CDH1 Genotype Exploration in Women With Hereditary Lobular Breast Cancer Phenotype
Giovanni Corso,
Elena Marino,
Cristina Zanzottera
et al.
Abstract:ImportancePathogenic or likely pathogenic (P/LP) germline CDH1 variants are associated with risk for diffuse gastric cancer and lobular breast cancer (LBC) in the so-called hereditary diffuse gastric cancer (HDGC) syndrome. However, in some circumstances, LBC can be the first manifestation of this syndrome in the absence of diffuse gastric cancer manifestation.ObjectivesTo evaluate the frequency of germline CDH1 variants in women with the hereditary LBC (HLBC) phenotype, somatic CDH1 gene inactivation in germl… Show more
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