<i>Chlamydia trachomatis</i>‐induced cell‐mediated and humoral immune response in women with unexplained infertility

Rantsi, Tiina; Joki-Korpela, Päivi; Öhman, Hanna; Bloigu, Aini; Kalliala, Ilkka; Puolakkainen, Mirja; Paavonen, Jorma; Surcel, Heljä‐Marja; Tiitinen, Aila

doi:10.1111/aji.12865

Cited by 4 publications

(3 citation statements)

References 26 publications

(50 reference statements)

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“…Concerning the four articles that denied the association between CT infection and female infertility, Rantsi et al 18 and Hoenderboom et al 25 do affirm, however, that a longer time to conceive spontaneously was observed in women previously infected. This may indicate that past CT infection reduced the number of ciliated mucosal cells, leading to functional tubal damage and impairing the potential for pregnancy, even if it did not cause tubal occlusion.…”

Section: Discussionmentioning

confidence: 95%

The Correlation between Chlamydia Trachomatis and Female Infertility: A Systematic Review

Passos

Terraciano

Wolf

et al. 2022

Rev Bras Ginecol Obstet

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The impact of Chlamydia trachomatis (CT) infection on female's fertility is not completely established yet, since the level of evidence associating these factors is still weak. Hence, the goal of the present review is to contribute to a better elucidation of this matter. The electronic database chosen was the Medline/PubMed, with the last survey on May 11, 2021. Publication date was used as a filter, with the previous 5 years having been selected. The following describers were used: chlamydia trachomatis AND infertility; chlamydia trachomatis AND tubal alteration AND infertility; chlamydia AND low pregnancy rates. From the 322 studies screened, 293 that failed to meet our eligibility criteria were excluded. Subsequently, we removed seven studies for not having the possible correlation between CT infections and female infertility as its main focus, and three for being about sexually transmitted infections (STIs) in general. Moreover, two studies designed as reviews were also excluded. Ergo, we included 17 studies in our qualitative analysis. The authors conducted research individually and analyzed carefully the studies selected. As we retrieved the information needed for our study through reading the texts, no contact was made with the authors of the studies selected. This systematic review corroborates the hypothesis that CT infection potentiates female infertility, as 76.47% of the included studies found a positive correlation between them. We conclude that there is an important association between CT infection and female infertility. Ergo, making CT screening part of the infertility investigation routine is relevant and has a reasonable justification.

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Section: Discussionmentioning

confidence: 95%

The Correlation between Chlamydia Trachomatis and Female Infertility: A Systematic Review

Passos

Terraciano

Wolf

et al. 2022

Rev Bras Ginecol Obstet

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“…For example, studies conducted by Rantsi et al . 18 19 showed that CT+ women had a longer natural pregnancy time than CT− women, and persistent CT infection led to tubal infertility in women. Tang et al .…”

Section: Discussionmentioning

confidence: 99%

Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China

Zhou

Tang

et al. 2022

Asian Journal of Andrology

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Chlamydia trachomatis (CT) infection is the most prevalent sexually transmitted bacterial disease worldwide. However, unlike that in female infertility, the role of CT infection in male infertility remains controversial. The objective of this retrospective study was to explore the impacts of CT infection in the genital tract on sperm quality, sperm acrosin activity, antisperm antibody levels, and inflammation in a large cohort of infertile males in China. A total of 7154 semen samples were collected from infertile male subjects, 416 of whom were CT positive (CT+ group) and 6738 of whom were CT negative (CT− group), in our hospital between January 2016 and December 2018. Routine semen parameters (semen volume, pH, sperm concentration, viability, motility, morphology, etc.), granulocyte elastase levels, antisperm antibody levels, and sperm acrosin activity were compared between the CT+ and CT− groups. Our results showed that CT infection was significantly correlated with an abnormally low semen volume, as well as an increased white blood cell count and granulocyte elastase level (all P < 0.05) in the semen of infertile males; other routine semen parameters were not negatively impacted. The antisperm antibody level and sperm acrosin activity were not affected by CT infection. These findings suggested that CT infection might contribute to inflammation and hypospermia but does not impair sperm viability, motility morphology, and acrosin activity or generate antisperm antibodies in the infertile males of China.

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“…It has a strong toxic effect on the body. It can destroy the structure of biological macromolecules such as nucleic acid and protein [19]. It is an important physiological index of oxidative stress and lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

Study on the Mechanism of Shenjing Guben Prescription Regulating PI3K and NRF2 Signaling Pathway in the Treatment of Immune Infertility

Liu

Xue

Hui

2022

Evidence-Based Complementary and Alternative Medicine

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Objective. To explore the mechanism of Shenjing Guben prescription (SP) in the treatment of immune infertility by regulating PI3K-NRF2/p38 signal pathway. Methods. 60 adult male SD rats were randomly divided into control group (NC group), ACN group, low concentration AP intervention group (low group), middle concentration SP intervention group (middle group), and high concentration SP intervention group (high group). 12 rats in each group were administered by gavage once a day, 6 days/w, and the rats were killed after 28 days. Bilateral testis and epididymis were removed and weighed and organ coefficients were calculated, and testicular histopathological sections were prepared to evaluate the changes of testicular tissue structure. The relative expression levels of PI3K, MKK7, JNK, p38 mRNA, and protein in testis were measured by QRT-PCR and western blot. Results. (1) Compared with the control group, the proportion of grade A and B sperms in ACN group increased significantly, and the proportion of grade D sperm decreased significantly ( P < 0.05). After SP intervention, compared with ACN group, there was no significant difference in the proportion of sperm at all levels in low, medium, and high SP intervention groups ( P > 0.05). (2) Compared with the control group, the sperm VCL, VSL, VAP, and mad in ACN group increased significantly, and the BCF decreased significantly ( P < 0.05). After SP intervention, compared with ACN group, there was no significant difference in sperm motility parameters among low, medium, and high SP intervention groups ( P > 0.05). (3) Compared with the control group, the activities of AKP and SDH in testicular tissue of rats in ACN group decreased significantly ( P < 0.05). After SP intervention, compared with ACN group, AKP activity increased significantly and LDH activity decreased significantly in low, medium, and high SP intervention groups ( P < 0.05). (4) Compared with the control group, the expression levels of PI3K, p-PI3K, MKK7, p-MKK7, JNK, p-JNK, p38, and p-p38 proteins and the ratios of p-JNK/JNK and p-p38/p38 increased in the testis of ACN group ( P < 0.05). After SP intervention, compared with ACN group, the protein expression levels of PI3K, p-PI3K, MKK7, p-MKK7, JNK, p-JNK, p38, and p-p38 in testicular tissue of SP intervention group decreased, and the ratio of p-JNK/JNK and p-p38/p38 decreased ( P < 0.05). Conclusion. SP can reduce the oxidative stress of testis induced by ACN and inhibit the activation of PI3K-NRF2/p38 signal pathway.

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Chlamydia trachomatis‐induced cell‐mediated and humoral immune response in women with unexplained infertility

Cited by 4 publications

References 26 publications

The Correlation between Chlamydia Trachomatis and Female Infertility: A Systematic Review

The Correlation between Chlamydia Trachomatis and Female Infertility: A Systematic Review

Chlamydia trachomatis infection in the genital tract is associated with inflammation and hypospermia in the infertile male of China

Study on the Mechanism of Shenjing Guben Prescription Regulating PI3K and NRF2 Signaling Pathway in the Treatment of Immune Infertility

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