<i>CHRNA3</i> rs1051730 and <i>CHRNA5</i> rs16969968 polymorphisms are associated with heavy smoking, lung cancer, and chronic obstructive pulmonary disease in a mexican population

Pérez‐Morales, Rebeca; González‐Zamora, Alberto; González-Delgado, María Fernanda; Rincón, Esperanza Yasmín Calleros; Calderón, Edgar Héctor Olivas; Martínez-Ramírez, Ollin Celeste; Rubio, Julieta

doi:10.1111/ahg.12264

Cited by 24 publications

(17 citation statements)

References 33 publications

(32 reference statements)

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“…Their results support the hypothesis that the T allele may have a protective effect. Importantly, they are in accordance with results from several other studies which show the association of CHRNA3 rs578776 with reduced risk for NA (Bierut et al, 2008) and a protective effect of this SNP against the risk of heavy smoking (Conlon and Bewick, 2011;Pérez-Morales et al, 2018). Another study of Hong and collaborators identified two CHRNA3 variants, namely the rs578776 and rs1051730 (Hong et al, 2010).…”

Section: Current State Of the Art Of The Associations Identified Between Chrna3 Variants Na And Brain Function In Humanssupporting

confidence: 90%

Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution

et al. 2020

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Section: Current State Of the Art Of The Associations Identified Between Chrna3 Variants Na And Brain Function In Humanssupporting

confidence: 90%

Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution

et al. 2020

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“…Furthermore, Table S1 again shows that a high expression level of α5‐nAChR and survivin is associated with poor prognosis in LUAD samples. Our results are consistent with those of previous studies that demonstrated that α5‐nAChR is likely to be a biomarker of lung carcinogenesis (Le Marchand et al, 2008; Perez‐Morales et al, 2018) and they provide additional evidence of the importance of α5‐nAChR activity in LUAD diagnosis.…”

Section: Discussionsupporting

confidence: 93%

“…Studies have shown that homomeric α7-nAchR is one of the main nAChR subtype mediating the proliferative and angiogenic effects of nicotine in lung cancer cells (Hajiasgharzadeh et al, 2019;Lyukmanova et al, 2018;Xu et al, 2019). It is worth noting that CHRNA5, encoding α5-nAchR, was highly associated with nicotine-related lung carcinogenesis confirmed by GWAS studies (Kuryatov, Berrettini, & Lindstrom, 2011;Perez-Morales et al, 2018). α5-nAChR has been implicated in nicotine addiction and in determining the number of cigarettes smoked (Sarginson et al, 2011).…”

Section: Discussionmentioning

confidence: 92%

α5‐nAChR and survivin: Two potential biological targets in lung adenocarcinoma

Zhang

Sun

Jia

et al. 2020

Journal Cellular Physiology

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Recent studies have shown that the overexpression of α5 nicotinic acetylcholine receptor (α5-nAChR) is associated with nicotine-related lung carcinogenesis. Survivin is one of the biomarkers of a worse prognosis for smoking-related lung cancer. The aim of this study is to investigate the association of α5-nAChR, survivin, and clinical outcomes in lung adenocarcinoma (LUAD). We analyzed the expression level and correlation of CHRNA5 (encoding α5-nAChR) and BIRC5 (encoding survivin) in LUAD with The Cancer Genome Atlas data set. The relationship between overall survival (OS) and the expression of CHRNA5 or/and BIRC5 was evaluated by the Kaplan-Meier method and Cox proportional hazards model. Moreover, our results showed that the expression of α5-nAChR mediated survivin expression in lung cancer cells and in lung tumor xenografts. Relationships between the expression of α5-nAChR and/or survivin with clinical-pathological characteristics were analyzed using LUAD tissue samples. The results showed that expression of α5-nAChR was correlated with survivin expression in vitro and in vivo. The group coexpressing α5-nAChR and survivin had a worse prognosis than other subgroups in LUAD (p < .05). In conclusion, ascertaining the expression of both α5-nAChR and survivin provides a better measure of prognosis for LUAD patients. The combined inhibition of α5-nAChR and survivin may be a promising multitargeted gene therapeutic strategy in LUAD diagnosis.

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“…In vitro studies indicate that rs16969968 decreases CHRNA5 function and favors nicotinic addiction [20]. Numerous studies have been performed to find out whether this association is direct, or whether the rs16969968 SNP is simply a proxy for increased exposure to tobacco carcinogens, which were inconclusive [7,[21][22][23][24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria

et al. 2020

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Lung cancer remains the most common cancer in the world. The genetic polymorphisms (rs2853669 in TERT, rs1052133 in OGG1, and rs16969968 in CHRNA5 genes) were shown to be strongly associated with the risk of lung cancer. Our study's aim is to elucidate whether these polymorphisms predispose Eastern Algerian population to non-small-cell lung cancer (NSCLC). To date, no study has considered this association in the Algerian population. This study included 211 healthy individuals and 144 NSCLC cases. Genotyping was performed using TaqMan probes and Sanger sequencing, and the data were analyzed using multivariate logistic regression adjusted for covariates. The minor allele frequencies (MAFs) of TERT rs2853669, CHRNA5 rs16969968, and OGG1 rs1052133 polymorphisms in controls were C: 20%, A: 31%, and G: 29%, respectively. Of the three polymorphisms, none shows a significant association, but stratified analysis rs16969968 showed that persons carrying the AA genotype are significantly associated with adenocarcinoma risk (pAdj = 0:03, ORAdj = 2:55).Smokers with an AA allele have a larger risk of lung cancer than smokers with GG or GA genotype (pAdj = 0:03, ORAdj = 3:91), which is not the case of nonsmokers. Our study suggests that CHRNA5 rs16969968 polymorphism is associated with a significant increase of lung adenocarcinoma risk and with a nicotinic addiction.

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CHRNA3 rs1051730 and CHRNA5 rs16969968 polymorphisms are associated with heavy smoking, lung cancer, and chronic obstructive pulmonary disease in a mexican population

Abstract: CHRNA3/5 polymorphisms are associated with nicotine dependence, LC, and COPD in Mexicans.

Cited by 24 publications

References 33 publications

Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution

Genetic susceptibility to nicotine addiction: Advances and shortcomings in our understanding of the CHRNA5/A3/B4 gene cluster contribution

α5‐nAChR and survivin: Two potential biological targets in lung adenocarcinoma

Association of TERT, OGG1, and CHRNA5 Polymorphisms and the Predisposition to Lung Cancer in Eastern Algeria

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