<i>Centella asiatica</i> accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro

Soumyanath, Amala; Zhong, Yong; Gold, Sandra A.; Yu, Xiaolin; Koop, Dennis R.; Bourdette, Dennis; Gold, Bruce G.

doi:10.1211/jpp.57.9.0018

Cited by 141 publications

(104 citation statements)

References 38 publications

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“…Centella asiatica also decreases Aβ deposition in the brain. Chen et al carried out a study which suggested that Centella asiatica ethanol extract can suppress Aβ-induced neurotoxicity by enhancing the antioxidative defence system in differentiated PC12 and IMR32 cells [29,30]. Amelioration of the colchicine-induced decrease in AChE activity and inhibition of nitric oxide induced neuronal damage by asiaticoside may also explain the neuroprotective effect of Centella asiatica [31,32].…”

Section: Centella Asiaticamentioning

confidence: 99%

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Roy

Awasthi

2017

Int J Pharm Pharm Sci

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Neurodegeneration refers to a condition of neuronal death occurring as a result of progressive disease of long-term and is becoming a major health problem in the 21st century. Neurons degenerated are not replaced resulting in a cognitive loss, many neurodegenerative disorders, such as schizophrenia, depression, Alzheimer's disease (AD), dementia, cerebrovascular impairment, seizure disorders, head injury, parkinsonism. The common pathology of neurodegeneration includes deposition of misfolded proteins such as amyloid-β (Aβ) in Alzheimer's disease, α-synuclein in Parkinson's disease (PD), transactive response DNA-binding protein 43 (TDP-43) in dementia. Neuroprotection refers to the strategies and possible mechanisms that are able to protect the central nervous system (CNS) against neuronal injury and neurodegenerative disorders. The past decade has witnessed an intense interest in herbal plants having long-term health-promoting or medicinal qualities. Comprehensive research and discovery have demonstrated that natural products, medicinal herbs, plant extracts, and their metabolites, have great potential as the neuroprotective agent. Although the precise mechanisms of action of herbal drugs have yet to be determined, some of them have been shown to prevent formation of betaamyloid plaques, promote nerve growth, some inhibit acetylcholinesterase (AChE) enzyme and malondialdehyde (MDA) formation in brain while other exhibits antioxidant activity by increasing the level of superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx). Thus the herbal plants can be a valuable source of the drug against neurodegenerative disorders which will require high-throughput screening. This review will highlight the role of herbal plants and their phytoconstituents against neurodegenerative diseases and other related disorders, focusing on their mechanism of action and therapeutic potential.

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Section: Centella Asiaticamentioning

confidence: 99%

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Roy

Awasthi

2017

Int J Pharm Pharm Sci

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“…Recent findings suggest that Centella asiatica has cognition-enhancing properties through its ability to protect against oxidative stress [10,11] , reduce the extent of mitochondrial damage [12] and increase axonal regeneration and neurite elongation [13] . Asiatic acid (AA) is a pentacyclic triterpene found in Centella asiatica.…”

Section: Introductionmentioning

confidence: 99%

Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells

et al. 2012

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Aim: To investigate whether asiatic acid (AA), a pentacyclic triterpene in Centella asiatica, exerted neuroprotective effects in vitro and in vivo, and to determine the underlying mechanisms. Methods: human neuroblastoma Sh-SY5Y cells were used for in vitro study. Cell viability was determined with the MTT assay. hoechst 33342 staining and flow cytometry were used to examine the apoptosis. The mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) were measured using fluorescent dye. PGC-1α and Sirt1 levels were examined using Western blotting. Neonatal mice were given monosodium glutamate (2.5 mg/g) subcutaneously at the neck from postnatal day (PD) 7 to 13, and orally administered with AA on PD 14 daily for 30 d. The learning and memory of the mice were evaluated with the Morris water maze test. hE staining was used to analyze the pyramidal layer structure in the CA1 and CA3 regions. Results: Pretreatment of Sh-SY5Y cells with AA (0.1-100 nmol/L) attenuated toxicity induced by 10 mmol/L glutamate in a concentration-dependent manner. AA 10 nmol/L significantly decreased apoptotic cell death and reduced reactive oxygen species (ROS), stabilized the mitochondrial membrane potential (MMP), and promoted the expression of PGC-1α and Sirt1. In the mice models, oral administration of AA (100 mg/kg) significantly attenuated cognitive deficits in the Morris water maze test, and restored lipid peroxidation and glutathione and the activity of SOD in the hippocampus and cortex to the control levels. AA (50 and 100 mg/kg) also attenuated neuronal damage of the pyramidal layer in the CA1 and CA3 regions. Conclusion: AA attenuates glutamate-induced cognitive deficits of mice and protects SH-SY5Y cells against glutamate-induced apoptosis in vitro.

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“…Based on the previous findings that Ginkgo biloba extract or EGb761 and Centella asiatica could improve the functional recovery of peripheral nerve by increasing the total number of myelinated axons in nerve (Hsu et al, 2004;Soumyanath et al, 2005), therefore, this study also determines the axonal density. Our results have also demonstrated the increase in density of axons in sciatic nerve after crush injury which in agreement with previous works.…”

Section: Discussionmentioning

confidence: 99%

<i>Morus alba</i> Enhanced Functional Recovery After Sciatic Nerve Crush Injury

Mucimapura¹,

Thongrong²,

Chaisiwamongkol³

et al. 2010

American Journal of Agricultural and Biological Sciences

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Problem statement: Traumatic nerve injury has been recognized as one of the problems commonly found in road traffic crashes. Therefore, searching for the effective substances for promoting the functional recovery of nerve after injury is in required. Accumulating lines of evidence show that free radicals generated after injury contribute the important role to retard functional recovery, thus the substance possessing anti-oxidant could facilitate functional recovery. Based on the effect of antioxidant to promote functional recovery of nerve after injury mentioned earlier, we hypothesized that Morus alba extract, a substance possessing anti-oxidant activity, should be able to facilitate the functional recovery of peripheral nerve after injury. Approach: To elucidate this issue, male Wistar rats, weighing 180-220 g, were orally given the aqueous extract of Morus alba at various doses ranging from 0.1, 1 and 10 mg kg −1 BW 5days before and 21 days after sciatic nerve injury.Motor, sensory and sensorimotor coordination were observed every 3 days for 3 weeks by using De Medinacelli method, foot reflex withdrawal test and rotarod test, respectively. Results: The low dose of the extract significantly improved both sensory and motor functions after crush injury. Although sensory function recovers more sooner than the motor function, it fails to show full recovery within weeks. Thus, the present study demonstrates the potential of M. alba extract to enhance functional recovery after crush injury. Conclusion: In conclusion, Morus alba may serve as functional food to promote nerve recovery after injury. However, further studies about the possible active ingredient (s) and underlying mechanism (s) are required.

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Centella asiatica accelerates nerve regeneration upon oral administration and contains multiple active fractions increasing neurite elongation in-vitro

Cited by 141 publications

References 38 publications

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Herbal Medicines as Neuroprotective Agent: A Mechanistic Approach

Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells

<i>Morus alba</i> Enhanced Functional Recovery After Sciatic Nerve Crush Injury

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