I can see what you feel, but I can't deal with it: Impaired theory of mind in depression

Wolkenstein, Larissa; Schönenberg, Michael; Schirm, Evelyne; Hautzinger, Martin

doi:10.1016/j.jad.2011.02.010

Cited by 172 publications

(191 citation statements)

References 32 publications

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“…Visual MMN to changes in facial expressions has been reported several times in healthy participants (Astikainen, Cong, Ristaniemi, & Hietanen, 2013;Astikainen & Hietanen, 2009;Kimura, Kondo, Ohira, & Schr€ oger, 2012;Li, Lu, Sun, Gao, & Zhao, 2012;Susac, Ilmoniemi, Pihko, & Supek, 2003;Zhao & Li, 2006). Because both depression and BP are associated with abnormalities in emotion processing, and since depression affects social cognition (Wolkenstein, Sch€ onenberg, Schirm, & Hautzinger, 2011), vMMN seems to be a feasible tool to study altered emotion processing in this disorder. It is thus surprising that there is only one report on vMMN to facial expressions in depressed participants (Chang, Xu, Shi, Zhang, & Zhao, 2010).…”

Section: Mood Disordersmentioning

confidence: 99%

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Kremláček

Kreegipuu

Tales

et al. 2016

Cortex

112

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The visual mismatch negativity (vMMN) response is an event-related potential (ERP) component, which is automatically elicited by events that violate predictions based on prior events. VMMN experiments use visual stimulus repetition to induce predictions, and vMMN is obtained by subtracting the response to rare unpredicted stimuli from those to frequent stimuli. One increasingly popular interpretation of the mismatch response postulates that vMMN, similar to its auditory counterpart (aMMN), represents a prediction error response generated by cortical mechanisms forming probabilistic representations of sensory signals. Here we discuss the physiological and theoretical basis of vMMN and review thirty-three studies from the emerging field of its clinical applications, presenting a meta-analysis of findings in schizophrenia, mood disorders, substance abuse, neurodegenerative disorders, developmental disorders, deafness, panic disorder and hypertension. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensory modality and thus of vital importance in environmental information processing and response, and a modality which arguably may be more sensitive to some pathological changes. However, due to the relative infancy of research in vMMN compared to aMMN in clinical populations its potential for clinical application is not yet fully appreciated. The aim of this review and meta-analysis therefore is to present, in a detailed systematic manner, the findings from clinically-based vMMN studies, to discuss their potential impact and application, to raise awareness of this measure and to improve our understanding of disease upon fundamental aspects of visual information processing. Furthermore, we include reports on aging and maturation as they bear upon many clinically relevant conditions. Surveying the literature we found that vMMN is altered in several 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 61 62 63 64 65 66 67 68 69 70 71 72 73 74 75 76 77 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 99 100 101 102 103 104 105 106 107 108 109 110 111 112 113 114 115 116 117 118 119 120 121 122 123 124 125 126 127 128 clinical populations which is in line with aMMN findings. An important potential advantage of vMMN however is that it allows the investigation of deficits in predictive processing in cognitive domains which rely primarily on visual information; a principal sensor...

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Section: Mood Disordersmentioning

confidence: 99%

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Kremláček

Kreegipuu

Tales

et al. 2016

Cortex

112

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“…However, Bexcessive^em-pathy has been linked to the development of internalizing disorder and interpersonal guilt has been proposed to be a maladaptive form of cognitive empathy (Tone & Tully, 2014). Interestingly, Wolkenstein et al found better performance in the BReading the Mind in the Eyes test^in depressed patients compared to controls (Wolkenstein et al, 2011). Thus, reduced as well as enhanced empathy might be maladaptive.…”

Section: Discussionmentioning

confidence: 99%

“…Of note, there are some studies, which investigated empathy using the MASC and the MET. While one study did not find any deficits in depressed patients in the MASC (Wilbertz et al, 2010), others reported impaired cognitive empathy in the MASC in MDD (Wolkenstein et al, 2011). Interestingly, in the same sample performance in the 'Reading the Mind in the Eyes test' was better in MDD patients compared to controls.…”

Section: Introductionmentioning

confidence: 89%

“…Thus, we aimed to investigate whether MR blockade has the opposite effects. Because other groups have shown that stress influences performance in the MASC (Smeets et al, 2009), we decided to also test the effects of MR blockade in this task, especially as cognitive empathy in the MASC was found to be impaired in MDD (Wolkenstein et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Effects of mineralocorticoid receptor blockade on empathy in patients with major depressive disorder

Wingenfeld

Kuehl

Dziobek

et al. 2016

Cogn Affect Behav Neurosci

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Background The mineralocorticoid receptor (MR) is highly expressed in the hippocampus and prefrontal cortex and is involved in social cognition. We recently found that pharmacological stimulation of the MR enhances emotional empathy but does not affect cognitive empathy. In the current study, we examined whether blockade of the MR impairs empathy in patients with major depressive disorder (MDD) and healthy individuals. Methods In a placebo-controlled study, we randomized 28 patients with MDD without psychotropic medication and 43 healthy individuals to either placebo or 300 mg spironolactone, a MR antagonist. Subsequently, all participants underwent two tests of social cognition, the Multifaceted Empathy Test (MET) and the Movie for the Assessment of Social Cognition (MASC), measuring cognitive and emotional facets of empathy. Results In the MET, we found no significant main effect of treatment or main effect of group for cognitive empathy but a highly significant treatment by group interaction (p < 0.01). Patients had higher cognitive empathy scores compared to controls in the placebo condition but not after spironolactone. Furthermore, in the spironolactone condition reduced cognitive empathy was seen in MDD patients but not in controls.Emotional empathy was not affected by MR blockade. In the MASC, no effect of spironolactone could be revealed. Conclusion Depressed patients appear to exhibit greater cognitive empathy compared to healthy individuals. Blockade of MR reduced cognitive empathy in MDD patients to the level of healthy individuals. Future studies should further clarify the impact of MR functioning on different domains of social cognition in psychiatric patients.

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“…Juose gautos sąsajos tik tarp prastesnio sudėtingų vidinių būsenų supratimo ir depresijos simptomų, bet ne tarp vidinių būsenų atpažinimo ir depresijos (Wolkenstein, Schönenberg, Schirm, & Hautzinger, 2011;Cusi, Nazarov, MacQueen, & McKinnon, 2013). Viename tyrimų mentalizacija yra nagrinėjama kaip gebėjimas suprasti prieraišumo santykių patirtis psichikos būsenų perspektyvoje.…”

unclassified

Internalūs sunkumai ir mentalizacija paauglystėje: žvalgomasis tyrimas

Gervinskaitė-Paulaitienė¹

2016

JMPD

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I can see what you feel, but I can't deal with it: Impaired theory of mind in depression

Cited by 172 publications

References 32 publications

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Visual mismatch negativity (vMMN): A review and meta-analysis of studies in psychiatric and neurological disorders

Effects of mineralocorticoid receptor blockade on empathy in patients with major depressive disorder

Internalūs sunkumai ir mentalizacija paauglystėje: žvalgomasis tyrimas

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