<i>Croton lobatus</i>, an African medicinal plant: Spectroscopic and chemical elucidation of its many constituents

Chabert, Philippe; Attioua, Barthélemy Koffi; Brouillard, Raymond

doi:10.1002/biof.5520270107

Cited by 6 publications

(3 citation statements)

References 11 publications

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“…In ancient times humans used various plants and herbs that grew in their environment to treat various illnesses. Medicinal plants have emerged as some of the most widely studied plants and significant interest has been shown in their chemistry because of their potential application in medicine [1][2][3] . Many of these medicinal plants contain chemical constituents that could cause harmful effects to human if taken in large quantities.…”

Section: Introductionmentioning

confidence: 99%

Chemical Analysis of Datura Metel Leaves and Investigation of the Acute Toxicity on Grasshoppers and Red Ants

Kuganathan

Ganeshalingam

2010

Journal of Chemistry

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The present study was carried out to analyse the inorganic and organic contents in the leaf ofDatura meteland to investigate the acute toxicity at varying concentrations on grasshoppers and red ants. We determined the calcium, magnesium and phosphorous in the ionic state quantitatively and carried out screening tests and solvent extraction using chloroform to find out the presence of organic groups such as alkaloids, flavanoids, saponins and steroids. The concentration of Ca2+, Mg2+, Fe3+and PO43-were found to be (4.28 ± 0.05)×104, (3.86 ± 0.009) ×104, (2.33 ± 0.007)×104and (4.65 ± 0.06)×104ppm respectively. The screening tests confirmed the presence of alkaloids and steroids and the absence of saponins and flavanoids. Increasing concentrations of the plant extracts (2500-15000 ppm) were added to grasshoppers (n = 10) and red ants (n = 10) in an experimental chamber. After 10 minutes of exposure, the numbers of live insects were counted. The results showed the EC50value was 12000 ppm for grasshoppers and 11600 ppm for red ants. Percentage mortality increased from 20-60% with increasing concentrations. Our results indicated that extract ofDatura metelleaves at higher concentrations was more toxic and it can be used as an insecticide against grasshoppers and red ants.

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Section: Introductionmentioning

confidence: 99%

Chemical Analysis of Datura Metel Leaves and Investigation of the Acute Toxicity on Grasshoppers and Red Ants

Kuganathan

Ganeshalingam

2010

Journal of Chemistry

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“…The percentage composition of the alkaloids, flavonoids, saponins, phenols and tannins in the leaves of C. lobatus water extract is presented in the Table II. This study revealed that C. lobatus contains carbohydrates, glycoside, saponins, steroids, triterpenes, flavonoids and tannins as contained in other species of Croton (Attioua, 2005;Burkill, 1985;Chabert et al, 2006;Farnsworth, 1969;Willaman and Li, 1970). Croton lobatus L. contained 5.22 % alkaloid that was classified into five different types by Barthelemy et al (2012).…”

Section: Phytochemical Studiesmentioning

confidence: 85%

In-vitro and in-vivo antibacterial effect of Croton lobatus Linnaeus L. on two days post surgical wounds in rats

Kilani¹,

Hassan²,

Fadason³

et al. 2019

Bangladesh J. Sci. Ind. Res.

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Phytochemical constituents of Croton lobatus L. (C. lobatus) water extracts and quantitative analysis were carried out following standard procedures. The antibacterial activity against Staphylococcus aureus (ATCC 33591); Streptococcus Spp; Pseudomonas aeruginosa (ATCC 9028); Proteus vulgaris; Escherichia coli (ATCC 43895); and Salmonella Spp (ATCC 4932) was carried out at the concentration of 0.5g/mL, 0.05 g/mL and 0.00 5g/mL of water. In vivo antimicrobial assay was carried out by creating four wounds of 0.5 by 0.5 cm on dorsal surface of a male albino rat under anesthesia. The wounds were left for 48 hrs, after which they were accessed and samples were collected for culture, identification and colony forming unit counts (CFU). Respective treatment using dried C. lobatus, C. lobatus (water extract), Physiological saline solution and Cicatrin powder was carried out and samples were collected at day one, three, five and seven after initiation of treatments for CFU counts on nutrient and MacConkey agar. The phytochemical studies revealed that C. lobatus contains carbohydrates, glycoside, saponins, steroids, triterpenes, flavonoids, alkaloids and tannins. Croton lobatus L. showed a dose dependent activity against micro organisms with C. lobatus 0.5 inhibited the growth of most bacteria at the zone of inhibition ≤ 21mm. This was also supported by in vivo antimicrobial assay. Secondary metabolite tannins, triterpenoids, flavonoids, crotonic acids and saponin were responsible for its antimicrobial activity against the tested microorganisms thereby supporting its usage by the traditional medicine practitioner in Nigeria to treat chronic wounds. Bangladesh J. Sci. Ind. Res.54(2), 139-146, 2019

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“…Chabert et al [35] isolated geranylgeraniol, betulinic acid, cholestan-3-one, 9,12,15octadecatrienoic acid methyl ester, 3-(4-methoxy phenyl)-2-phenyl acrylic acid, tetramethyl tetraentetracosanoic acid, octadecadienoic acid, tetramethyl-hexadeca tetraenyl ester, lobaceride, cholestan-5,7-dien-3-ol, ergosterol, 3-hydroxycholes-5-en-7-one, N-(2-hydroxy-1-phenylpropyl) benzamide from leaves and stems of A. lobata (Table 3) (Table 3). Attioua et al [10] isolated palmitanoide, onosmin B, onosmin A, N-(2-hydroxy-1-phenylpropyl) benzamide and aurentiamide acetate from aerial parts of A. lobata (Table 3).…”

Section: Chemical Composition Of Astraea Lobatamentioning

confidence: 99%

<i>Astraea lobata</i> (L) Klotzsch (Euphorbiaceae): An ethnopharmacological review

Maroyi¹

2018

Trop. J. Pharm Res

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Croton lobatus, an African medicinal plant: Spectroscopic and chemical elucidation of its many constituents

Cited by 6 publications

References 11 publications

Chemical Analysis of Datura Metel Leaves and Investigation of the Acute Toxicity on Grasshoppers and Red Ants

Chemical Analysis of Datura Metel Leaves and Investigation of the Acute Toxicity on Grasshoppers and Red Ants

In-vitro and in-vivo antibacterial effect of Croton lobatus Linnaeus L. on two days post surgical wounds in rats

<i>Astraea lobata</i> (L) Klotzsch (Euphorbiaceae): An ethnopharmacological review

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