cis‐[Pt^II(1R,2R‐DACH)(3‐acetoxy‐1,1‐cyclobutanedicarboxylato)], a Water‐Soluble, Oxalate‐Free and Stable Analogue of Oxaliplatin: Synthesis, Characterization, and Biological Evaluations

Abstract

Strong, like ox! A new oxaliplatin derivative that features 3‐acetoxy‐1,1‐cyclobutanedicarboxylate as the leaving group has good aqueous solubility and stability. It exhibits higher antitumor activity and greater tolerability than oxaliplatin.

A Novel Pd Precursor Loaded γ‐Al2O3 with Excellent Adsorbent Performance for Ultra‐Deep Adsorptive Desulfurization of Benzene

“…In an aqueous solution, the complex dissociates into NH 4+ and the coordination anion [Pd(NO 2 ) 2 (C 2 O 4 )] 2− , which can be detected using electrospray ionization-mass spectroscopy (ESIMS) at m/e = 140 (Figure S3, Supporting Information). [25,26] The atomic weight of Pd corresponds to 104 2− ions that coordinate with Pd 2+ decompose, and the remaining Pd 2+ is anchored on the surface of alumina because of strong interactions with γ Al 2 O 3 to form PdOAl. Because the target complex has more and larger ligands than other precursors, the mutual repulsion between complexes makes Pd highly dispersed on the surface of Al 2 O 3 .…”

“…In an aqueous solution, the complex dissociates into NH 4+ and the coordination anion [Pd(NO 2 ) 2 (C 2 O 4 )] 2− , which can be detected using electrospray ionization–mass spectroscopy (ESI‐MS) at m/e = 140 (Figure S3, Supporting Information). [ 25,26 ] The atomic weight of Pd corresponds to 104 Pd, a naturally stable isotope. The results show that the synthesized Pd complex had the chemical structure of (NH 4 ) 2 [Pd(NO 2 ) 2 (C 2 O 4 )]·nH 2 O.…”