<i>Cimicifuga racemosa</i>treatment and health related quality of life in post-menopausal Spanish women

Mollá, Maria Dolores Juliá; Garcı́a-Sánchez, Yolanda; Sarrió, Alberto Romeu; Pérez‐López, Faustino R.

doi:10.1080/09513590802404005

Cited by 23 publications

(5 citation statements)

References 37 publications

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“…Another, uncontrolled study in 122 patients demonstrated a significant increase in the quality of life after 3 months of treatment [24]. …”

Section: Discussionmentioning

confidence: 99%

Differentiated Evaluation of Extract-Specific Evidence onCimicifuga racemosa's Efficacy and Safety for Climacteric Complaints

Neff

2013

Evidence-Based Complementary and Alternative Medicine

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Past reviews on Cimicifuga racemosa (CR) without differentiation between extracts, quality, and indication altogether led to inconsistent data. Therefore, for the first time, we meet the requirements of the system's logic of evidence-based phytotherapy by taking into consideration extracts, pharmaceutical quality (reflected in a regulatory status as medicinal product), and indication. A literature search for clinical studies examining CR's efficacy and safety for menopausal complaints was conducted. The results were sorted by type of extract, regulatory status, and indication. Accordingly, Oxford Levels of Evidence (LOE) and Grades of Recommendation (GR) were determined. CR extracts demonstrated a good to very good safety in general, on estrogen-sensitive organs and the liver. However, only registered CR medicinal products were able to prove their efficacy. Best evidence was provided by the isopropanolic CR extract (iCR): the multitude of studies including more than 11,000 patients demonstrated consistent confirmatory evidence of LOE 1b (LOE 1a for safety) leading to GR A. The studies on the ethanolic extract BNO 1055 including more than 500 patients showed exploratory evidence of LOE 2b resulting in GR B. A positive benefit-risk profile is stated and limited to Cimicifuga racemosa products holding a marketing authorisation for treating climacteric complaints.

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“…Another, uncontrolled study in 122 patients demonstrated a significant increase in the quality of life after 3 months of treatment [24]. …”

Section: Discussionmentioning

confidence: 99%

Differentiated Evaluation of Extract-Specific Evidence onCimicifuga racemosa's Efficacy and Safety for Climacteric Complaints

Neff

2013

Evidence-Based Complementary and Alternative Medicine

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“…Adverse events rates did not differ significantly between black cohosh and placebo ( Wuttke et al, 2003 ; Osmers et al, 2005 ). Significant and clinically relevant reductions in menopausal symptoms ( Vermes et al, 2005 ) or higher quality of life ( Julia Molla et al, 2009 ) were observed after treatment with black cohosh compared to therapy start. Sage taken for 8 weeks significantly decreased the number of menopausal hot flushes from week to week ( Bommer et al, 2011 ).…”

Section: Resultsmentioning

confidence: 99%

Current state of research on the clinical benefits of herbal medicines for non-life-threatening ailments

Salm,

Rutz,

van den Akker

et al. 2023

Front. Pharmacol.

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Herbal medicines are becoming increasingly popular among patients because they are well tolerated and do not exert severe side effects. Nevertheless, they receive little consideration in therapeutic settings. The present article reviews the current state of research on the clinical benefits of herbal medicines on five indication groups, psychosomatic disorders, gynecological complaints, gastrointestinal disorders, urinary and upper respiratory tract infections. The study search was based on the database PubMed and concentrated on herbal medicines legally approved in Europe. After applying defined inclusion and exclusion criteria, 141 articles were selected: 59 for psychosomatic disorders (100% randomized controlled trials; RCTs), 20 for gynecological complaints (56% RCTs), 19 for gastrointestinal disorders (68% RCTs), 16 for urinary tract infections (UTI, 63% RCTs) and 24 for upper respiratory tract infections (URTI) (79% RCTs). For the majority of the studies, therapeutic benefits were evaluated by patient reported outcome measures (PROs). For psychosomatic disorders, gynecological complaints and URTI more than 80% of the study outcomes were positive, whereas the clinical benefit of herbal medicines for the treatment of UTI and gastrointestinal disorders was lower with 55%. The critical appraisal of the articles shows that there is a lack of high-quality studies and, with regard to gastrointestinal disorders, the clinical benefits of herbal medicines as a stand-alone form of therapy are unclear. According to the current state of knowledge, scientific evidence has still to be improved to allow integration of herbal medicines into guidelines and standard treatment regimens for the indications reviewed here. In addition to clinical data, real world data and outcome measures can add significant value to pave the way for herbal medicines into future therapeutic applications.

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“…Other studies of perimenopausal women have reported a benefit of iCR on depressive symptoms, although these studies either used an active control (Huang et al, 2013; Nappi et al, 2005) or were uncontrolled observational studies with no placebo group (Arriaza Peso et al, 2008; Briese et al, 2007; Juliá Mollá et al, 2009). Therefore, it is difficult to draw any conclusions about the potential benefits of iCR, or other forms of black cohosh, for the treatment of depression during the menopausal transition.…”

Section: Symptoms Of the Menopausementioning

confidence: 99%

The role of diet in managing menopausal symptoms: A narrative review

et al. 2023

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Menopause is a natural stage that occurs when women stop menstruating, during which many women experience physical and psychological symptoms that can affect their quality of life and ability to work. Dietary modifications and food supplements may be explored by some women as alternatives to hormone replacement therapy, although existing reviews and expert position statements have given this limited consideration. This narrative review summarises the current evidence for dietary patterns, and botanical and food supplements, in the management of common menopausal symptoms, including vasomotor symptoms (VMS; hot flushes; night sweats), changes in bodyweight and composition, psychological symptoms (depression; anxiety; cognitive changes), sleep disturbances, joint pain, skin changes and urogenital symptoms. Soy isoflavones may reduce the frequency and/or severity of VMS, although results are inconsistent, and it is unclear whether dietary and supplemental sources have comparable effects. Adopting a healthier dietary pattern may support a healthy bodyweight and benefit VMS. However, evidence suggesting dietary patterns may benefit depression, anxiety, and cognition remains largely observational. While some botanicals, such as black cohosh and St John's Wort, have been reported in some studies to alleviate symptoms (such as VMS and depression), these are not currently recommended due to uncertainty about the appropriate dose and preparation, and potential safety concerns. Evidence for other symptoms is currently too limited to draw conclusions. While further trials at different menopausal stages are needed, adopting a healthier dietary pattern in accordance with dietary guidelines is likely to help support women's health before, during and after the menopausal transition.

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Cimicifuga racemosatreatment and health related quality of life in post-menopausal Spanish women

Abstract: CR treatment increased both global quality of life and the four domains of the Cervantes HR-QoL scale, being an effective treatment to reduce symptoms in post-menopausal woman with elevated body weight.

Cited by 23 publications

References 37 publications

Differentiated Evaluation of Extract-Specific Evidence onCimicifuga racemosa's Efficacy and Safety for Climacteric Complaints

Differentiated Evaluation of Extract-Specific Evidence onCimicifuga racemosa's Efficacy and Safety for Climacteric Complaints

Current state of research on the clinical benefits of herbal medicines for non-life-threatening ailments

The role of diet in managing menopausal symptoms: A narrative review

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