<i>Cordyceps cicadae</i> Prevents Renal Tubular Epithelial Cell Apoptosis by Regulating the SIRT1/p53 Pathway in Hypertensive Renal Injury

Huang, Yi; Wang, Xu; Feng, Zhendong; Cui, Hailan; Zhu, Zebing; Xia, Chenhui; Han, Xueting; Liu, Wei Jing; Liu, Yu Ning

doi:10.1155/2020/7202519

Cited by 19 publications

(27 citation statements)

References 38 publications

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“…The hybrid of fruiting body and insect has been used as traditional Chinese medicine for 1600 years. It possesses many medical effects similar to Hirsutella sinensis such as antioxidation [ 1 , 2 ], anti-inflammation [ 3 , 4 ], lowering blood sugar [ 5 ], and renal protection [ 6 , 7 ]. Zheng’s findings indicated that HEA, an active compound from C. cicadae , has a beneficial effect on UUO-induced tubulointerstitial fibrosis by suppressing inflammation and renal fibroblast activation.…”

Section: Introductionmentioning

confidence: 99%

Lowering the Intraocular Pressure in Rats and Rabbits by Cordyceps cicadae Extract and Its Active Compounds

Lee

Hsu

et al. 2022

Molecules

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Cordyceps cicadae (CC), an entomogenous fungus that has been reported to have therapeutic glaucoma, is a major cause of blindness worldwide and is characterized by progressive retinal ganglion cell (RGC) death, mostly due to elevated intraocular pressure (IOP). Here, an ethanolic extract of C. cicadae mycelium (CCME), a traditional medicinal mushroom, was studied for its potential in lowering IOP in rat and rabbit models. Data showed that CCME could significantly (60.5%) reduce the IOP induced by microbead occlusion after 56 days of oral administration. The apoptosis of retinal ganglion cells (RGCs) in rats decreased by 77.2%. CCME was also shown to lower the IOP of normal and dextrose-infusion-induced rabbits within 60 min after oral feeding. There were dose effects, and the effect was repeatable. The active ingredient, N6-(2-hydroxyethyl)-adenosine (HEA), was also shown to alleviate 29.6% IOP at 0.2 mg/kg body weight in this rabbit model. CCME was confirmed with only minor inhibition in the phosphorylated myosin light chain 2 (pMLC2) pathway.

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Section: Introductionmentioning

confidence: 99%

Lowering the Intraocular Pressure in Rats and Rabbits by Cordyceps cicadae Extract and Its Active Compounds

Lee

Hsu

et al. 2022

Molecules

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“…It has been utilized extensively in traditional Chinese medicine to treat chronic renal diseases, heart palpitations, infantile convulsions, and dizziness [17]. In vivo treatment with CC reduced urine albumin, albumin-to-creatinine ratio, and kidney injury molecule-1 (kim-1), alleviated interstitial fibrosis, and suppressed renal α-smooth muscle actin (α-SMA) expression [18]. CC polysaccharides (CCP) exhibit an inhibitory effect on the formation of malondialdehyde and increase the antioxidative enzymes' activities [16].…”

Section: Introductionmentioning

confidence: 99%

Potential Protection Effect of ER Homeostasis of N6-(2-Hydroxyethyl)adenosine Isolated from Cordyceps cicadae in Nonsteroidal Anti-Inflammatory Drug-Stimulated Human Proximal Tubular Cells

Chyau

Peng

et al. 2021

IJMS

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Nonsteroidal anti-inflammatory drugs (NSAIDs) belong to a class of universally and commonly used anti-inflammatory analgesics worldwide. A diversity of drawbacks of NSAIDs have been reported including cellular oxidative stress, which in turn triggers the accumulation of unfolded proteins, enhancing endoplasmic reticulum stress, and finally resulting in renal cell damage. Cordyceps cicadae (CC) has been used as a traditional medicine for improving renal function via its anti-inflammatory effects. N6-(2-hydroxyethyl)adenosine (HEA), a physiologically active compound, has been reported from CC mycelia (CCM) with anti-inflammatory effects. We hypothesize that HEA could protect human proximal tubular cells (HK−2) from NSAID-mediated effects on differential gene expression at the mRNA and protein levels. To verify this, we first isolated HEA from CCM using Sephadex® LH−20 column chromatography. The MTT assay revealed HEA to be nontoxic up to 100 µM toward HK−2 cells. The HK−2 cells were pretreated with HEA (10–20 µM) and then insulted with the NSAIDs diclofenac (DCF, 200 µM) and meloxicam (MXC, 400 µM) for 24 h. HEA (20 µM) effectively prevented ER stress by attenuating ROS production (p < 0.001) and gene expression of ATF−6, PERK, IRE1α, CDCFHOP, IL1β, and NFκB within 24 h. Moreover, HEA reversed the increase of GRP78 and CHOP protein expression levels induced by DCF and MXC, and restored the ER homeostasis. These results demonstrated that HEA treatments effectively protect against DCF- and MXC-induced ER stress damage in human proximal tubular cells through regulation of the GRP78/ATF6/PERK/IRE1α/CHOP pathway.

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“…have been utilized as therapeutic agents for metabolic-related disorders ( Cao et al, 2020 ). Cordyceps cicadae has renoprotective effects on hypertensive renal injuries ( Huang et al, 2020 ). Entomopathogenic fungi have important biotechnological applications ( Hyde et al, 2019 ) and Paraisaria is no exception.…”

Section: Introductionmentioning

confidence: 99%

Three Novel Entomopathogenic Fungi From China and Thailand

Wei

Wanasinghe

Xu³

et al. 2021

Front. Microbiol.

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Entomopathogenic fungi are ubiquitous in tropical rainforests and feature a high level of diversity. This group of fungi not only has important ecological value but also medicinal value. Nevertheless, they are often ignored, and many unknown species have yet to be discovered and described. The present study aims to contribute to the taxonomical and phylogenetic understanding of the genus Paraisaria by describing three new species collected from Guizhou and Yunnan Provinces in China and Krabi Province in Thailand. The three novel species named Paraisaria alba, P. arcta, and P. rosea share similar morphologies as those in the genus Paraisaria, containing solitary, simple, fleshy stroma, completely immersed perithecia and cylindrical asci with thickened caps and filiform ascospores that often disarticulate at maturity. Phylogenetic analyses of combined LSU, SSU, TEF1-α, RPB1, RPB2, and ITS sequence data confirm their placement in the genus Paraisaria. In this study, the three entomopathogenic taxa are comprehensively described with color photographs and phylogenetic analyses. A synopsis table and a key to all treated species of Paraisaria are also included.

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Cordyceps cicadae Prevents Renal Tubular Epithelial Cell Apoptosis by Regulating the SIRT1/p53 Pathway in Hypertensive Renal Injury

Cited by 19 publications

References 38 publications

Lowering the Intraocular Pressure in Rats and Rabbits by Cordyceps cicadae Extract and Its Active Compounds

Lowering the Intraocular Pressure in Rats and Rabbits by Cordyceps cicadae Extract and Its Active Compounds

Potential Protection Effect of ER Homeostasis of N6-(2-Hydroxyethyl)adenosine Isolated from Cordyceps cicadae in Nonsteroidal Anti-Inflammatory Drug-Stimulated Human Proximal Tubular Cells

Three Novel Entomopathogenic Fungi From China and Thailand

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