<i>Candida spp.</i> en la microbiota intestinal de las personas con autismo: revisión sistemática

Andreo-Martínez, Pedro; García-Martínez, Nuria; Quesada-Medina, Joaquín; Sánchez-Samper, Elvira Pilar; Martínez-González, Agustín Ernesto

doi:10.33588/rn.6801.2018129

Cited by 7 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, a higher abundance of both Lactobacillus and Candida was also found in Italian children with ASD and GI symptoms compared to their control group [42]. Therefore, these results are not conclusive, and, as can be observed, there is a clear lack of investigation of the whole Fungi kingdom in children with ASD, and little is still known about the role of Candida and other types of fungi in both GI and ASD symptoms [34].…”

Section: Discussionmentioning

confidence: 99%

“…In this sense, several bibliographic reviews about GM and ASD can be found in the scientific literature. For example, Hughes et al [32] and Liu et al [33] studied the dysbiosis of GM in ASD, and Andreo-Martínez et al [34] studied the gut microbes belonging to the Fungi kingdom in people with ASD. In addition, there have been few studies that have analyzed the correlation between GM composition and GI symptoms in people with ASD.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD

Martínez-González

Andreo-Martínez

2019

Medicina

View full text Add to dashboard Cite

Background and objectives: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impaired communication, social interaction disorder, and repetitive behavior. Dysbiotic gut microbiota (GM) could be a contributing factor to the appearance of ASD, as gastrointestinal (GI) symptoms are comorbidities frequently reported in ASD. As there is a lack of reviews about the role played by GM in the GI symptoms of ASD, this work aimed to carry out a systematic review of current studies comparing the GM of children with ASD and GI symptoms with those of healthy controls in the last six years. Materials and Methods: The systematic review was performed following the PRISMA guidelines. The databases chosen were Web of Science, Scopus, PubMed, and PsycINFO, and the keywords were (gut* OR intestine* OR bowel* OR gastrointestinal*) AND (microbiota* OR microflora* OR bacteria* OR microbiome* OR flora* OR bacterial* OR bacteria* OR microorganism* OR feces* OR stool*) AND (autistic* OR autism* OR ASD*). Results: A total of 16 articles were included. Ten articles performed correlations analysis between GI symptoms and ASD. Among those 10 articles, 7 found differences between the GI symptoms present in children with ASD and healthy controls. The most common GI symptom was constipation. Among the seven articles that found differences, three performed correlations analysis between GI symptoms and gut microbe abundance. Candida, Prevotella, Streptococcus, and Veillonella showed higher and lower abundance, respectively, in children with ASD and GI symptoms in more than one article. Bacteroidetes, Firmicutes, Actinomyces, Dorea, Lactobacillus, Faecalibacterium prausnitzii, and Bacteroidetes/Firmicutes ratios showed abundance discrepancies. Conclusions: It is still too early to draw a conclusion about the gut microbes involved in GI symptoms of ASD. Future research should consider the relationship between ASD behavior, GM, and GI symptoms in a multidisciplinary way and homogenize sample characteristics.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD

Martínez-González

Andreo-Martínez

2019

Medicina

View full text Add to dashboard Cite

show abstract

“…However, a higher abundance of Lactobacillus was also found in Italian children with ASD compared to their NT group (Strati et al ., ). In conclusion, there is a clear lack of investigation of the whole Fungi kingdom in children with ASD and there is still little known about the influence of Candida and other types of fungi on both GI and ASD symptoms (Andreo‐Martínez et al ., ).…”

Section: Higher or Lower Abundance Of Gut Microbes In Asdmentioning

confidence: 97%

“…A more recent systematic review up to 2018 reported elevated abundance of Proteobacteria , Lactobacillus , Bacteroides , Desulfovibrio and Clostridium , and decreased abundance of Bifidobacterium , Blautia , Dialister , Prevotella , Veillonella and Turicibacter in children with ASD compared to healthy controls (Liu et al ., ). There are also other studies and previous reviews in scientific literature about GM and ASD (Wang et al ., ; Cao et al ., ; De Angelis et al ., ; Krajmalnik‐Brown et al ., ; Andreo‐Martínez et al ., ; Martínez‐González and Andreo‐Martínez, ). Although there have been advances in the study of GM in ASD (Ding et al ., ; Liu et al ., ), the latest review studies have not been conducted following the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses guidelines (Moher et al ., ) within the past 6 years.…”

Section: Introductionmentioning

confidence: 99%

An approach to gut microbiota profile in children with autism spectrum disorder

Andreo-Martínez

García-Martínez

Sánchez-Samper

et al. 2019

Environ Microbiol Rep

View full text Add to dashboard Cite

Summary In recent years, there has been an increase in studies on the implications of gut microbiota (GM) on the behaviour of children with autism spectrum disorders (ASD) due to a dysbiosis in GM that can trigger onset, development or progression of ASD through the microbiota–gut–brain axis. The aim of this study is to carry out a systematic review of articles from the last 6 years that analyse GM in children with ASD compared to GM in control groups. Children with ASD showed a higher abundance of Roseburia and Candida genera, and lower abundance of Dialister, Bilophila, Veillonella, Streptococcus, Coprococcus and Prevotella genera. Those differences can be attributed to factors such as different nationalities, nature of control groups, place where the sample was taken, gastrointestinal (GI) problems or bacterial detection methods. It is still too early to define a specific GM profile of children with ASD, and future studies should focus on homogenizing the characteristics of samples and control groups. Furthermore, new multicentre studies should also focus on the impact of GM on GI physiology, neurophysiology and behaviour of children with ASD, and on performing psychometric analyses of the correlation between the severity of ASD behavioural symptoms and GM profiles.

show abstract

“…Un segundo factor a considerar es la implicación de los problemas gastro-intestinales (estreñimiento, dolor abdominal, diarrea, etc.) y ciertas bacterias en los problemas emocionales y la conducta de las personas con TEA, sería el llamado eje intestino-cerebro (Andreo-Martínez, García-Martínez, & Sánchez-Samper, 2017;Andreo-Martínez, García-Martínez, Quesada, Sánchez, & Martínez-González, 2019;Ding, Taur, & Walkup, 2017). En este sentido, las alteraciones cerebrales en el TEA (p.ej.…”

unclassified

Análisis mediante Bio-Feedback, Adaptación Escolar y Intervención Neuroeducativa de un Caso de Autismo Grave

Martínez-González¹,

Gil²

2019

REV IBEROAM DIAGN EV

View full text Add to dashboard Cite

ResumenEl bio-feedback es una herramienta útil para evaluar la actividad del sistema nervioso y analizar el estado emocional de las personas con Trastorno del Espectro Autista (TEA). Existen pocos estudios que analicen las variables fisiológicas y la conducta adaptativa de las personas con TEA. El presente estudio tiene el objetivo de analizar las diferencias en la conducta agresiva, nivel de anticipación, gravedad de las conductas repetitivas, niveles de ansiedad y su relación con la adaptación escolar de un caso de autismo grave con discapacidad intelectual severa. El sujeto presenta niveles de cortisol altos y problemas en la microbiota intestinal. Los resultados indican un aumento de los niveles de ansiedad, gravedad de la conducta agresiva, estereotipias y autolesiones relacionadas con la inadaptación escolar. Se halla una disminución de respuesta fisiológica tras la intervención neuroeducativa. Futuros estudios deberán estudiar las relaciones entre variables fisiológicas, conductuales, gastro-intestinales y la eficacia de los tratamientos. AbstractBio-feedback is a useful tool for assessing the activity of the nervous system and analyzing the emotional state of people with Autism Spectrum Disorder (ASD). There are few studies that analyze the physiological variables and the adaptive behavior of people with ASD. The present study aims to analyze the differences in aggressive behavior, anticipation level, severity of repetitive behaviors, anxiety level and its relation to the school adaptation of a case of severe autism with severe intellectual disability. The participant has high levels of cortisol and problems in the intestinal microbiota. The results indicate an increase in anxiety levels, aggressive behavior, stereotypies and self-injury related to school maladjustment. There is a decrease in physiological response after the neuroeducational intervention. Future studies should study the relationships between physiological, behavioral, gastro-intestinal variables and the efficacy of treatments.

show abstract

Candida spp. en la microbiota intestinal de las personas con autismo: revisión sistemática

Cited by 7 publications

References 0 publications

The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD

The Role of Gut Microbiota in Gastrointestinal Symptoms of Children with ASD

An approach to gut microbiota profile in children with autism spectrum disorder

Análisis mediante Bio-Feedback, Adaptación Escolar y Intervención Neuroeducativa de un Caso de Autismo Grave

Contact Info

Product

Resources

About