<i>Curcuma longa</i> and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review

Memarzia, Arghavan; Saadat, Saeideh; Behrouz, Sepideh; Boskabady, Mohammad Hossein

doi:10.1002/biof.1818

Cited by 15 publications

(8 citation statements)

References 137 publications

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“…Sesquiterpene lactones, cinnamic aldehyde and sesquiterpenes are the main molecules responsible for allergic reactions. 60 Extracts of Curcuma longa have shown respiratory, allergic and immunological disorders. 60 Photosensitisation: The cutaneous application of essential oils containing coumarins, especially furocoumarins or psoralens, can trigger erythematous reactions under sunlight exposure.…”

Section: Toxicity Of Plants Extracts and Their Bioactive Componentsmentioning

confidence: 99%

“…60 Extracts of Curcuma longa have shown respiratory, allergic and immunological disorders. 60 Photosensitisation: The cutaneous application of essential oils containing coumarins, especially furocoumarins or psoralens, can trigger erythematous reactions under sunlight exposure. The basic safety precaution is to avoid significant sun exposure for six hours after application.…”

Section: Toxicity Of Plants Extracts and Their Bioactive Componentsmentioning

confidence: 99%

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Pharmacological mechanisms of medicinal plant extracts in the treatment of dermatological diseases: in vitro, in vivo studies and clinical trials

KOMBATE¹,

Metowogo²

2023

JDC

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Dermatological diseases are common inflammatory affections of the skin. In recent times, interest in herbal medicine for the treatment of dermatological diseases has become more than necessary due to the side effects of conventional drugs and their ineffectiveness. To this end, the use of herbal medicine is a promising approach. The objective of this review is to list scientific articles and reviews on plant extracts or plant formulations used in the treatment of dermatological diseases including acne, psoriasis, dermatitis and wounds which are the most common affections. The following scientific databases were consulted: PubMed, Inari, science direct, Google scholar, Web of Science and Scopus. This review provides evidence that herbal medicines will be emerging and promising treatments for dermatological conditions. However, better quality evidence and standardized methodologies are needed to support and further investigate the efficacy, safety and security of these plants.

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Section: Toxicity Of Plants Extracts and Their Bioactive Componentsmentioning

confidence: 99%

Section: Toxicity Of Plants Extracts and Their Bioactive Componentsmentioning

confidence: 99%

Pharmacological mechanisms of medicinal plant extracts in the treatment of dermatological diseases: in vitro, in vivo studies and clinical trials

KOMBATE¹,

Metowogo²

2023

JDC

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“…100 The anti-inflammatory, antioxidant and immunomodulatory effects of CUR have also been reported in experimental lung disorders. 101 Some studies have looked at the potential anti-tumour mechanisms that C. longa and CUR adopt but further investigation is still needed to ascertain how they work.…”

Section: Curcuma Longamentioning

confidence: 99%

Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence

Memarzia,

Saadat,

Asgharzadeh

et al. 2023

J Cellular Molecular Medi

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The most common type of cancer in the world is lung cancer. Traditional treatments have an important role in cancer therapy. In the present review, the most recent findings on the effects of medicinal plants and their constituents or natural products (NP) in treating lung cancer are discussed. Empirical studies until the end of March 2022 were searched using the appropriate keywords through the databases PubMed, Science Direct and Scopus. The extracts and essential oils tested were all shown to effect lung cancer by several mechanisms including decreased tumour weight and volume, cell viability and modulation of cytokine. Some plant constituents increased expression of apoptotic proteins, the proportion of cells in the G2/M phase and subG0/G1 phase, and Cyt c levels. Also, natural products (NP) activate apoptotic pathways in lung cancer cell including p‐JNK, Akt/mTOR, PI3/ AKT\ and Bax, Bcl2, but suppressed AXL phosphorylation. Plant‐derived substances altered the cell morphology, reduced cell migration and metastasis, oxidative marker production, p‐eIF2α and GRP78, IgG, IgM levels and reduced leukocyte counts, LDH, GGT, 5′NT and carcinoembryonic antigen (CEA). Therefore, medicinal plant extracts and their constituents could have promising therapeutic value for lung cancer, especially if used in combination with ordinary anti‐cancer drugs.

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“…Curcuma longa has been used for anti-aging in Ayurvedic medicine for thousands of years. Curcumin, an antioxidant and anti-inflammatory substance, is found in the rhizomes of Curcuma longa ( Arshad et al, 2017 ; Shah et al, 2021 ; Memarzia et al, 2022 ; Salem et al, 2022 ). The compound also showed neuroprotective properties when it came to ethanol-induced brain damage.…”

Section: Role Of Natural Productsmentioning

confidence: 99%

Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance

Rahman

Wang²,

Islam³

et al. 2022

Front. Pharmacol.

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Natural substances originating from plants have long been used to treat neurodegenerative disorders (NDs). Parkinson’s disease (PD) is a ND. The deterioration and subsequent cognitive impairments of the midbrain nigral dopaminergic neurons distinguish by this characteristic. Various pathogenic mechanisms and critical components have been reported, despite the fact that the origin is unknown, such as protein aggregation, iron buildup, mitochondrial dysfunction, neuroinflammation and oxidative stress. Anti-Parkinson drugs like dopamine (DA) agonists, levodopa, carbidopa, monoamine oxidase type B inhibitors and anticholinergics are used to replace DA in the current treatment model. Surgery is advised in cases where drug therapy is ineffective. Unfortunately, the current conventional treatments for PD have a number of harmful side effects and are expensive. As a result, new therapeutic strategies that control the mechanisms that contribute to neuronal death and dysfunction must be addressed. Natural resources have long been a useful source of possible treatments. PD can be treated with a variety of natural therapies made from medicinal herbs, fruits, and vegetables. In addition to their well-known anti-oxidative and anti-inflammatory capabilities, these natural products also play inhibitory roles in iron buildup, protein misfolding, the maintenance of proteasomal breakdown, mitochondrial homeostasis, and other neuroprotective processes. The goal of this research is to systematically characterize the currently available medications for Parkinson’s and their therapeutic effects, which target diverse pathways. Overall, this analysis looks at the kinds of natural things that could be used in the future to treat PD in new ways or as supplements to existing treatments. We looked at the medicinal plants that can be used to treat PD. The use of natural remedies, especially those derived from plants, to treat PD has been on the rise. This article examines the fundamental characteristics of medicinal plants and the bioactive substances found in them that may be utilized to treat PD.

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Curcuma longa and curcumin affect respiratory and allergic disorders, experimental and clinical evidence: A comprehensive and updated review

Cited by 15 publications

References 137 publications

Pharmacological mechanisms of medicinal plant extracts in the treatment of dermatological diseases: in vitro, in vivo studies and clinical trials

Pharmacological mechanisms of medicinal plant extracts in the treatment of dermatological diseases: in vitro, in vivo studies and clinical trials

Therapeutic effects of medicinal plants and their constituents on lung cancer, in vitro, in vivo and clinical evidence

Multifunctional role of natural products for the treatment of Parkinson’s disease: At a glance

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