catena-Poly[[[aqua(pyrazine-2-carboxamide-κ²N¹,O)zinc]-μ-pyrazine-2-carboxamide-κ³N¹,O:N⁴] dinitrate]

Abstract

In the crystal of the title compound, {[Zn(C5H5N3O)2(H2O)](NO3)2}n, the ZnII cation is N,O-chelated by two pyrazine-2-carboxamide (PCA) ligands and is further coordinated by one water mol­ecule and by one pyrazine-N atom from an adjacent PCA ligand in a distorted ZnN3O3 octa­hedral geometry. One of the two independent PCA ligands bridges two ZnII cations, forming a zigzag polymeric chain running along the c axis. In the crystal, the NO3 − anions link to the chain via O—H⋯O and N—H⋯O hydrogen bonding. Weak inter­molecular C—H⋯O inter­actions also occur.

Antimicrobial Activity of Pyrazinamide Coordination Frameworks Synthesized by Mechanochemistry

“…The neat grinding reaction of pyrazinamide with zinc nitrate led to the formation of [Zn(PYR) 2 (H 2 O)](NO 3 ) 2 , compound 1 . The comparison between the experimental PXRD pattern of 1 with the simulated pattern of HAYKUP ( Figure S1 ) clearly confirmed the reproduction of the form reported previously [ 34 , 49 ]. The asymmetric unit of 1 contained one Zn(II) metal center, two pyrazinamide molecules, one water molecule, and two free nitrate anions.…”

“…Different biocompatible metallic ions (Zn(II), Mn(II) and Ag(I)) were tested in an attempt to synthesize coordination frameworks of pyrazinamide (PYR), recurring to mechanochemistry ( Scheme 1 ). The herein called compound 1 , [Zn(PYR) 2 (H 2 O)](NO 3 ) 2 , was already obtained from solution techniques (CSD refcode: HAYKUP) [ 34 , 49 ], but it was now reproduced using neat grinding. The discussion of its crystal structure is also included herein for comparison reasons.…”

“…Neat grinding successfully led to the formation of four novel compounds, 2 – 5 , and the reproduction of 1 . Even though 1 , a 1D framework with Zn(II), was previously disclosed [ 34 , 49 ], herein we proposed mechanochemistry as a sustainable alternative for the synthetic procedure. Compounds 2 – 5 were unveiled for the first time herein, but the full structural elucidation was only possible for 2 , 3 , and 4 , due to the impossibility of growing good quality single crystals of 5 .…”

Síntesis, Caracterización Y Evaluación De La Actividad Biológica De Compuestos De Coordinación De Cobalto Con Pirazinamida

“…Pirazinamida tiene cuatro átomos donadores: los nitrógenos del anillo pirazina, el oxígeno del grupo carbonilo y el nitrógeno del grupo amino, por lo tanto, tiene diferentes modos de enlace al ion metálico 13 , es decir diferentes sitios de coordinación (figura 3). En algunos complejos, la coordinación de la pirazinamida al metal ocurre a través de los nitrógenos del anillo 12 y otras veces a través del oxígeno de grupo carbonilo 14 .…”