<i>Chlamydia pneumoniae</i> may be associated with lung cancer:

Koyi, Hirsh; Brandén, Eva; Gnarpe, Judy; Gnarpe, Håkan; Arnholm, Birgitta; Hillerdal, Gunnar

doi:10.1111/j.1699-0463.1999.tb01478.x

Cited by 27 publications

(3 citation statements)

References 21 publications

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“…Recently, a serological association between Chlamydia pneumoniae infection and lung cancer has been found (Laurila et al 1997, Koyi et al 1999. THA and TKA patients are easily treated with antibiotics for respiratory tract and other infections to prevent hematogenous spread of the bacteria to the prosthesis.…”

Section: Gastrointestinal Cancersmentioning

confidence: 99%

Decreased cancer risk in patients who have been operated on with total hip and knee arthroplasty for primary osteoarthrosis

Visuri

Pukkala

Pulkkinen

et al. 2003

Acta Orthopaedica Scandinavica

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Section: Gastrointestinal Cancersmentioning

confidence: 99%

Decreased cancer risk in patients who have been operated on with total hip and knee arthroplasty for primary osteoarthrosis

Visuri

Pukkala

Pulkkinen

et al. 2003

Acta Orthopaedica Scandinavica

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“…C. pneumoniae can localize and infect preferentially to the lungs of smokers [97]. Monocytes secretion of IL-1β, IL-8, superoxide oxygen radicals, and tumor necrosis factor act as mediators of inflammation and can also cause damage to lung tissue and DNA which can result in carcinogenesis [98]. Table 2.…”

Section: Chlamydia Pneumoniaementioning

confidence: 99%

Cancer and Infectious Causes

Smith¹,

Oertle²,

Prato³

2014

OJMM

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Various kinds of organisms, including viruses, bacteria, trematodes and fungi are known carcinogens that cause cancer. Infectious identification related to cancer may lead to better treatment for both the prevention and targeting of cancer therapy. Although nearly 20% of all cancers are caused by an infection of a microbe, the amount of evidence and information regarding the mechanisms associated with oncogenesis varies dramatically from one organism to the next. This review cannot be exhaustive because we are not aware of all infections worldwide in addition to their potential mechanisms for oncogenesis. More research is required for all of the species mentioned in this review.

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“…The radicals of superoxide oxygen, tumor necrosis factor, IL-8 and IL-1β are generated by induced monocytes. The inflammatory factors may trigger the process of carcinogenesis in lung cells (Koyi et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Proteome-wide screening for the analysis of protein targeting of Chlamydia pneumoniae in endoplasmic reticulum of host cells and their possible implication in lung cancer development

Li¹,

Khan²,

Chaudhary³

et al. 2022

Biocell

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Available reports have confirmed a link between bacterial infection and the progression of different types of cancers, including colon, lungs, and prostate cancer. Here we report the Chlamydia pneumonia proteins targeting in endoplasmic reticulum (ER) using in-silico approaches and their possible role in lung cancer etiology. We predicted 48 proteins that target human ER, which may be associated with protein folding and protein-protein interactions during infection. The results showed C. pneumoniae proteins targeting human ER and their implications in lung cancer growth.These targeted proteins may be involved in competitive interactions between host and bacterial proteins, which may change the usual pathway functions and trigger the development of lung cancer. Moreover, C. pneumoniae unfolded protein accumulation in the human ER possibly induces ER stress, consequently activating the unfolded protein response (UPR), and providing a favorable microenvironment for cancer growth. The current study showed the C. pneumoniae protein targeting in ER of host cell and their implication in lung cancer growth. These results may help researchers better manage lung cancer and establish a molecular mechanism for C. pneumoniae lung cancer association.

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Chlamydia pneumoniae may be associated with lung cancer:

Cited by 27 publications

References 21 publications

Decreased cancer risk in patients who have been operated on with total hip and knee arthroplasty for primary osteoarthrosis

Decreased cancer risk in patients who have been operated on with total hip and knee arthroplasty for primary osteoarthrosis

Cancer and Infectious Causes

Proteome-wide screening for the analysis of protein targeting of Chlamydia pneumoniae in endoplasmic reticulum of host cells and their possible implication in lung cancer development

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