<i>Curculigo recurvata</i> W.T.Aiton exhibits anti‐nociceptive and anti‐diarrheal effects in Albino mice and an in silico model

Ahmad, Shabbir; Nasrin, Shamima; Reza, A. S. M. Ali; Chakrabarty, Nishan; Hoque, Md. Akramul; Islam, Sanjida; Kabir, Mohammad Shah Hafez; Tareq, Syed Mohammed; Alam, Ahm Khurshid; Haque, Md. Areeful; Arman, Mitra

doi:10.1002/ame2.12119

Cited by 11 publications

(8 citation statements)

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“…The formalin-induced paw licking test in Swiss albino mice was evaluated as previously described method [ 25 , 26 ]. All the animals were received with respective treatment 30 min before the commencement of the study as described in the experimental design section.…”

Section: Methodsmentioning

confidence: 99%

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Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

et al. 2021

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Merremia vitifolia (Burm.f.) Hallier f., an ethnomedicinally important plant, used in the tribal areas to treat various ailments including fever, headache, eye inflammation, rheumatism, dysentery, jaundice and urinary diseases. The present study explored the biological efficacy of the aqueous fraction of M. vitifolia leaves (AFMV) through in vitro and in vivo experimental models. The thrombolytic and anti-arthritic effects of AFMV were evaluated by using the clot lysis technique and inhibition of protein denaturation technique, respectively. The anti-nociceptive activity of AFMV was investigated in Swiss Albino mice by acetic acid-induced writhing test and formalin-induced paw licking test. The antioxidant activities of AFMV, including 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and total reducing power, were also tested. The qualitative phytochemical assays exhibited AFMV contains secondary metabolites such as alkaloid, carbohydrate, flavonoid, tannin, triterpenoids and phenols. In addition, AFMV showed strong antioxidant effects with the highest scavenging activity (IC50 146.61 µg/mL) and reducing power was increased with a dose-dependent manner. AFMV also revealed notable clot lysis effect and substantial anti-arthritic activity at higher doses (500 µg/mL) as compared with the control. The results demonstrated a promising reduction of the number of writhing and duration of paw licking in acetic acid-induced writhing test and formalin-induced paw licking test in a dose-dependent manner, respectively. In conclusion, AFMV provides the scientific basis of its folkloric usage, suggesting it as the vital source of dietary supplement.

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Section: Methodsmentioning

confidence: 99%

“…The acetic acid-induced writhing test in swiss albino mice was carried out as described with minor modification [25][26][27] . All the animals received respective doses 30 min before initiating the study as per the experimental design.…”

Section: Acetic Acid-induced Writhing Testmentioning

confidence: 99%

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

et al. 2021

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“…In the castor oil-induced diarrhea model, C. recurvate extract significantly prolonged the onset time of diarrhea, reduced the volume and weight of intestinal contents in mice, and significantly decreased gastrointestinal motility. Further in silico molecular docking analysis showed that curculigine and isocurculigine possessed the highest affinity for COX-1 and COX-2; isocurculigine was identified as the most effective anti-diarrheal compound [ 93 ].…”

Section: Pharmacological Propertiesmentioning

confidence: 99%

Phytochemistry and Pharmacological Activity of Plants of Genus Curculigo: An Updated Review Since 2013

Wang

2021

Molecules

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The genus Curculigo, as a folk herbal medicine, has been used for many years in China, treating impotence, limb limpness, and arthritis of the lumbar and knee joints. The last systematic review of the genus Curculigo was written in 2013, scientifically categorizing the phytochemistry and biological activities. Hitherto, the original compounds and their pharmacological activities were presented as the development of this genus, but there is not an updated review. To conclude the progression of the genus Curculigo, we collected the new literature published from 2013 to 2021 in PubMed, Web of Science, Google Scholar databases, and the Chinese National Knowledge Infrastructure. The novel chlorophenolic glucosides, curculigine, phenolic glycosides, orcinosides and polysaccharides were isolated from Curculigo. The new analyzing methods were established to control the quality of Curculigo as a herbal medicine. In addition, the pharmacological effects of Curculigo focused on anti-diabetes, antibacterial, anti-inflammatory, osteoporosis, antioxidation, etc. The antitumor and neuroprotective activities were newly explored in recent years. The application of herbal medicine was gradually developed in scientific methods. The medicinal value of the genus Curculigo needs to further investigate its pharmacological mechanisms. This new review offers more insights into the exploitation of the pharmacological value of the genus Curculigo.

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“…Protein preparation PDE4 (PDB ID:4WCU) [17], COX-1 (PDB ID: 2OYE) [7] and COX-2 (PDB ID:3HS5) [18] receptor were downloaded from the RCSB Protein Data Bank. Protein preparation wizard in Schrödinger Maestro was used for structure refinement of selected receptor proteins.…”

Section: Ligand Preparationmentioning

confidence: 99%

“…Since the acetic acid-induced writhing test does not distinguish between central or peripheral antinociceptive responses, we performed a formalin-induced paw licking test to evaluate neurogenic and inflammatory pain responses of MEXX [28]. This test showed biphasic nociceptive reactions such as an early phase (neurogenic phase) reaction and late phase (inflammatory phase) reaction [18]. Administration of formalin exhibited an acute nociceptive neurogenic pain due to direct triggers of nociceptive fibers (sensory C and A δ fibers) through the release of neuropeptides (substance P).…”

Section: Formalin-induced Paw Licking Feedbackmentioning

confidence: 99%

Xylia xylocarpa (Roxb.) Taub. Leaves Ameliorates Inflammation and Pain in Experimental Mice and Computer-Aided Model

Chowdhury

Chowdhur

Hasan

et al. 2021

Walailak J Sci & Tech

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Xylia xylocarpa (Roxb.) Taub. is traditionally used to treat several diseases, including leprosy, wound healing, gonorrhea, rheumatism, anemia, diarrhea and ulcer. This study evaluated the anti-inflammatory and anti-nociceptive activities of methanolic extract of Xylia xylocarpa leaves (MEXX) via in vitro, in vivo as well as in silico models. In vitro anti-inflammatory activity was determined by human red blood cell membrane stabilization study and protein denaturation while in vivo anti-nociceptive activity was examined by the acetic acid-induced writhing test (AAWT) and formalin-induced paw licking test (FIPLT). Additionally, trans-5-hydroxypipecolic acid was an identified compound of MEXX which was subjected to molecular docking analysis followed by ADME/T and toxicity analysis. Qualitative phytochemical screening revealed that MEXX was enriched with carbohydrates, flavonoids, alkaloids, proteins, tannins and showed significant total phenolic (1222.66 ± 0.66 mg GAE/g dried extract) and flavonoids contents (325.33 ± 1.76 mg QE/g dried extract) in quantitative phytochemical screening. Inflammatory studies unveiled that; MEXX significantly (p < 0.05) inhibited the hemolysis of membrane and protein at different concentrations (31.25 - 1000 μg/mL). The extract also displayed statistically significant analgesic responses in the acetic acid and formalin-induced test at several doses (200 and 400 mg/kg b.w). In AAWT, the extract exhibited 13.67 and 51.37 % inhibition of writhing at the doses 200 and 400 mg/kg body weight respectively. In formalin-induced paw licking test, the early phase pain inhibition was 54.64 % at the concentration of 400 mg/kg while during the latter phase at 400 mg/kg, the inhibition of pain was 43.82 %. According to molecular docking analysis, trans-5-hydroxypipecolic acid demonstrated a promising docking score against PDE4, COX-1, and COX-2 along with satisfied pharmacokinetic and toxicological properties. Finally, from the results it could be concluded that MEXX has potential anti-inflammatory and an-nociceptive effects that should require further investigation. HIGHLIGHTS Xylia xylocarpa minimizes the inflamation and pain Xylia xylocarpa showed significant analgesic activity Xylia xylocarpa revealed polyphenolic compounds including phenol, and flavonoid In in silico, trans-5-hydroxypipecolic acid possessed significant analgesic activity against COX-1 and COX-2 GRAPHICAL ABSTRACT

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Curculigo recurvata W.T.Aiton exhibits anti‐nociceptive and anti‐diarrheal effects in Albino mice and an in silico model

Cited by 11 publications

References 40 publications

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

Pharmacological insights into Merremia vitifolia (Burm.f.) Hallier f. leaf for its antioxidant, thrombolytic, anti-arthritic and anti-nociceptive potential

Phytochemistry and Pharmacological Activity of Plants of Genus Curculigo: An Updated Review Since 2013

Xylia xylocarpa (Roxb.) Taub. Leaves Ameliorates Inflammation and Pain in Experimental Mice and Computer-Aided Model

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