Cryptococcus neoformansosteomyelitis: Case report of two patients

Osteomyelitits Due to Cryptococcus neoformans in Advanced Age Case Report and Review of Literature

“…In cryptococcosis of the CNS, the form most frequently diagnosed, little attention is given to additional lesions, e. g. in the skeleton, which may be asymptomatic. In the pre-AIDS era the skeleton was involved in about 5 to 10 % of disseminated cryptococcosis cases (6,7,17,19). Up to 1974, according to Nottebart et al 37 cases with bone involvement had been reported ( 17).…”

“…In the pre-AIDS era the skeleton was involved in about 5 to 10 % of disseminated cryptococcosis cases (6,7,17,19). Up to 1974, according to Nottebart et al 37 cases with bone involvement had been reported ( 17). In making the differential diagnosis, Ewing sarcoma, osteogenic sarcoma, tuberculosis, coccidioidomycosis, North American blastomycosis, sporotrichosis, actinomycosis and Staphylococcus aureus infection are possibilities to be considered (8,34).…”

“…n. infection was not diagnosed until post mortem examination had revealed macroscopic lesions in the spine, rib and femur, shows that such skeletal involvement may remain clinically silent for a long period and consequently escape detection. It is usually a conspicuous X-ray finding that leads to the diagnosis of cryptococcosis of the bone (2,8,(15)(16)(17)(18)34). The bone lesions are usually described as predominantly lytic areas with a slight periosteal reaction.…”

“…any bone may be infected by Cr. n. ( 17). To be clinically useful, assessment of cryptococcosis of the bone as part of a disseminated infection requires histopathological, cultural and serological procedures (testing for antigen and antibodies in serum and CS F) (2,10,13,15,16,25,30).…”

Criptococosis vertebral. Comunicación de un caso y revisión bibliográfica

“…Los casos de criptococosis localizados fuera del SNC y de los pulmones son infrecuentes. La osteomielitis ocurre en 5-10% de los pacientes con enfermedad criptocóccica diseminada [2][3][4] . Las infecciones criptocóccicas esqueléticas aisladas ocurren con menos frecuencia aun, siendo la afección de la columna vertebral una de las más reportadas 1,2,[5][6][7] .…”