<i>Chlamydia trachomatis</i> seropositivity is associated both with stillbirth and preterm delivery

Gencay, Mesut; Koskiniemi, Marjaleena; Ämmälä, Pirkko; Fellman, Vineta; Närvänen, Ale; Wahlström, Torsten; Vaheri, Antti; Puolakkainen, Mirja

doi:10.1034/j.1600-0463.2000.d01-101.x

Cited by 56 publications

(40 citation statements)

References 28 publications

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“…Pregnant women could be a specific target group for C. trachomatis screening. Antenatal screening, as recommended by the Centers for Disease Control and Prevention (3), may be beneficial for decreasing morbidity among women themselves but also to prevent vertical (infant) and horizontal (partner) transmission (2,6,8,9,24). Screening of pregnant women usually yields prevalences similar to those obtained with nonpregnant women.…”

Section: Discussionmentioning

confidence: 92%

“…Asymptomatic carriers are of substantial importance in the transmission of C. trachomatis infection within a community. Asymptomatic chlamydial infection in pregnant women imposes an additional risk for acute and chronic consequences for the women themselves and their (unborn) offspring (2,6,8,9,16). In The Netherlands, C. trachomatis causes most sexually transmitted infections, with approximately 60,000 new cases estimated for a total population of 16 million in the year 2000.…”

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confidence: 99%

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Use of Pooled Urine Samples and Automated DNA Isolation To Achieve Improved Sensitivity and Cost-Effectiveness of Large-Scale Testing for Chlamydia trachomatis in Pregnant Women

et al. 2005

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The success of large-scale screening for Chlamydia trachomatis depends on the availability of noninvasive samples, low costs, and high-quality testing. To evaluate C. trachomatis testing with pregnant women, first-void urine specimens from 750 consecutive asymptomatic pregnant women from the Rotterdam area (The Netherlands) were collected. Initially, we investigated the performance of three different DNA isolation methods with 350 of these urines and 70 pools of 5 of the same subset of urine samples. The routinely used COBAS AMPLICOR test was compared to the COBAS AMPLICOR test with prior DNA isolation by use of the MagNA Pure large-volume kit and the MagNA Pure bacterial DNA isolation kit. The latter combination provided the best DNA test for pooled urines, with a sensitivity twice that of the other methods. Next, using all 750 urines, the COBAS AMPLICOR performance for individual testing was compared to pooled testing with the standard COBAS AMPLICOR procedure and subsequently to pooled testing with COBAS AMPLICOR in combination with the MagNA Pure bacterial DNA isolation kit. The sensitivity of COBAS AMPLICOR was 65% on individual and 42% on pooled urines but improved to 92% on pooled urines with the MagNA Pure bacterial DNA isolation kit, making this combination the best screening method. The C. trachomatis prevalence in this population appeared to be 6.4%. Additionally, the cost of the combined MagNA Pure bacterial DNA isolation kit and COBAS AMPLICOR method on pooled urines was only 56% of the cost of the standard COBAS AMPLICOR test applied to individual urines. Costs per positive case detected in the combined method were 39% of standard costs.Chlamydia trachomatis is one of the major sexually transmitted pathogens, and high prevalences of chlamydial infection have been documented for asymptomatic women in many European countries (34). Asymptomatic carriers are of substantial importance in the transmission of C. trachomatis infection within a community. Asymptomatic chlamydial infection in pregnant women imposes an additional risk for acute and chronic consequences for the women themselves and their (unborn) offspring (2,6,8,9,16). In The Netherlands, C. trachomatis causes most sexually transmitted infections, with approximately 60,000 new cases estimated for a total population of 16 million in the year 2000. Studies in general practice have shown an increase in the incidence of chlamydial infections (26), but data covering other specific target groups outside of the sexually transmitted disease (STD) outpatient clinics are sparse (1). Dutch population-based screening for C. trachomatis is still under debate, with cost-effectiveness of screening, complexity of sampling, the reliability of test methods, and the nature of the target population as major issues of discussion (23).In order to investigate the prevalence of chlamydial infection during pregnancy in Rotterdam, and the risk factors and consequences of chlamydial infection during pregnancy for women and newborns, a follow-up study was planned. We ex...

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Section: Discussionmentioning

confidence: 92%

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confidence: 99%

Use of Pooled Urine Samples and Automated DNA Isolation To Achieve Improved Sensitivity and Cost-Effectiveness of Large-Scale Testing for Chlamydia trachomatis in Pregnant Women

et al. 2005

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“…25 It has also been found that serum IgM antibodies, but not IgG antibodies, are associated with preterm delivery, suggesting that acute infection may play a role. 26 We examined the appearance of C. trachomatis IgG antibodies retrospectively as a marker of past infection. However, in the case of preterm delivery, these antibodies may appear later.…”

Section: Discussionmentioning

confidence: 99%

Population-Based Study of Prediagnostic Antibodies to Chlamydia trachomatis in Relation to Adverse Pregnancy Outcome

Rantsi

Joki-Korpela

Wikström

et al. 2016

Sexually Transmitted Diseases

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“…Stillbirth, preterm delivery or perinatal death (Dong et al, 1988;Witkin et al, 1992;Fejgin et al, 1997;Gencay et al, 1997Gencay et al, , 2000Ren et al, 1997;Rastogi et al, 1999) as well as neonatal conjunctivitis or pneumonia (Sandstrom et al, 1984;Mardh, 2002) have been reported. Thorp et al (1989) have found that chlamydiae pass through fetal membranes and thus cause pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Chlamydia and mycoplasma infections during pregnancy and their relationships to orofacial cleft

et al. 2006

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Serum antibodies to Mycoplasma pneumoniae and Chlamydia trachomatis have been studied in a group of newborns with orofacial cleft (OC) and their mothers (n = 59) as compared to a control group of healthy newborns and their mothers (n = 40) assayed by ELISA and Western blot analysis. In the first group, IgG antibodies to M. pneumoniae were found by ELISA in 12 newborns with OC and 22 mothers, while IgA antibodies were detected only in 5 and 11 cases, respectively. IgM antibodies indicating an acute infection were found in 2 mothers only. IgG antibodies to C. trachomatis were found in 2 newborns with OC and 4 mothers. In the control group, IgG antibodies to M. pneumoniae were found in 3 newborns and 7 mothers. IgG antibodies to C trachomatis were observed in 1 newborn and 1 mother, while IgM antibodies to C trachomatis were present in 1 mother only. Immunoblot analysis revealed in newborns with OC and their mothers C. trachomatis-specific bands associated with MOMP 1, 29 kDa, 45 kDa, and heat shock proteins (HSP) 60 and 70. Based on these results we suggest that the risk associated with the exposure to M. pneumoniae and/or C. trachomatis is so far unknown and further study is needed for its elucidation.

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Chlamydia trachomatis seropositivity is associated both with stillbirth and preterm delivery

Cited by 56 publications

References 28 publications

Use of Pooled Urine Samples and Automated DNA Isolation To Achieve Improved Sensitivity and Cost-Effectiveness of Large-Scale Testing for Chlamydia trachomatis in Pregnant Women

Use of Pooled Urine Samples and Automated DNA Isolation To Achieve Improved Sensitivity and Cost-Effectiveness of Large-Scale Testing for Chlamydia trachomatis in Pregnant Women

Population-Based Study of Prediagnostic Antibodies to Chlamydia trachomatis in Relation to Adverse Pregnancy Outcome

Chlamydia and mycoplasma infections during pregnancy and their relationships to orofacial cleft

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