<i>CFHR2</i>‐rs2986127 as a genetic protective marker for acute anterior uveitis in Chinese patients

Huang, Xiu‐Feng; Wang, Yuqin; Li, Fenfen; Lin, Dan; Wang, Qingfeng; Jin, Zi‐Bing

doi:10.1002/jgm.2890

Cited by 7 publications

(3 citation statements)

References 25 publications

(22 reference statements)

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“…Another key component is the complement system, which is also involved in innate immunity and inflammatory responses. Genetic associations of complement factor H (CFH), complement factor B (CFB), complement factor I (CFI) and complement factor H related 2 (CFHR2) have been reported [ 8 , 20 – 23 ]. Notably, CFB localizes to the MHC class III region.…”

Section: Acute Anterior Uveitismentioning

confidence: 99%

Progress in the genetics of uveitis

Huang

Brown

2022

Genes Immun

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Uveitis is the most common form of intraocular inflammatory disease and is a significant cause of visual impairment worldwide. Aetiologically, uveitis can also be classified into infectious uveitis and non-infectious uveitis. The common non-infectious forms of uveitis include acute anterior uveitis (AAU), Behçet’s disease (BD), Vogt-Koyanagi-Harada (VKH) disease, birdshot chorioretinopathy (BSCR), sarcoid uveitis. In addition, a few monogenic autoinflammatory disorders can also cause uveitis, such as Blau Syndrome and haploinsufficiency of A20 (HA20). Although the exact pathogenesis of non-infectious uveitis is still unclear, it is well-recognised that it involves both genetic and environmental risk factors. A hallmark of uveitis is its strong associations with human leucocyte antigens (HLA). For examples, AAU, BD and BSCR are strongly associated with HLA-B27, HLA-B51, and HLA-A29, respectively. In uveitis studies, multiple GWAS have successfully been conducted and led to identification of novel susceptibility loci, for example, IL23R has been identified in BD, VKH and AAU. In this review, we summarize the latest progress on the genetic associations of both HLA and non-HLA genes with major forms of uveitis, including AAU, BD, VKH, BSCR, sarcoid uveitis, Blau Syndrome and HA20, and potential future research directions.

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Section: Acute Anterior Uveitismentioning

confidence: 99%

Progress in the genetics of uveitis

Huang

Brown

2022

Genes Immun

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“…We detected that the serum levels of immunoglobulins, including complement factor H, complement component C8 alpha chain, complement factor I, complement factor H-related protein 3 (Fragment), complement component C6, complement factor B, complement C5, and properdin were lower in LA and MA buffalo than in HA buffalo ( Table 1 ). Complement factor H is a member of the complement regulator and plays an important role in complement activation pathways [ 31 ].…”

Section: Discussionmentioning

confidence: 99%

Physiological and Proteomic Responses of Dairy Buffalo to Heat Stress Induced by Different Altitudes

Lan

Cao²,

Yang³

et al. 2022

Metabolites

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Buffalo are mainly distributed in low-altitude (LA), medium-altitude (MA), and high-altitude (HA) regions characterised by different thermal and oxygen environments in Yunnan province, China. Due to black skin, sparse hair, and the low density of skin sweat glands, buffalo are more sensitive to heat stress. Here, we used data-independent acquisition (DIA) proteomics to reveal a broad spectrum of proteins that play roles in adaptation to the heat stress of buffalo raised at low altitude or hypoxia at high altitude. LA buffalo showed higher body temperatures than MA- and HA buffalo, and HA buffalo had higher levels of GSH and SOD and lower levels of ROS compared to LA and MA buffalo. In 33 samples, 8476 peptides corresponding to 666 high-confidence proteins were detected. The levels of circulating complement proteins in the immune pathways were lower in LA and MA buffalo than in HA buffalo. There were higher levels of alpha-1 acid glycoprotein in LA buffalo than in MA and HA buffalo. Relative to MA buffalo, levels of blood oxygen delivery proteins were higher in LA and HA buffalo. A higher abundance of apolipoproteins was detected in LA and MA buffalo than in HA buffalo. In summary, buffalo adopted similar adaptation strategies to oxidative stress induced by heat stress or hypoxia, including immunological enhancement, high efficiency of blood oxygen delivery, and the inhibition of lipid oxidation.

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“…31,32 Studies have shown that CFHR2 is important in the gender difference in the incidence of acute anterior uveitis. 33 In addition, it has a wide range of applications in terms of resistance to pathogen invasion and pulmonary arterial hypertension associated with congenital heart disease. 34 However, there have been no studies investigating the roles of CFHR1 and CFHR2 in tuberculosis, especially osteoarticular tuberculosis.…”

Section: Discussionmentioning

confidence: 99%