Chryseobacterium indologenespneumonia in a patient with non-Hodgkin's lymphoma

Abstract

SUMMARYA 42-year-old man diagnosed with gastric non-Hodgkin's lymphoma 2 years earlier, for which he had undergone treatment, presented with expectorative cough, exertional shortness of breath and left-sided chest pain of 3 months duration. Respiratory system examination was suggestive of left-sided pneumonia with pleural effusion. Routine haemogram showed leukocytosis with high erythrocyte sedimentation rate. Chest radiograph showed blunting of left-sided cardiophrenic angle. Sputum culture grew Chryseobacterium indologenes. Diagnostic thoracocentesis was suggestive of lymphomatous metastasis. Pleural fluid culture was sterile. Contrastenhanced CT (CECT) of the thorax showed left lower lobe consolidation with bilateral pleural effusion. The patient was treated with antibiotics, following which his cough improved and total leukocyte count normalised. Sputum culture repeated after the antibiotic course showed no growth of C. indologenes. However, the pleural effusion soon aggravated along with features suggestive of multiple metastasis. The patient finally succumbed to his underlying advanced malignancy. BACKGROUND

Chryseobacterium indologenes Ventilator-Associated Pneumonia in an Elderly Patient: A Case Report

“…Since the firstly reported infection in 1993 of ventilator-associated pneumonia caused by C. indologenes, an increasing number of infections have been described in recent years [2,3]. Among these cases, pneumonia, bacteremia, endocarditis, ocular infections, cellulitis, pleural, and peritoneal infections have been recognized [6,7,[9][10][11][12][13]. Infections of the urinary tract, biliary tract, lumboperitoneal shunt, burn wound, and surgical site have been also reported [7,14].…”

Challenges in the identification of Chryseobacterium indologenes and Elizabethkingia meningoseptica in cases of nosocomial infections and patients with cystic fibrosis

“…There are a total of 251 articles on C. indologenes in the National Center for Biotechnology Information database when the widest possible search criteria are used, including articles on bacterial resistance [6] , [7] , pneumonia [8] , [9] , paediatric infections [10] , [11] and CF [4] , [7] . The same occurs in the case of E. meningoseptica, for which the same database lists 1436 published articles concerning contamination of hospital water [12] , [13] , bacteraemia [14] , [15] , [16] and CF [4] , [17] .…”

Pleural effusion due to Chryseobacterium indologenes: Case report and review of literature

“…C. indologenes presents with a high rate of resistance against commonly used antibiotics such as aminoglycosides, chloramphenicol, penicillins, aztreonam, cephalosporins, [6] 2017 Turkey 69/male COPD Sputum Improved Soydan et al, Drug Discov Ther 2017 [7] 2017 Japan 64/female Adult T-cell leukemia/lymphoma Sputum Expired Imataki and Uemura Clin Case Rep 2017 [8] 2016 Spain NA NA NA NA Chiscano-Camón et al, Med Clin (Barc) 2016 [9] 2016 Spain 63/female Parietal oligodendroglioma postsurgery, chemotherapy, radiotherapy BAL Improved Peñasco et al, Med Intensiva 2016 [10] 2015 Turkey 82/male NA Transtracheal aspirate Improved Nemli et al, Case Rep Infect Dis 2015 [11] 2015 Tunisia NA NA NA NA Ben Salah et al, Rev Pneumol Clin 2015 [12] 2014 India 42/male Gastric non-Hodgkin's lymphoma Sputum Improved initially Shahul et al, BMJ Case Rep 2014 [13] 2013 USA 66/male Trauma BAL Improved Monteen et al, Ann Pharmacother 2013 [14] [16] 2007 France NA NA NA NA Reynaud et al, Med Mal Infect 2007 [17] COPD=Chronic obstructive pulmonary disease, BAL=Bronchoalveolar lavage, ET aspirate=Endotracheal aspirate, NA=Data not available and carbapenems. Since the C. indologenes isolate was multidrug resistant, our patient did not respond to the empirical antibiotic therapy.…”