<i>Candida Parapsilosis</i> Endocarditis Following Transcatheter Pulmonary Valve Implantation

Tan, Weiyi; Dora, Amy V; Lluri, Gentian; Aboulhosn, Jamil

doi:10.1177/2150135119883624

Cited by 3 publications

(12 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This could be the reason for the surprisingly low mortality rate of the current case series, particularly those with prosthetic valve endocarditis (PVE) [1,53,58,80,89,103,107] . However, in line with prior observations, Candida species, with a reported 40%-60% rate [44,52,57,60,69,62,94,96,123,126] , is the most frequently reported infectious agent in the current case series.…”

Section: Discussionsupporting

confidence: 89%

“…In 86 reports, 91 cases of definitive fungal IE were described. These reports involved fifteen cases with Candida parapsilosis [40][41][42][43][44][45][46][47][48][49][50][51][52][53][54] , seven cases with C. albicans [55][56][57][58][59][60][61] , three cases with C. tropicalis [62][63][64] , eight other species with Candida [65][66][67][68][69][70][71][72] , eight cases with Candida with a bacterium [73][74][75][76][77][78][79][80] , ten cases with Aspergillus fumigatus [81][82][83][84][85][86][87][88][89]…”

Section: Case Reportsmentioning

confidence: 99%

“…Matrix-Assisted Laser Desorption Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS) has been developed to sequence proteins, map biomolecules in tissues, identify microorganisms, and analyze several biochemical assays in a short time. It was used in five patients with Candida infection [52,63,66,68,72] , and in 5 patients with other species [109,111,[113][114][115][116] , but not with Aspergillus. Quantitative polymerase chain reaction (qPCR) with genetic sequencing was performed in only one patient with Candida infection [71] , three with Aspergillus infection [81,92,95] , and for several other microorganisms [112,117,122,124,125] .…”

Section: Case Reportsmentioning

confidence: 99%

“…Quantitative polymerase chain reaction (qPCR) with genetic sequencing was performed in only one patient with Candida infection [71] , three with Aspergillus infection [81,92,95] , and for several other microorganisms [112,117,122,124,125] . To document and, if necessary, treat ocular involvement, an ophthalmic examination was performed in ten patients with Candida infection [45,49,52,56,57,59,62,63,76,78] , five patients with Aspergillus [81,87,88,93,97] , and three patients with other species [113,114,124] .…”

Section: Case Reportsmentioning

confidence: 99%

See 3 more Smart Citations

“Not much room for mushrooms” in the heart: knowns and unknowns of fungal infective endocarditis

Mistiaen

2024

Vessel Plus

View full text Add to dashboard Cite

Fungal infective endocarditis is a rare but highly lethal condition. Its diagnosis is often delayed due to nonspecific symptoms, inconclusive medical imaging, and negative blood cultures. Recent reviews of cases and series over the last 5 years indicate that the condition remains rare and lethal. If fungi are identified as the causative agents in more than 5% of patient cases with infective endocarditis, it is likely that risk factors such as immune suppression or cardiac implants are probably involved. A series derived from recent case reports indicates that Candida and Aspergillus are still the main causative infectious agents, with. C parapsilosis on the rise. From these cases, diagnostic clues (frequent embolisms, ophthalmic involvement, large, mobile and friable vegetation, non-valvular cardiac manifestations) are pointing towards fungal IE. These reports, however, are not standardized and a publication bias towards rare microorganisms or towards a favorable outcome might exist. Complications might be underreported, and important data such as diagnostic delay are absent or difficult to retrieve. Pharmacologic treatment is not fully standardized. Knowledge of resistant strains in this respect is important. Statistical analysis for the effect of complications and treatment modalities on outcome shows that any result should be treated cautiously. The current series is by no means a valid substitute for a well-designed series of fungal endocarditis. However, the better outcome with Candida and patients treated with surgery confirm earlier results. An international multicentric standardized registry of cases with fungal endocarditis in order to improve the outcome of this disease is highly needed. The effect of diagnostic delay on outcome remains elusive and should be resolved.

show abstract

Section: Discussionsupporting

confidence: 89%

Section: Case Reportsmentioning

confidence: 99%

Section: Case Reportsmentioning

confidence: 99%

Section: Case Reportsmentioning

confidence: 99%

See 2 more Smart Citations

“Not much room for mushrooms” in the heart: knowns and unknowns of fungal infective endocarditis

Mistiaen

2024

Vessel Plus

View full text Add to dashboard Cite

show abstract

“…Through up-to-date review of all previous cases, 12 cases of Candida Parapsilosis complex prosthetic valve endocarditis had been reported (Table 2) [13][14][15][16][17][18][19][20][21][22][23] . Besides, two articles described outbreaks of Candida parapsilosis prosthetic valve endocarditis following cardiac surgery, including 8 dead cases and one alive case without detailed information 24,25 .…”

Section: Discussionmentioning

confidence: 99%

A case series of medically managed Candida Parapsilosis complex prosthetic valve endocarditis and literature review

Guo

Fan

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: In recent years, Candida parapsilosis is recognized as a species complex and is composed of Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis and Candida Parapsilosis complex prosthetic valve endocarditis (PVE) is rare and the survival rate is still low despite of optimal therapeutic strategies. Our paper is the first to report cases as Candida Parapsilosis complex PVE. Case presentation: A series of 4 cases of Candida Parapsilosis complex PVE from our institution was reported. Three were infected by Candida parapsilosis sensu stricto and one was infected by Candida metapsilosis. The condition of two cases got better and the other died. Conclusions: More attention should be paid to Candida Parapsilosis complex PVE and early diagnosis and prompt antibiotic therapy may play a role in the treatment for Candida Parapsilosis complex PVE

show abstract

A case series of medically managed Candida parapsilosis complex prosthetic valve endocarditis

Guo

Fan

et al. 2021

Ann Clin Microbiol Antimicrob

View full text Add to dashboard Cite

Background In recent years, Candida parapsilosis is recognized as a species complex and is composed of Candida parapsilosis sensu stricto, Candida orthopsilosis and Candida metapsilosis. Candida parapsilosis complex prosthetic valve endocarditis (PVE) is rare and the survival rate is still low despite of optimal therapeutic strategies. In our report, it is novel to report cases as Candida parapsilosis complex PVE at species and identify Candida parapsilosis using MALDI-TOF MS. Case presentation A series of 4 cases of Candida parapsilosis complex PVE from our institution was reported. Three were infected by Candida parapsilosis sensu stricto and one was infected by Candida metapsilosis. The condition of two cases got better and the other died. Conclusions More attention should be paid to Candida parapsilosis complex PVE and early diagnosis and prompt antibiotic therapy may play a role in the treatment for Candida parapsilosis complex PVE. It is recommended to identify Candida parapsilosis complex at species level and MALDI-TOF MS as an easy, fast and efficient identification method is worth promoting in clinical microbiology

show abstract

Candida Parapsilosis Endocarditis Following Transcatheter Pulmonary Valve Implantation

Cited by 3 publications

References 7 publications

“Not much room for mushrooms” in the heart: knowns and unknowns of fungal infective endocarditis

“Not much room for mushrooms” in the heart: knowns and unknowns of fungal infective endocarditis

A case series of medically managed Candida Parapsilosis complex prosthetic valve endocarditis and literature review

A case series of medically managed Candida parapsilosis complex prosthetic valve endocarditis

Contact Info

Product

Resources

About