Cell-specific signal transduction pathways regulating Na+-K+-ATPase. Focus on “Short-term effects of thyroid hormones on the Na+-K+-ATPase activity of chick embryo hepatocytes during development: focus on signal transduction”

Lei, Jianxun; Bhargava, Maneesh; Ingbar, David H.

doi:10.1152/ajpcell.00553.2008

Cited by 17 publications

(4 citation statements)

References 21 publications

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“…The induction of COX-2 is dependent upon p53-mediated activation of the MAPK pathway. These pathways are inhibited by ouabain (12,69,70). In line with this, the Na + /K + -ATPase is considered a target for the treatment of cancer and tissue fibrosis.…”

Section: Genomic and Nongenomic Actions Of Thyroid Hormonesmentioning

confidence: 87%

“…These effects are characterized by a time-course of seconds to minutes, and do not rely on the interaction with the nuclear receptors. The receptor protein differs according to the cell type and it can be nuclear or cytosolic (5)(6)(7)(8)(9)(10)(11)(12)(13)(14). The avb3 integrin acts as a thyroid hormone receptor on the cell membrane, and many rapid effects have been reported to be mediated by this integrin (15).…”

Section: Genomic and Nongenomic Actions Of Thyroid Hormonesmentioning

confidence: 99%

“…This type of regulation of the Na + pump is mainly achieved by:1) Cyclic AMP that activates Protein Kinase A (PKA); 2) Diacylglycerol, endogenous activator of Protein Kinase C (PKC); 3) Phosphatidyl inositol 3-kinase (PI3K); 4) Intracellular Ca 2+ increase and activation of Calmodulin Kinase (37, 38). It should be recalled at this point that the Na + /K + -ATPase is not only an important and ubiquitous pump that maintains the unequal distribution of ions across the plasma membrane, but it is also a "signal transducer" able to modulate important physiological responses such as growth, apoptosis, cell adhesion and migration (12). In this regard, the inhibition of the Na + pump by ouabain and other cardioactive steroids is a way to modulate not only ion gradient across the plasma membrane, but also a possible pharmacological tool in case of cancer, viral infection and other pathologies (12,38,39).…”

Section: Genomic and Nongenomic Actions Of Thyroid Hormonesmentioning

confidence: 99%

“…It should be recalled at this point that the Na + /K + -ATPase is not only an important and ubiquitous pump that maintains the unequal distribution of ions across the plasma membrane, but it is also a "signal transducer" able to modulate important physiological responses such as growth, apoptosis, cell adhesion and migration (12). In this regard, the inhibition of the Na + pump by ouabain and other cardioactive steroids is a way to modulate not only ion gradient across the plasma membrane, but also a possible pharmacological tool in case of cancer, viral infection and other pathologies (12,38,39).…”

Section: Genomic and Nongenomic Actions Of Thyroid Hormonesmentioning

confidence: 99%

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Extranuclear effects of thyroid hormones and analogs during development: An old mechanism with emerging roles

et al. 2022

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Thyroid hormones, T3 (triiodothyronine) and T4 (thyroxine), induce a variety of long-term effects on important physiological functions, ranging from development and growth to metabolism regulation, by interacting with specific nuclear or cytosolic receptors. Extranuclear or nongenomic effects of thyroid hormones are mediated by plasma membrane or cytoplasmic receptors, mainly by αvβ3 integrin, and are independent of protein synthesis. A wide variety of nongenomic effects have now been recognized to be elicited through the binding of thyroid hormones to this receptor, which is mainly involved in angiogenesis, as well as in cell cancer proliferation. Several signal transduction pathways are modulated by thyroid hormone binding to αvβ3 integrin: protein kinase C, protein kinase A, Src, or mitogen-activated kinases. Thyroid hormone-activated nongenomic effects are also involved in the regulation of Na+-dependent transport systems, such as glucose uptake, Na+/K+-ATPase, Na+/H+ exchanger, and amino acid transport System A. Of note, the modulation of these transport systems is cell-type and developmental stage-dependent. In particular, dysregulation of Na+/K+-ATPase activity is involved in several pathological situations, from viral infection to cancer. Therefore, this transport system represents a promising pharmacological tool in these pathologies.

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Section: Genomic and Nongenomic Actions Of Thyroid Hormonesmentioning

confidence: 87%

Section: Genomic and Nongenomic Actions Of Thyroid Hormonesmentioning

confidence: 99%

Section: Genomic and Nongenomic Actions Of Thyroid Hormonesmentioning

confidence: 99%

Section: Genomic and Nongenomic Actions Of Thyroid Hormonesmentioning

confidence: 99%

See 2 more Smart Citations

Extranuclear effects of thyroid hormones and analogs during development: An old mechanism with emerging roles

et al. 2022

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Local Motility, Flow and Mixing in Tubular Segments of the Gut

Lentle

Janssen

2011

The Physical Processes of Digestion

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A review of mixing and propulsion of chyme in the small intestine: fresh insights from new methods

Lentle

Loubens

2015

J Comp Physiol B

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The small intestine is a convoluted flexible tube of inconstant form and capacity through which chyme is propelled and mixed by varying patterns of contraction. These inconstancies have prevented quantitative comparisons of the manner in which contractile activity engenders mixing of contained chyme. Recent quantitative work based on spatiotemporal mapping of intestinal contractions, macro- and micro-rheology, particle image velocimetry and real-time modelling has provided new insights into this process. Evidence indicates that the speeds and patterns of the various types of small intestinal contraction are insufficient to secure optimal mixing and enzymatic digestion over a minimal length of intestine. Hence particulate substrates and soluble nutrients become dispersed along the length of the lumen. Mixing within the lumen is not turbulent but results from localised folding and kneading of the contents by contractions but is augmented by the inconstant spatial disposition of the contractions and their component contractile processes. The latter include inconstancies in the sites of commencement and the directions of propagation of contraction in component groups of smooth muscle cells and in the coordination of the radial and circular components of smooth muscle contraction. Evidence suggests there is ongoing augmentation of mixing at the periphery of the lumen, during both the post-prandial and inter-meal periods, to promote flow around and between adjacent villi. This results largely from folding of the relatively inelastic mucosa during repeated radial and longitudinal muscular contraction, causing chyme to be displaced by periodic crowding and separation of the tips of the relatively rigid villi. Further, micro-rheological studies indicate that such peripheral mixing may extend to the apices of enterocytes owing to discontinuities in the mobile mucus layer that covers the ileal mucosa.

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Cell-specific signal transduction pathways regulating Na⁺-K⁺-ATPase. Focus on “Short-term effects of thyroid hormones on the Na⁺-K⁺-ATPase activity of chick embryo hepatocytes during development: focus on signal transduction”

Cited by 17 publications

References 21 publications

Extranuclear effects of thyroid hormones and analogs during development: An old mechanism with emerging roles

Extranuclear effects of thyroid hormones and analogs during development: An old mechanism with emerging roles

Local Motility, Flow and Mixing in Tubular Segments of the Gut

A review of mixing and propulsion of chyme in the small intestine: fresh insights from new methods

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