<i>Citrus hystrix</i>
            leaf extract attenuated diabetic‐cataract in STZ‐rats

Umran, Nor Shahira Solehah; Mohamed, Suhaila; Lau, Seng Fong; Ishak, Nur Iliyani Mohd

doi:10.1111/jfbc.13258

Cited by 14 publications

(9 citation statements)

References 30 publications

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“…Further, it causes many age-related chronic diseases such as atherosclerosis, Alzheimer’s disease and cancer [ 107 , 108 , 109 , 110 , 111 ]. The antidiabetic and antioxidant activity of CH and its phytochemical constituents was described earlier in human adipocytes, cataract in streptozotocin-induced diabetic rats [ 112 ] and hepatoprotective effect in paracetamol-induced injury in rats [ 23 ]. However, the exact pathway of protective effect of CH on high glucose-induced neuronal senescence was not explored.…”

Section: Discussionmentioning

confidence: 99%

Citrus hystrix Extracts Protect Human Neuronal Cells against High Glucose-Induced Senescence

Pattarachotanant

Tencomnao

2020

Pharmaceuticals

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Citrus hystrix (CH) is a beneficial plant utilized in traditional folk medicine to relieve various health ailments. The antisenescent mechanisms of CH extracts were investigated using human neuroblastoma cells (SH-SY5Y). Phytochemical contents and antioxidant activities of CH extracts were analyzed using a gas chromatograph–mass spectrometer (GC-MS), 2,2-diphenyl-1-picryl-hydrazyl-hydrate (DPPH) assay and 2,2′-azino-bis (3-ethylbenzthiazoline-6-sulphonic acid) (ABTS) assay. Effects of CH extracts on high glucose-induced cytotoxicity, reactive oxygen species (ROS) generation, cell cycle arrest and cell cycle-associated proteins were assessed using a 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide tetrazolium (MTT) assay, non-fluorescent 2′, 7′-dichloro-dihydrofluorescein diacetate (H2DCFDA) assay, flow cytometer and Western blot. The extracts protected neuronal senescence by inhibiting ROS generation. CH extracts induced cell cycle progression by releasing senescent cells from the G1 phase arrest. As the Western blot confirmed, the mechanism involved in cell cycle progression was associated with the downregulation of cyclin D1, phospho-cell division cycle 2 (pcdc2) and phospho-Retinoblastoma (pRb) proteins. Furthermore, the Western blot showed that extracts increased Surtuin 1 (SIRT1) expression by increasing the phosphorylation of Glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Collectively, CH extracts could protect high glucose-induced human neuronal senescence by inducing cell cycle progression and up-regulation of SIRT1, thus leading to the improvement of the neuronal cell functions.

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Section: Discussionmentioning

confidence: 99%

Citrus hystrix Extracts Protect Human Neuronal Cells against High Glucose-Induced Senescence

Pattarachotanant

Tencomnao

2020

Pharmaceuticals

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“…To the best of our knowledge, only a study had investigated in vivo effects of C. hystrix extract. Drinking 150 or 300 mg/kg body weight of C. hystrix leaf extract in solution with water lowered fasting blood glucose in streptozotocin-induced diabetic rats [7]. The beneficial effects of the extract led to a significant reduction in the incidence of cataracts in the rats, a phenomenon which was believed to be associated with reductions in oxidative stress and inflammation, indicated by lower levels of malondialdehyde, prostaglandin E2, and tumor necrosis factor-α (TNF-α); attenuated vascular permeability was also observed due to decreased levels of vascular endothelial growth factor.…”

Section: Effects On Diabetesmentioning

confidence: 95%

“…The functional groups responsible for the glucose absorbency were most likely hydroxyl group and possibly methyl ester group of galacturonic acid detected in the C. hystrix extract [43]. [7] Fruit juice in combination with other extracts (functional drink)…”

Section: Effects On Diabetesmentioning

confidence: 99%

“…Animal studies have shown that plant extracts such as those of Parkia speciosa Hassk., which is rich in flavonoids, confer protective effects against hypertension [4], while Ganoderma lucidum proteoglycans protect against diabetes [5], and açaí seed extract rich in proanthocyanidins protects against dyslipidemia [6]. Citrus hystrix DC extract has shown protective effects against diabetes [7], hypertension [8], and dyslipidemia [9].…”

Section: Introductionmentioning

confidence: 99%

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Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders

2022

Self Cite

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Metabolic disorders like diabetes mellitus, hypertension, dyslipidemia, and obesity are major medical problems globally. The incidence of these disorders has increased tremendously in recent years. Studies have demonstrated that plants with antioxidant and anti-inflammatory properties have beneficial effects on these disorders. One of these plants is Citrus hystrix DC, commonly known as kaffir lime. This review aims to present updates on the progress of research regarding the use of C. hystrix in metabolic disorders. Phytochemical compounds, including β-pinene, sabinene, citronellal, and citronellol, have been detected in the plant; and its extract exhibited potential antidiabetic, antihyperlipidemic and anti-obesity activity, as well as prevention of development of hypertension. These beneficial properties may be attributable to the presence of bioactive compounds which have therapeutic potential in treating these metabolic disorders. The compounds have the potential to be developed as candidate drugs. This review will assist in validating the regulatory role of the extract and its bioactive compounds on metabolic disorders, thus expediting future research in the area.

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“…Recently, Laura et al reported that Hsd supplementation upregulated the expression of Na+/K+ ATPase in the heart tissue and exerted cardioprotective effects [24]. It has also been reported that oral treatment with Hsd ameliorated lens fluid influx and osmotic imbalance in diabetic cataract lenses [25]. Membrane insertion of TRPV4 and AQP5 was observed in response to accommodation changes [10,11].…”

Section: Discussionmentioning

confidence: 96%

Effect of Alpha-Glucosyl-Hesperidin Consumption on Lens Sclerosis and Presbyopia

Nakazawa

Doki

Sugiyama

et al. 2021

Cells

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Presbyopia is characterized by a decline in the ability to accommodate the lens. The most commonly accepted theory for the onset of presbyopia is an age-related increase in the stiffness of the lens. However, the cause of lens sclerosis remains unclear. With age, water microcirculation in the lens could change because of an increase in intracellular pressure. In the lens, the intracellular pressure is controlled by the Transient Receptor Potential Vanilloid (TRPV) 1 and TRPV4 feedback pathways. In this study, we tried to elucidate that administration of α-glucosyl-hesperidin (G-Hsd), previously reported to prevent nuclear cataract formation, affects lens elasticity and the distribution of TRPV channels and Aquaporin (AQP) channels to meet the requirement of intracellular pressure. As a result, the mouse control lens was significantly toughened compared to both the 1% and 2% G-Hsd mouse lens treatments. The anti-oxidant levels in the lens and plasma decreased with age; however, this decrease could be nullified with either 1% or 2% G-Hsd treatment in a concentration- and exposure time-dependent manner. Moreover, G-Hsd treatment affected the TRPV4 distribution, but not TRPV1, AQP0, and AQP5, in the peripheral area and could maintain intracellular pressure. These findings suggest that G-Hsd has great potential as a compound to prevent presbyopia and/or cataract formation.

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Citrus hystrix leaf extract attenuated diabetic‐cataract in STZ‐rats

Cited by 14 publications

References 30 publications

Citrus hystrix Extracts Protect Human Neuronal Cells against High Glucose-Induced Senescence

Citrus hystrix Extracts Protect Human Neuronal Cells against High Glucose-Induced Senescence

Potential Therapeutic Effects of Citrus hystrix DC and Its Bioactive Compounds on Metabolic Disorders

Effect of Alpha-Glucosyl-Hesperidin Consumption on Lens Sclerosis and Presbyopia

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