<i>CD209</i>Promoter Single Nucleotide Polymorphism -336A/G and the Risk of Susceptibility to Tuberculosis Disease in the Moroccan Population

Sadki, Khalid; Lamsyah, H.; Rueda, Blanca; Lahlou, Ouafae; Aouad, Rajae El; Martín, Javier

doi:10.1080/09723757.2009.11886073

Cited by 6 publications

(3 citation statements)

References 23 publications

(31 reference statements)

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“…The frequency of SNP -336A/G in some African regions, such as in South Africa (40.3%) and Guinea-Bissau (49.9%), is considerably higher than the frequency found in this study (P < 0.05) (Barreiro et al, 2006;Olesen et al, 2007). However, in some northern African countries, such as Tunisia and Morocco, the frequency of this polymorphism is not statistically different from that of European countries (Ben-Ali et al, 2007;Sadki et al, 2009). Moreover, the frequency of allele -336G observed in this study was significantly higher than the frequency observed in Asian populations, such as those of eastern China (7.3%) (Zheng et al, 2011), northern Thailand (9.5%) (Wichukchinda et al, 2007), and different regions of Taiwan (Table 2).…”

Section: Discussioncontrasting

confidence: 50%

Frequency of SNP -336A/G in the promoter region of CD209 in a population from northeastern Brazil

Pn¹,

Ferreira-Fernandes²,

Js³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. Dendritic cells (DCs) mediate the initiation of the immune response against a variety of pathogens. The DC-SIGN receptor is encoded by the gene CD209 and is expressed on the surface of DCs. It binds to mannose-rich carbohydrates and enables the recognition of bacteria, fungi, parasites, and viruses. SNP -336A/G in the promoter region of CD209 influences the expression of the DC-SIGN receptor. Several studies have associated this SNP with an increased susceptibility to infectious diseases and the development of more severe forms of disease. Therefore, the aim of this study was to determine the prevalence of SNP -336A/G in a population from northeastern Brazil. We analyzed 181 individuals from the general population of Parnaíba, Piauí, Brazil, of which 37% were men and 63% were women. SNP -336A/G was detected by polymerase chain reaction and treatment with the restriction enzyme MscI and visualized by electrophoresis on an 8% polyacrylamide gel stained with silver nitrate. Of the individuals analyzed, 116 (64.1%) were homozygous AA, 57 (31.5%) were heterozygous (AG), and 8 (4.4%) were homozygous GG. The allele frequency of -336G was 20.2%. Genotype frequencies were in Hardy-Weinberg equilibrium. To the best of our knowledge, this is the first report to describe the frequency of the CD209 SNP -336A/G in a population in the State of Piauí. Further studies are needed to determine the relationship between this SNP and the vulnerability of this population to major infectious diseases.

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Section: Discussioncontrasting

confidence: 50%

Frequency of SNP -336A/G in the promoter region of CD209 in a population from northeastern Brazil

Pn¹,

Ferreira-Fernandes²,

Js³

et al. 2015

Genet. Mol. Res.

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“…The CD209 gene, encoding DC-SIGN, might play a crucial role in the pathogenesis of TB. The association between CD209 gene polymorphisms and TB risk was first reported in a South African populations by Barreiro et al [6]; however, as discussed above, conflicting data regarding the role of CD209 in TB susceptibility and presentation have been reported [12]–[15], [19]. Against this backdrop, we performed a meta-analysis to clarify the relationship between CD209 polymorphisms and TB risk.…”

Section: Discussionmentioning

confidence: 85%

Association between CD209 -336A/G and -871A/G Polymorphisms and Susceptibility of Tuberculosis: A Meta-Analysis

Chang

Deng

et al. 2012

PLoS ONE

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BackgroundThe association between CD209 promoter polymorphisms (-336A/G, -871A/G) and tuberculosis (TB) risk has been widely reported, but results of previous studies remain controversial and ambiguous. To assess the association between CD209 polymorphisms and TB risk, a meta-analysis was performed.MethodsBased on comprehensive searches of the PubMed, Embase, Web of Science, Weipu, and CBM databases, we identified outcome data from all articles estimating the association between CD209 polymorphisms and TB risk. The pooled odds ratio (OR) with 95% confidence intervals (CIs) were calculated.ResultsA total of 14 studies with 3,610 cases and 3,539 controls were identified. There was no significant association between CD209 -336A/G polymorphism and TB risk (OR = 1.04, 95% CI = 0.91–1.19 for G vs. A; OR = 1.13, 95% CI = 0.84–1.53 for GG vs. AA; OR = 1.04, 95% CI = 0.87–1.24 for GG+AG vs. AA; OR = 1.11, 95% CI = 0.88–1.39 for GG vs. AG+AA). However, the significant association was revealed for Asians in GG vs. AA (OR = 2.48, 95% CI = 1.46–4.22, P = 0.0008) and GG vs. AG+AA (OR = 2.10, 95% CI = 1.33–3.32, P = 0.001). For the CD209 -871A/G polymorphism, lack of an association was also found (OR = 0.81, 95% CI = 0.70–0.95 for G vs. A; OR = 1.00, 95% CI = 0.52–1.93 for GG vs. AA; OR = 0.73, 95% CI = 0.60–0.89 for GG+AG vs. AA; OR = 1.09, 95% CI = 0.57–2.10 for GG vs. AG+AA).ConclusionThe present meta-analysis suggested that CD209 promoter polymorphisms (-336A/G, -871A/G) were unlikely to substantially contribute to TB susceptibility. However, the GG genotype of CD209 -336A/G polymorphism might be a genetic risk factor that increases TB susceptibility for Asians in GG vs. AA and GG vs. AG+AA.

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“…The most extensively investigated relevant polymorphisms were CD209 ‐336A/G and ‐871A/G. A case–control study conducted by Sadki and colleagues revealed no statistically significant association between ‐336A/G polymorphism and pulmonary TB (Sadki et al., ). This finding is in agreement with results reported in Tunisian, north‐western Colombian, West African and eastern Chinese populations (Ben‐Ali et al., ; Gómez et al., ; Olesen et al., ; Yi, Zhang, Mo, Zhen, & Zhao, ; Zheng et al., ).…”

Section: Candidate Genes and The Risk Of Developing Tbmentioning

confidence: 99%

Current immunogenetic predisposition to tuberculosis in the Moroccan population

Qrafli

Najimi

Elaouad

et al. 2017

Int J Immunogenetics

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Tuberculosis (TB) is a serious infectious disease that kills approximately two million people per year, particularly in low- and middle-income countries. Numerous genetic epidemiology studies have been conducted of many ethnic groups worldwide and have highlighted the critical impact of the genetic environment on TB distribution. Many candidate genes associated with resistance or susceptibility to TB have been identified. In Morocco, where TB is still a major public health problem, various observations of clinical, microbiological and incidence distribution are heavily affected by genetic background and external environment. Morocco has almost the same clinical profile as do other North African countries, mainly the increase in more extrapulmonary than pulmonary forms of the diseases, when compared to European, Asian or American populations. In addition, a linkage analysis study that examined Moroccan TB patients identified a unique chromosome region that had a strong association with the risk of contracting TB. Other genes in the Moroccan population that were found to be associated seem to be involved predominantly in modulating the innate immunity. In this review, we appraise the major candidate genes that have been reported in Moroccan immunogenetic studies and discuss their updated role in TB, particularly during the first phase of the immune response to Mycobacterium tuberculosis (Mtb) infection.

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CD209Promoter Single Nucleotide Polymorphism -336A/G and the Risk of Susceptibility to Tuberculosis Disease in the Moroccan Population

Cited by 6 publications

References 23 publications

Frequency of SNP -336A/G in the promoter region of CD209 in a population from northeastern Brazil

Frequency of SNP -336A/G in the promoter region of CD209 in a population from northeastern Brazil

Association between CD209 -336A/G and -871A/G Polymorphisms and Susceptibility of Tuberculosis: A Meta-Analysis

Current immunogenetic predisposition to tuberculosis in the Moroccan population

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