Campylobacter jejuniBacteremia in a Liver Cirrhosis Patient and Review of Literature: A Case Study

Abstract

Campylobacter infection causes gastrointestinal symptoms such as abdominal pain or diarrhea. Occasionally, Campylobacter bacteremia affects immunocompromised patients; however, serious outcomes are known to be rare. Here, we present a case of a patient with Campylobacter bacteremia who had underlying liver cirrhosis. The patient had fever and diarrhea. These symptoms subsided after treatment with cefotaxime. Campylobacter jejuni was isolated in the blood culture after 10 days. In addition, previously reported cases of Campylobacter bacteremia in Asian countries were reviewed with respect to antimicrobial sensitivities.

Circulating bacterial peptides and linked metabolomic signatures are indicative of early mortality in pediatric cirrhosis

“…In patients with PC-S, an increase in infection in the blood and subsequent immune activation are related to gut dysbiosis. Our results were concordant with a significant increase in N. meningitides , C. jejuni , Streptococcus pneumoniae , and Bacillus licheniformis , already reported 23 24 25 26 and correlated to the severity of sepsis in patients with pediatric cirrhosis.…”

“…Sepsis nonsurvivors showed a significant increase in N. meningitides , N. multiformis , C. jejuni , Streptococcus pneumoniae , B. licheniformis , and others. The correlation of N. meningitides , C. jejuni , and B. licheniformis with the severity of liver diseases 23 24 25 26 is already documented. Moreover, cluster of orthologous group function, energy, lipid metabolism, and co-enzyme transport seen in sepsis nonsurvivors are attributed to their energy-deprived state and dysregulated lipid metabolism.…”

The First Case of Leucopenia Campylobacter Jejuni Infection in Hepatitis B Cirrhosis with Bacteremia and Peritonitis in Asia

“…A previous study showed that up to 93% of the bacteremia cases are related to the recognized risk factors of immune function decline or immunosuppression, such as chronic liver disease, human immunode ciency virus infection, malignant tumor and humoral immunode ciency [6]. Though Campylobacter bacteremia might resolve without antibiotic treatment in a normal host [4], appropriate selection of empirical antibiotics from clinicians and de nite con rmation from laboratories were of great importance to the outcome and prognosis of immunocompromised patients. In addition, the studies of bacteremia combined with spontaneous bacterial peritonitis (SBP) caused by Campylobacter were more rarely found in the database.…”

“…Hence, the signi cance of clinical suspicions of Campylobacter spp. and accurate use of antibiotics in the above patients should be emphasized, which is due to the slow growth rate of pathogens and the rapid emergence of antimicrobial agentresistant Campylobacter strains all over the world [3,4]. Liver cirrhosis caused by various hepatitis can lead to the decline of human immune function, which may provide an opportunity for bacterial invasion.…”