<i>Capnocytophaga canimorsus</i> Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017

Hess, Estelle; Renzi, Francesco; Karhunen, Panu; Dol, Mélanie; Lefèvre, Adrien; Antikainen, Jenni; Carlier, Elodie; Hästbacka, Johanna; Cornelis, Guy R.

doi:10.3201/eid2412.172060

Cited by 17 publications

(15 citation statements)

References 15 publications

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“…Apart from the shared indicators, oropharyngeal pathogenic bacteria Capnocytophaga and Actinomyces were also identified as indicators of the gut microbial community type II (Figs. 1 d and 2d ) 30 , 31 . Because community types II and III often appeared in the early stage of COVID-19 (Figs.…”

Section: Resultsmentioning

confidence: 99%

Temporal association between human upper respiratory and gut bacterial microbiomes during the course of COVID-19 in adults

et al. 2021

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SARS-CoV-2 is the cause of COVID-19. It infects multiple organs including the respiratory tract and gut. Dynamic changes of regional microbiomes in infected adults are largely unknown. Here, we performed longitudinal analyses of throat and anal swabs from 35 COVID-19 and 19 healthy adult controls, as well as 10 non-COVID-19 patients with other diseases, by 16 S rRNA gene sequencing. The results showed a partitioning of the patients into 3-4 categories based on microbial community types (I-IV) in both sites. The bacterial diversity was lower in COVID-19 patients than healthy controls and decreased gradually from community type I to III/IV. Although the dynamic change of microbiome was complex during COVID-19, a synchronous restoration of both the upper respiratory and gut microbiomes from early dysbiosis towards late more diverse status was observed in 6/8 mild COVID-19 adult patients. These findings reveal previously unknown interactions between upper respiratory and gut microbiomes during COVID-19.

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Section: Resultsmentioning

confidence: 99%

Temporal association between human upper respiratory and gut bacterial microbiomes during the course of COVID-19 in adults

et al. 2021

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“…Apart from the shared indicators, oropharyngeal pathogenic bacteria Capnocytophaga and Actinomyces were also identified as indicators of the gut microbial community type II (Figs. 1d and 2d) 28,29 . Because community types II and III often appeared in the early stage of COVID-19 (Figs.…”

Section: Bacteria–bacteria Co-occurrence Networkmentioning

confidence: 99%

Temporal dynamics of human respiratory and gut microbiomes during the course of COVID-19 in adults

Zhang

et al. 2020

Preprint

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SARS-CoV-2 infects multiple organs including the respiratory tract and gut. Whether regional microbiomes are disturbed significantly to affect the disease progression of COVID-19 is largely unknown. To address this question, we performed cross-sectional and longitudinal analyses of throat and anal swabs from 35 COVID-19 adults and 15 controls by 16S rRNA gene sequencing. The results allowed a partitioning of patients into 3-4 categories (I-IV) with distinct microbial community types in both sites. Lower-diversity community types often appeared in the early phase of COVID-19, and synchronous fast restoration of both the respiratory and gut microbiomes from early dysbiosis towards late near-normal was observed in 6/8 mild COVID-19 adult patients despite they had a relatively slow clinical recovery. The synchronous shift of the community types was associated with significantly positive bacterial interactions between the respiratory tract and gut, possibly along the airway-gut axis. These findings reveal previously unknown interactions between respiratory and gut microbiomes, and suggest that modulations of regional microbiota might help to improve the recovery from COVID-19 in adult patients.

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“…Three C. canimorsus serovars (A-C) cause most human infections. 5 Hess et al first reported who determine the C. canimorsus serovar by PCR; 6 this test is not performed routinely in our laboratory, and should not be performed for our patient. It is a commensal bacterium of the oral cavities of dogs and cats.…”

Section: Discussionmentioning

confidence: 99%

An Infected Arterial Aneurysm and a Dog Bite: Think at Capnocytophaga canimorsus!

Ducours¹,

Leitao²,

Pugès³

et al. 2021

IDR

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We describe the fourth cases of arterial aneurysm consecutive to Capnocytophaga canimorsus infection in a 77-year-old man. The infection occurred after a dog bite. He presented fever. The thoracic-abdominal computed tomography angiography revealed aneurysms on the abdominal aorta, left common femoral artery, and left popliteal artery. The diagnosis was performed by a blood culture positive for Capnocytophaga canimorsus . The outcome was favorable with surgery and antibiotic therapy.

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Capnocytophaga canimorsus Capsular Serovar and Disease Severity, Helsinki Hospital District, Finland, 2000–2017

Cited by 17 publications

References 15 publications

Temporal association between human upper respiratory and gut bacterial microbiomes during the course of COVID-19 in adults

Temporal association between human upper respiratory and gut bacterial microbiomes during the course of COVID-19 in adults

Temporal dynamics of human respiratory and gut microbiomes during the course of COVID-19 in adults

An Infected Arterial Aneurysm and a Dog Bite: Think at Capnocytophaga canimorsus!

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