Comamonas testosteroni meningitis in a patient with recurrent cholesteatoma

Abstract

Comamonas testosteroni, a lesser-known member of the genus, has shown little apparent capacity for causing infections in humans. We here present a case of purulent meningitis due to C. testosteroni, which occurred in a patient who had recurrent cholesteatoma. Ceftriaxone treatment was not effective in this patient even though in vitro the bacteria were susceptible to the drug. The patient responded well to meropenem therapy.

Unusual Pathogen<i> Comamonas testosterone </i>Sepsis<i> </i>Following Gastroenteritis<i> </i>in a 12 Months Old Child: Case Report and Literature Review

“…Most reported cases have immune suppression such as malignancy [13], on hemodialysis patients, [14] alcoholic patient, patient with hepatitis B infection with liver cirrhosis and hepatocellular carcinoma [15], and cholesteatoma [16]. Our patient was absolutely healthy and has no comorbid conditions, with no evidence of immunodeficiency.…”

“…Comamonas testosteroni initially has been considered as a nonpathogenic microorganism until 1987; after which year, it has being recognized as a human pathogen with spectrum of infections both in adult and children [4][5][6][7][8][9][10][11].…”

“…[1] Formerly known as Pseudomonas testosteroni. It is found in soil, plants, water saprophytes, and also may be found in humidifier reservoir water, even isolated from dromedary rumen fluid [2] It has became clinically important after 1987, when reports began accumulating on human infections such as cellulitis [4], peritonitis especially with a perforated appendix [5], bloodstream infection [6,7], infective endocarditis [8], purulent meningitis, [9] postoperative endophthalmitis [10] and hemodialysis catheter-related bacteremia [11]. However, cases of bloodstream infections caused by Comamonas testosteroni have been infrequently reported [12] and this is the first case reported in Oman in a 12 months old child.…”

Intra-Abdominal Infections Due to Comamonas kerstersii

“…In the literature, infections due to C. kerstersii may be underestimated because in previously published cases of Comamonas infection, identification of isolates has been achieved only by phenotypic methods, which do not allow differentiation among species of the genus (10)(11)(12)(13)(14)(15)(16).…”

Comamonas testosteroni: An Unusual Bacteria Associated with Acute Appendicitis

“…As in previously reported cases, our patient recovered uneventfully by force of surgical intervention and antibiotic therapy. Most of the reported C. testosteroni isolates are susceptible to aminoglycosides, fluoroquinolones, carbapenems, piperacillin-tazobactam, most cephalosporins, and trimethoprim-sulfamethoxazole (3,4,7).…”