<i>Crataegus songarica</i>methanolic extract accelerates enzymatic status in kidney and heart tissue damage in albino rats and its<i>in vitro</i>cytotoxic activity

Ganie, Showkat Ahmad; Dar, Tanveer Ali; Zargar, Sabuhi; Bhat, Aashiq Hussain; Dar, Khalid Bashir; Akbar, Muhammad; Zargar, Mohammad Afzal

doi:10.3109/13880209.2015.1066398

Cited by 11 publications

(11 citation statements)

References 39 publications

(33 reference statements)

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“…C. oxyacantha alcoholic extract produced an antiarrhythmic effect that was induced by digoxin in Wistar rats; however, in the clinical use of this extract, the hypotensive effect should be considered (Alp et al, 2015). Another in vivo study reported that administration of methanolic C. songarica extract at the dose of 300 mg/kg body weight to albino rats with CCl 4 -iduced toxicity significantly decreased serum creatinine, urea, and cholesterol, malondialdehyde (MDA) in kidney and heart tissues, along with recovery in antioxidant enzyme levels (Ganie et al, 2016). It was also reported that standardized Crataegus extract prevented DOCA-salt-induced hypertension and alteration of cardiac, vascular and renal structure and function in rats (Schini-Kerth et al, 2015).…”

Section: Venskutonismentioning

confidence: 99%

“…Ethanolic extract of C. microphylla flowers and leaf buds demonstrated cytotoxic and antiproliferative activity against HeLa cell (IC 50 = 0.871 mg/mL) and least cytotoxicity on normal human peripheral mononuclear cells (Bura et al, 2016). Methanol, ethanol and ethyl acetate extracts of C. songarica K. Koch exhib-ited potent in vitro anticancer activity on MCF-7, HeLa, HepG2, SF-295, SW480 and IMR-32 cancer cell lines with IC 50 values of 28.57-85.106 μg/mL, while methanol extract demonstrated protective activity for albino rats' kidney and heart tissue against CCl 4induced toxicity in vivo (Ganie et al, 2016). C. monogyna extract at 100-75 μg/mL concentrations exhibited better antiproliferative activity against C6 cell lines than 5-flurouracil drug (5-FU) and cisplatin, and also demonstrated considerable antiproliferative activity against HeLa cells (Yaglioglu et al, 2016).…”

Section: Venskutonismentioning

confidence: 99%

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Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Venskutonis¹

2018

JFB

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Hawthorn (Crataegus spp.) is one of the most famous plants which has been used as natural medicine and nutraceutical. Its phytochemical composition, bioactive compounds and health benefits have been intensively studied and hawthorn preparations may be recognized as classical natural products for cardiovascular health. Polyphenolic compounds of different hawthorn anatomical parts as well as their extracts have been the focus of a majority of these studies, although various other classes of natural health promoting constituents have also been isolated, identified and characterized. Regardless, numerous published reports have particularly focused on the activity mechanisms which are very important for supporting various health benefits. This review summarizes the most recent studies on hawthorn, mainly published since 2015. Search of different databases indicates that approximately 200 publications, which are relevant to phytochemistry and health benefits of Crataegus spp., have appeared since then, most of them have not been included in the existing reviews.

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Section: Venskutonismentioning

confidence: 99%

Section: Venskutonismentioning

confidence: 99%

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Venskutonis¹

2018

JFB

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“…The suppression of GSH, GR, GPx, and GST enzyme activity was also detected in both the kidney and heart tissue. In addition, CSME showed protective effect against CCl 4 -induced DNA damage of kidney and heart tissue [117].…”

Section: Detoxification Processes Via Plant Natural Substancesmentioning

confidence: 89%

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

et al. 2020

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Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.

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“…The % inhibition values of HCT116 (colorectal cancer) by Crataegus L. polysaccharide extract were reported as in a range from 20% to 80% between 125 and 1000 µg/mL concentrations (39). Ganie et al revealed that C. songarica methanol, ethanol and ethyl acetate extracts inhibited ~ 80%, 85%, 75% of SW480 (colorectal cancer) at 80 µg/mL concentration (40).…”

Section: Discussionmentioning

confidence: 99%

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

Deveci¹,

Cayan²,

Karakurt³

et al. 2020

Eur J Biol

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The aim of this study was to investigate antioxidant, enzyme inhibitory and cytotoxic activities of Agropyron repens and Crataegus monogyna methanol extracts with total phenolic and flavonoid contents.Materials and Methods: Total phenolic and flavonoid contents of A. repens and C. monogyna methanol extracts were measured according to Folin Ciocalteu and aluminum nitrate methods, respectively. Antioxidant and enzyme inhibitory activities of the methanol extracts were tested spectrophotometrically. Also, cytotoxic activities of the methanol extracts against DLD-1 and CCD-18Co were investigated by using Alamar Blue assay.Results: C. monogyna methanol extract with the highest total phenolic and flavonoid contents (68.13±0.34 µg GAEs/mg extract and 36.91±0.17 µg QEs/mg extract, respectively) had the best antioxidant activity in β-carotene-linoleic acid (IC 50 : 32.72±0.15 µg/mL), CUPRAC (A 0.50 : 282.69±0.25 µg/mL), DPPH • (IC 50 : 71.69±0.85 µg/mL), and ABTS •+ (IC 50 : 40.43±0.55 µg/ mL) assays. A. repens methanol extract showed the highest effect against AChE (18.73±0.47 %), BChE (37.59±1.07 %), urease (89.18±0.84%), α-glucosidase (6.71±0.23 %), whereas C. monogyna methanol extract showed the highest effect against tyrosinase (30.52±1.00%) and α-amylase (37.24±0.06 %). Also, A. repens (IC 50 : 57.38 µg/mL) and C. monogyna (IC 50 : 54.04 µg/ mL) methanol extracts showed close cytotoxic activity on DLD-1. Conclusion:Antioxidant, cytotoxic, and enzyme inhibitory activities of A. repens and C. monogyna methanol extracts were investigated with total phenolic and flavonoid contents in this study. The results obtained with this study strengthen the potential of the studied plants as a new source for the discovery of antioxidant, cytotoxic, and enzyme inhibitor agents.

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Crataegus songaricamethanolic extract accelerates enzymatic status in kidney and heart tissue damage in albino rats and itsin vitrocytotoxic activity

Abstract: Crataegus songarica methanol extract has a potential antioxidant effect as it protects the kidney and heart tissue against CCl4-induced toxicity, prevents DNA damage and showed strong anticancer activity.

Cited by 11 publications

References 39 publications

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Phytochemical composition and bioactivities of hawthorn (Crataegus spp.): review of recent research advances

Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

Antioxidant, Cytotoxic, and Enzyme Inhibitory Activities of Agropyron repens and Crataegus monogyna Species

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