CCR5 genetic variants and epidemiological determinants for HPV infection and cervical premalignant lesions

Abstract

Human papillomavirus (HPV) infection can lead to the development of productive epithelial lesions and cervical cancer. Most cervical HPV infections are solved by cell‐mediated immunity within 1–2 years, and it is known that chronic inflammation predisposes to lesions progression and tumour development. In this context, we highlight the CC chemokine receptor 5 (CCR5) which is involved in leucocytes chemotaxis to sites of inflammation, controlling the immune response. The CCR5 rs333 genotyping of 164 HPV infected women and 185 non‐infected women was performed using polymerase chain reaction (PCR). HPV infection was more frequent among women under 34 years old (p < 0.001), single (p = 0.001), that received 1 minimum wage or less (p = 0.002), tobacco smokers (p = 0.007), who had the first sexual intercourse before 17 years old (p = 0.038) and that had 4 or more sexual partners during lifetime (p = 0.001). No significant difference regarding genotypes and alleles distribution according to HPV infection was observed. CCR5/CCR5 genotype was observed in 94.1% of HPV non‐infected women and in 89% of infected ones, CCR5/Δ32 in 5.9% of HPV infected and in 10.4% of non‐infected women, and Δ32/Δ32 was observed in only one (0.6%) infected patient. CCR5 genotypes were also not associated with cervical lesions development among HPV infected women (p = 0.167). Since CCR5 may control the antitumour immune response and cervical lesions and the studied rs333 polymorphism is not very frequent, other studies are necessary, in order to establish CCR5 role on HPV infection and squamous intraepithelial lesions development.

Beyond HIV infection: Neglected and varied impacts of CCR5 and CCR5Δ32 on viral diseases

“…CCR5Δ32 homozygous genotype was associated with increased susceptibility to HPV infection in a study performed with Swedish individuals (Zheng et al, 2006). Mangieri et al (2019) investigated the potential influence of CCR5Δ32 on susceptibility to HPV infection and cervical lesions in Brazilian women. However, the genetic variant was not significantly associated with susceptibility to HPV infection (considering allele frequency, codominant model and dominant model) or HPV-associated lesions (Mangieri et al, 2019).…”

“…Mangieri et al (2019) investigated the potential influence of CCR5Δ32 on susceptibility to HPV infection and cervical lesions in Brazilian women. However, the genetic variant was not significantly associated with susceptibility to HPV infection (considering allele frequency, codominant model and dominant model) or HPV-associated lesions (Mangieri et al, 2019). In accordance, previous studies performed with Brazilian women did not find an association between CCR5Δ32 and susceptibility to HPV infection (Suzuki et al, 2008) or between the polymorphism and HPV-related cervical lesions (Suzuki et al, 2008;Santos et al, 2016).…”

CCR5Δ32 in Brazil: Impacts of a European Genetic Variant on a Highly Admixed Population

“…HPV is strongly associated with the development of cervical cancer (157) and it was suggested that CCR5 could play a role in the context of HPV infection and related diseases. Nevertheless, Mangieri et al (158) observed no significant effect of CCR5D32 on susceptibility to the infection or cervical lesions (158). Also, the CCR5D32 was not associated with infection by a particular HPV genotype (159).…”