Conidiobolus coronata granuloma of left inferior turbinate: a rare presentation

Abstract

Conidiobolus coronata of the inferior turbinate is rare. Such a fungal granuloma may be large enough to be confused with a benign or malignant lesion of the nasal cavity.

Case Report: Successful Management of Conidiobolus Lamprauges Rhinitis in a Dog

“…In limited human case reviews with nasal imaging available, Conidiobolus spp. infections resulted in either nasal mucosal thickening or granuloma formation without aggressive lysis of underlying bone (13)(14)(15). Findings in this dog were similar, the predominant change was the increased soft tissue within the affected nasal passageway lacking the lysis of the associated bony structures.…”

“…Successful medical intervention in humans with rhinofacial conidiobolomycosis have included the use of one or more of the following: itraconazole (13,14,(26)(27)(28)(29)(30), fluconazole (14), terbinafine (27,30), potassium iodide (27)(28)(29), and amphotericin B (29). There are limited reports in the veterinary literature that describe medical treatments for conidiobolomycosis.…”

“…The dog in this report demonstrated complete resolution of clinical disease after 75 days of systemic antifungal therapy and remained apparently healthy 231 days after discontinuation of therapy. The mean treatment length until complete resolution of clinical disease in humans with rhinofacial conidiobolomycosis is 6.3 months (range, 0.8-18.0 months) (11)(12)(13)(14)(24)(25)(26)(27)(28)(29)(30). In a previously reported dog with a Conidiobolus sp.…”

Conidiobolomycosis in relapsed acute lymphoblastic leukemia

“…There are several case reports of Conidiobolus infection from the Indian subcontinent 5–12. They have been reported mainly in adults and resulted in chronic subcutaneous infection and sinusitis.…”

Conidiobolomycosis in a Young Malaysian Woman Showing Chronic Localized Fibrosing Leukocytoclastic Vasculitis

“…9 In its earliest stages, this edema is reversible, but at some point it becomes irreversible-indurated, nonpitting edema. 2,33,63,64 Ostensibly, successful treatment of conidiobolomycosis has been reported for all forms of therapy used against this fungus: surgical excision of early inflammatory tumors 65 and antifungal Rx for more extensive disease (see Supplemental Digital Content Table 1, http://links.lww.com/AJDP/A5). An immune response that does not limit local fungal growth or cause excessive scarring leading to inadequate lymphatic clearance of fungal antigens can explain why a minority of patients develop facial elephantiasis.…”