I Can C Clearly Now: How EPEC Inhibits Gut Vitamin C Transport by Dysregulating SVCT

Tsiaoussis, Georgios I.; Christaki, Eirini; Apidianakis, Yiorgos

doi:10.1007/s10620-020-06594-8

Cited by 2 publications

(3 citation statements)

References 11 publications

(11 reference statements)

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“…The body regulates ascorbic acid levels via negative feedback. Elevated intracellular concentrations downregulate SVCT transporter expression on intestinal cell surfaces [27]. DHA enters cells through GLUT1, a member of the SLC2 protein family primarily transporting glucose.…”

Section: Absorption Transport and Metabolism Of Vcmentioning

confidence: 99%

The Involvement of Ascorbic Acid in Cancer Treatment

Guo,

Liao,

et al. 2024

Molecules

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Vitamin C (VC), also known as ascorbic acid, plays a crucial role as a water-soluble nutrient within the human body, contributing to a variety of metabolic processes. Research findings suggest that increased doses of VC demonstrate potential anti-tumor capabilities. This review delves into the mechanisms of VC absorption and its implications for cancer management. Building upon these foundational insights, we explore modern delivery systems for VC, evaluating its use in diverse cancer treatment methods. These include starvation therapy, chemodynamic therapy (CDT), photothermal/photodynamic therapy (PTT/PDT), electrothermal therapy, immunotherapy, cellular reprogramming, chemotherapy, radiotherapy, and various combination therapies.

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Section: Absorption Transport and Metabolism Of Vcmentioning

confidence: 99%

The Involvement of Ascorbic Acid in Cancer Treatment

Guo,

Liao,

et al. 2024

Molecules

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“…[15][16] These processes are ensured through different ways including passive diffusion, facilitated diffusion, active transport and recycling. [17][18][19] After the ingestion of AA, it is absorbed into the bloodstream. The intestinal absorption of AA has been observed to be reduced with increased intake up to a certain dose; this is due to a decrease in the expression of the sodium AA transporter sodium-dependent vitamin C transporters (SVCT).…”

Section: Ascorbic Acid Homeostasismentioning

confidence: 99%

“…AA is known to be taken up primarily into cells via SVCT 1 and 2, on the other hand, its oxidized form, dehydroascorbate (DHA), is taken up via the facilitated diffusion transporters glucose transporters (GLUTs). 15,[19][20] The AA transporter SVCT1 which is expressed primarily in intestine, liver and kidney is known to mediate the renal reabsorption of AA. Mice lacking the SVCT1 gene have been reported to increase AA fractional excretion up to 18-fold with hepatic portal AA accumulation nearly terminated; however, the intestinal absorption was mildly affected.…”

Section: Ascorbic Acid Homeostasismentioning

confidence: 99%

Ascorbic acid in cancer management – time for a second look

Ogochukwu

2023

Eur J Clin Exp Med

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Introduction and aim. Over the past decades, the hypotheses that ascorbic acid (AA) can play a role as an anti-neoplastic therapy have generated many conflicting reports. Despite the controversies, mounting evidence has shown that AA has the potential to play a role as an anti-neoplastic agent. Recent studies have unraveled its pharmacokinetics and various mechanism of action on cancer cells. This has spawned different preclinical studies with reports of good activities against various cancers. Material and methods. A review of the literature regarding ascorbic acid in the management of cancer was performed using the PubMed database. The research was limited to abstracts and available full-text articles. Analysis of the literature. Clinical trials have also demonstrated its safety and tolerability across different dosages. AA has been noted as a multitargeting agent that acts as a pro-oxidative cytotoxic agent, anti-cancer epigenetic regulator and immune modulator. AA has also been shown act synergistically with standard chemotherapy regimens in different cancers. Despite its potentials, phase III clinical trials are seriously lacking. The recent phase III VITALITY study shows that AA may play a role as an adjunct targeted therapy for ras-mutated cancers. Therefore, there is need to for more standardized clinical trials to help identify cancer subtypes and AA combination regimens that can show the most benefits. In this review, the pleiotropic mechanism of action of AA was explored as well as various preclinical and clinical studies in cancer therapy. In addition, recommendations were also made for effective strategies towards an AA and standard cancer regimens in treatment as well as future directions. Ascorbic acid has been shown to induce cell death in various cancer types through different mechanisms of action. Several clinical trials and case reports have shown its efficacy in combination chemotherapy, and the pharmacological route of action can be either intravenous or oral. However, it can impair the actions of some drugs when given in combination. Also, dosage should be determined for maximal pharmacologic action. Conclusion. Ascorbic acid has the potential to provide safe and cost-effective antineoplastic treatment option especially in combination therapy. Its potential needs to be further investigated through clinical trials.

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I Can C Clearly Now: How EPEC Inhibits Gut Vitamin C Transport by Dysregulating SVCT

Cited by 2 publications

References 11 publications

The Involvement of Ascorbic Acid in Cancer Treatment

The Involvement of Ascorbic Acid in Cancer Treatment

Ascorbic acid in cancer management – time for a second look

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