<i>Cannabis Indica</i>(Bhang) Extract as Preanaesthetic to Propofol Anaesthesia in Dogs

Kumar, Subodh; Dass, L. L.; Sharma, Amit

doi:10.1080/09712119.2010.9707109

Cited by 8 publications

(6 citation statements)

References 2 publications

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“…However, no significant (P>0.05) difference was recorded at any interval Hyperglycemia was also recorded after administration of propofolmidazolam (Bayan et al, 2002) and propofolbuprenorphine, propofol-meperidine and propofol-pentazocine (Anandmay, 2009) in canine. Marked hyperglycemia at 1 hrs was further supported by Kumar et al, (2010) after administration of propofol premedicated with cannabis indica (Bhang) extract in dogs.…”

Section: Resultsmentioning

confidence: 97%

Clinical and Haematobiochemical Alterations Following Administration of Tramadol as Preanaethetic Analgesic with Xylazine and Propofol Anaesthesia in Canine Ovariohysterectomy

Sharma¹,

Prasad²,

Kumar³

2017

Int.J.Curr.Microbiol.App.Sci

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Section: Resultsmentioning

confidence: 97%

Clinical and Haematobiochemical Alterations Following Administration of Tramadol as Preanaethetic Analgesic with Xylazine and Propofol Anaesthesia in Canine Ovariohysterectomy

Sharma¹,

Prasad²,

Kumar³

2017

Int.J.Curr.Microbiol.App.Sci

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“…[2] with propofolbuprenorphine in atropinized dogs. Similarly, Kumar et al (2010) [9] also reported hyperglycemia after administration of propofol premeditated with cannabis indica (Bhang) extract in dogs whereas, Pathak et al (2012) [12] reported nonsignificant variation in plasma glucose concentration after intraspinal administration of buprenorphine in buffalo calves. In the present study, the increased serum glucose level might be attributed to decreased membrane transport of glucose, decreased glucose utilization, impaired insulin activity or increased concentration of adrenocortical hormones.…”

Section: Hematological Profilesmentioning

confidence: 98%

Alternations on haemato-biochemical profiles following administration of atropine-buprenorphine-propofol anaesthesia in goats

Dewangan¹,

Maravi²,

Tiwari³

et al. 2020

Int. J. Chem. Stud.

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The study was conducted to evaluate the alternations on haemato-biochemical profiles following administration of atropine-buprenorphine-propofol anaesthesia in six healthy non-descript goats of either sex weighing between 20-25 kg by administrating atropine sulphate @ 0.04 mg/kg I/M followed by buprenorphine @ 10 mg/kg I/M and 10 min. later induction of anaesthesia with propofol @ 5mg/kg I/V. Hb, PCV and TLC showed non-significant decrease at 60 min. however, the following values showed increasing trends at different time intervals of observation and returned to near base value by 6 hrs. There was significant (P<0.05) increase in neutrophils with significant (P<0.05) decrease in lymphocyte values. Serum glucose showed significant (P<0.05) elevation at 60 min. after atropine-buprenorphinepropofol administration whereas non-significant increase in serum urea nitrogen, serum creatinine, AST and ALT were observed at different time intervals. However, these changes were within normal physiological limits. Therefore, it can be concluded that atropine-buprenorphine-propofol combination does not produce any deleterious effect on vital organs and changes remain within physiological limits, thus can be safely used in goats.

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“…On the other hand, the action of cannabinoids on 5HT-1A, 5HT-2A, and 5HT-3A receptors can increase the effects of serotonin syndrome ( 7 ). Concerning other anesthetics, studies in rats have shown that ketamine can function as an exogenous agonist of CBD, releasing anandamide ( 110 ), and propofol inhibits CB1 and CB2-mediated sympathetic responses, so its effect can be prolonged ( 111 ), as with barbiturates and alfaxalone ( 7 ).…”

Section: Study Perspectives Limitations Of Its Clinical Application A...mentioning

confidence: 99%

The role of cannabinoids in pain modulation in companion animals

et al. 2023

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The use of cannabinoids in both veterinary and human medicine is controversial for legal and ethical reasons. Nonetheless, the availability and therapeutic use of naturally occurring or synthetic phytocannabinoids, such as Δ9-tetrahydrocannabidiol and cannabidiol, have been the focus of attention in studies regarding their medical uses. This review aims to examine the role of cannabinoids in pain modulation by analyzing scientific findings regarding the signaling pathways of the endocannabinoid system and discussing the analgesic effects of synthetic cannabinoids compared to cannabinoid extracts and the extent and involvement of their receptors. In animals, studies have shown the analgesic properties of these substances and the role of the cannabinoid binding −1 (CB1) and cannabinoid binding −2 (CB2) receptors in the endocannabinoid system to modulate acute, chronic and neuropathic pain. This system consists of three main components: endogenous ligands (anandamide and 2-arachidonoylglycerol), G protein-coupled receptors and enzymes that degrade and recycle the ligands. Evidence suggests that their interaction with CB1 receptors inhibits signaling in pain pathways and causes psychoactive effects. On the other hand, CB2 receptors are associated with anti-inflammatory and analgesic reactions and effects on the immune system. Cannabis extracts and their synthetic derivatives are an effective therapeutic tool that contributes to compassionate pain care and participates in its multimodal management. However, the endocannabinoid system interacts with different endogenous ligands and neurotransmitters, thus offering other therapeutic possibilities in dogs and cats, such is the case of those patients who suffer from seizures or epilepsy, contact and atopic dermatitis, degenerative myelopathies, asthma, diabetes and glaucoma, among other inflammatory diseases. Moreover, these compounds have been shown to possess antineoplastic, appetite-stimulating, and antiemetic properties. Ultimately, the study of the endocannabinoid system, its ligands, receptors, mechanism of action, and signaling, has contributed to the development of research that shows that hemp-derived and their synthetic derivatives are an effective therapeutic alternative in the multimodal management of pain in dogs and cats due to their ability to prevent peripheral and central sensitization.

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Cannabis Indica(Bhang) Extract as Preanaesthetic to Propofol Anaesthesia in Dogs

Cited by 8 publications

References 2 publications

Clinical and Haematobiochemical Alterations Following Administration of Tramadol as Preanaethetic Analgesic with Xylazine and Propofol Anaesthesia in Canine Ovariohysterectomy

Clinical and Haematobiochemical Alterations Following Administration of Tramadol as Preanaethetic Analgesic with Xylazine and Propofol Anaesthesia in Canine Ovariohysterectomy

Alternations on haemato-biochemical profiles following administration of atropine-buprenorphine-propofol anaesthesia in goats

The role of cannabinoids in pain modulation in companion animals

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