CD14−550 C/T, Which Is Related to the Serum Level of Soluble CD14, Is Associated with the Development of Respiratory Syncytial Virus Bronchiolitis in the Japanese Population

Abstract

CD14 -550 C/T, which is related to the serum level of sCD14, is associated with the development of RSV bronchiolitis in the Japanese population. This study's results indicate that, in different ethnic groups, different genetic factors contribute to the development of RSV bronchiolitis.

TLR4 genotype and environmental LPS mediate RSV bronchiolitis through Th2 polarization

“…To determine whether CD14 affected RSV disease severity, we asked whether the CD14 C-159T and CD14 C-550T SNPs were also associated with RSV bronchiolitis (Figure 1, F and G, and Supplemental Table 8). Allelic frequencies for both SNPs were in Hardy-Weinberg equilibrium and did not differ from those reported previously (16,17,31). Unlike TLR4 Asp299Gly, CD14 C-159T and CD14 C-550T did not affect RSV disease severity.…”

“…Control subjects included infants with oxygen saturation at or above 93% while breathing room air. In addition, these criteria allow comparison with numerous previous studies (15)(16)(17)(18)(19).…”

“…Environmental exposure (15,19), lack of power (17)(18)(19), choice of controls (15)(16)(17)(18)(19), or specific genetic or demographic characteristics of the population (16) may explain the differences between human studies. In fact, our observations and those of others (47) suggest that the effect of TLR4 in disease severity does not occur through interaction of this PRR with the virus but rather through prior environmental TLR4 activation conditioning the immune response to infection.…”

Major Histocompatibility Complex-Dependent Cytotoxic T Lymphocyte Repertoire and Functional Avidity Contribute to Strain-Specific Disease Susceptibility after Murine Respiratory Syncytial Virus Infection

“…Viral, host, and environmental factors probably all contribute to this variable disease expression, but the relative roles of these factors in human RSV disease remain difficult to evaluate. A series of recent genetic association studies have suggested that polymorphisms in a range of genes encoding cytokines, chemokines, surfactant proteins, or toll-like receptors influence the disease phenotype in humans (1,8,19,21,23,35,45,52,57). However, it remains unclear how and to what extent these factors contribute to disease pathogenesis.…”

Πολυμορφισμοί Των TLR2 Και TLR4 Στη Χρόνια Αποφρακτική Πνευμονοπάθεια

“…Επίσης, ανάλογη µελέτη σε Ιάπωνες δεν πέτυχε να ανιχνεύσει τους δύο πολυµορφι-σµούς σε κανένα από τα εξεταζόµενα άτοµα [191].…”