Campylobacter jejunifrom Patients with Guillain-Barré Syndrome Preferentially Expresses a GD_1a-Like Epitope

Abstract

GM 1 -and GD 1a -like ganglioside mimicry in Campylobacter jejuni lipooligosaccharide (LOS) is considered to be involved in the pathogenesis of Campylobacter-induced Guillain-Barré syndrome (GBS). Compared with gastroenteritis-related isolates, GBS-related C. jejuni isolates were strongly associated with the expression of GD 1a -like mimicry. The presence of a few genes involved in LOS ganglioside mimicry, cst-II, cgtA, and cgtB, was also associated with GBS-related strains. GD 1a -like epitope expression may be an important virulence phenotype associated with the risk of developing GBS following campylobacter infection.

Comparison ofCampylobacter jejuniLipooligosaccharide Biosynthesis Loci from a Variety of Sources

“…We surveyed 16 GBS-associated isolates and found that 14 were positive for class A1 products, whereas the other 2 isolates were positive for ganglioside-associated classes A2 and C (Table 5). This is consistent with a study by Nachamkin et al (21), who previously demonstrated a strong association of cst-II (orf7a,b), cgtA (orf5), and cgtB (orf6) with GBS isolates. It should be noted that most of the GBS-associated strains in this study (12 of 16 GBS strains) were HS:19 or HS:41, which have been shown to be genetically clonal (13,28).…”

Bioengineered bugs expressing oligosaccharide receptor mimics: Toxin-binding probiotics for treatment and prevention of enteric infections

“…Firstly, not all GBS-associated C. jejuni strains express GM1 mimics, implicating other LPS structures, particularly those with multiple sialic acid groups. [35][36][37] Moreover, a small proportion of GBS-associated strains do not express sialated ganglioside mimics at all. 38 Secondly, not all C. jejuni serotypes known to express GM1-like LPS have been associated with GBS.…”

Epidemiology ofCampylobacter jejuniIsolated from Patients with Guillain-Barré and Fisher Syndromes in Japan

“…Analysis of the genes involved in the synthesis of ganglioside-like LOS may be of great importance for clarifying which C. jejuni strains involved in the pathogenesis of GBS/FS. The presence of LOS synthesis genes (cst-II, cgtA, and cgtB) is associated statistically with GBS-related isolates (20). GQ1b ganglioside is a target molecule for IgG antibody in FS (3), and all C. jejuni strains studied that bore the GQ1b epitope had cst-II, an essential gene for production of GQ1b-like LOS (27).…”