a meta-analysis

“…The search criteria identified 38 abstracts. Following elimination of studies that did not meet the criteria and exclusion of 19 records, 9 full-text publications were preliminarily identified for further evaluation (11)(12)(13)(14)(15)(16)(27)(28)(29). Each original manuscript was reviewed and data were extracted.…”