<i>Chlamydia Pneumoniae</i> Infection and Cerebral Infarction Risk: A Meta-Analysis

Su, Xing; Chen, Honglin

doi:10.1111/ijs.12248

Cited by 8 publications

(5 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In fact, a significant increase of anti‐ C. pneumoniae antibodies was found in the patients' group, contributing to a two‐fold increase in the risk of stroke. In particular, the IgA seropositivity was significantly higher than IgG in stroke cases, and these results are similar to the findings of recent meta‐analyses . The literature reports a variable stroke risk.…”

Section: Discussionsupporting

confidence: 89%

Previous infection and the risk of ischaemic stroke in Italy: the IN2 study

Consoli

Vidale²,

Aguglia

et al. 2014

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 89%

Previous infection and the risk of ischaemic stroke in Italy: the IN2 study

Consoli

Vidale²,

Aguglia

et al. 2014

Euro J of Neurology

View full text Add to dashboard Cite

show abstract

“…Still, our study found no significant relationship between CVA and IgG and IgM. It could be due to the limitations of our study (24)(25).…”

Section: Discussioncontrasting

confidence: 68%

Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke

Abbas

Masoud

khorshidi

et al. 2022

View full text Add to dashboard Cite

Introduction: Stroke is the third most common cause of mortality and the most common disability disorder among adults. We aimed to study the relationship between Chlamydia pneumonia infection and non-cardio Ambulatory ischemic stroke. Methods: This case-control study was performed on 162 patients with non-cardio ambulatory ischemic stroke admitted to Shahid Beheshti Hospital of Kashan in 2019 as the case group and patients with neurological headache and degenerative diseases as the control group. After filling out the questionnaire for all subjects, we took blood samples. We analyzed all three anti-chlamydia pneumonia antibodies (IgM, IgG, IgA) by ELISA method after data were analyzed by Chi-square and Fisher tests. Results: The findings of this study showed that positive IgA in the stroke group was significantly higher than in the control group (p=0.001); it was also found that the risk factors of HTN (p=0.001), HLP (p=0.001), DM (p=0.001), and age (p = 0.049) were significantly higher in the stroke patients' group than the control group. On the other hand, there was not a significant difference in serum IgG level (p = 0.349), IgM (p = 0.745), smoking (p = 0.211) and gender (p = 0.157) in understudied groups. Conclusion: Chlamydia IgA antibodies can be a complementary tool for predicting prognosis and monitoring new therapies for ischemic stroke. This study provides a way for further studies, especially with other markers of acute and chronic systemic Chlamydia pneumonia infection. Antibiotic treatment significantly helps to reduce mortality and stroke complications.

show abstract

“…C. pneumoniae is also associated with cerebrovascular disease and cerebral infarction (stroke). A recent meta-analysis suggested that cerebral infarction patients were significantly more likely to be seropositive for C. pneumoniae infection compared to healthy controls (Su and Chen, 2014).…”

Section: Bacterial Pathogens Associated With Neurodegenerationmentioning

confidence: 99%

Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

Patrick

Bell

Weindel

et al. 2019

Front. Cell. Infect. Microbiol.

View full text Add to dashboard Cite

Despite major strides in personalized genomics, it remains poorly understood why neurodegenerative diseases occur in only a fraction of individuals with a genetic predisposition and conversely, why individuals with no genetic risk of a disorder develop one. Chronic diseases like Alzheimer's, Parkinson's, and Multiple sclerosis are speculated to result from a combination of genetic and environmental factors, a concept commonly referred to as the “multiple hit hypothesis.” A number of bacterial infections have been linked to increased risk of neurodegeneration, and in some cases, clearance of bacterial pathogens has been correlated with amelioration of central nervous system (CNS) deficits. Additionally, mutations in several genes known to contribute to CNS disorders like Parkinson's Disease have repeatedly been implicated in susceptibility to intracellular bacterial infection. Recent data has begun to demonstrate roles for these genes ( PARK2, PINK1 , and LRRK2 ) in modulating innate immune outcomes, suggesting that immune dysregulation may play an even more important role in neurodegeneration than previously appreciated. This review will broadly explore the connections between bacterial infection, immune dysregulation, and CNS disorders. Understanding this interplay and how bacterial pathogenesis contributes to the “multiple-hit hypothesis” of neurodegeneration will be crucial to develop therapeutics to effectively treat both neurodegeneration and infection.

show abstract

Chlamydia Pneumoniae Infection and Cerebral Infarction Risk: A Meta-Analysis

Cited by 8 publications

References 39 publications

Previous infection and the risk of ischaemic stroke in Italy: the IN2 study

Previous infection and the risk of ischaemic stroke in Italy: the IN2 study

Association between infection with Chlamydia pneumonia and cerebral noncardioembolic ischemic stroke

Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

Contact Info

Product

Resources

About