<i>C‐MYC</i> rearrangement may induce an aggressive phenotype in anaplastic lymphoma kinase positive anaplastic large cell lymphoma: Identification of a novel fusion gene <i>ALO17/C‐MYC</i>

Moritake, Hiroshi; Shimonodan, Hidemi; Marutsuka, Kousuke; Kamimura, Sachiyo; H, Kojima; Nunoi, Hiroyuki

doi:10.1002/ajh.21887

Cited by 30 publications

(20 citation statements)

References 27 publications

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“…Rnf213 and Htr3b were both downregulated in the GL group. Rnf213 encodes a protein with ring finger domain and it is involved in chromosomal arrangement with c-Myc and ALK in anaplastic large cell lymphoma, and with SLC26A11 in chronic myeloid leukemia [48][49][50].…”

Section: Discussionmentioning

confidence: 99%

Lipidomic fatty acid profile and global gene expression pattern in mammary gland of rats that were exposed to lard-based high fat diet during fetal and lactation periods associated to breast cancer risk in adulthood

Andrade

Assis

Jin

et al. 2015

Chemico-Biological Interactions

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The persistent effects of animal fat consumption during pregnancy and nursing on the programming of breast cancer risk among female offspring were studied here. We have previously found that female offspring of rat dams that consumed a lard-based high-fat (HF) diet (60% fat-derived energy) during pregnancy, or during pregnancy and lactation, were at a reduced risk of developing mammary cancer. To better understand the unexpected protective effects of early life lard exposure, we have applied lipidomics and nutrigenomics approaches to investigate the fatty acid profile and global gene expression patterns in the mammary tissue of the female offspring. Consumption of this HF diet during gestation had few effects on the mammary tissue fatty acids profile of young adult offspring, while exposure from gestation throughout nursing promoted significant alterations in the fatty acids profile. Major differences were related to decreases in saturated fatty acids (SFA) and increases in omega-6 polyunsaturated fatty acids (PUFAs), monounsaturated fatty acids (MUFAs) and conjugated linolenic acid (CLA) concentrations. In addition several differences in gene expression patterns by microarray analysis between the control and in utero or in utero and during lactation HF exposed offspring were identified. Differential dependency network (DDN) analysis indicated that many of the genes exhibited unique connections to other genes only in the HF offspring. These unique connections included Hrh1-Ythdf1 and Repin1-Elavl2 in the in utero HF offspring, and Rnf213-Htr3b and Klf5-Chrna4 in the in utero and lactation HF offspring, compared with the control offspring. We conclude that an exposure to a lard-based HF diet during early life changes the fatty acid profile and transcriptional network in mammary gland in young adult rats, and these changes appear to be consistent with reduced mammary cancer risk observed in our previous study.

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Section: Discussionmentioning

confidence: 99%

Lipidomic fatty acid profile and global gene expression pattern in mammary gland of rats that were exposed to lard-based high fat diet during fetal and lactation periods associated to breast cancer risk in adulthood

Andrade

Assis

Jin

et al. 2015

Chemico-Biological Interactions

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“…on May 10, 2018. by guest www.bloodjournal.org From RNF213 itself may play an important role in oncogenesis. 55,56 It is important to note that most CNAs were consistent with heterozygous loss, and classical tumor suppressors require biallelic loss for oncogenesis. However, these losses could lead to pathway modulation due to altered protein levels or the creation of dominant negatives by partial gene loss.…”

Section: Discussionmentioning

confidence: 99%

The genomic landscape of Waldenström macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis

Hunter

Liu

Yang

et al. 2014

Blood

402

366

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“…Using deep RNA sequencing, our group recently identified a novel TRAF1-ALK fusion in an ALCL patient with cytoplasmic ALK immunoreactivity only [9]. Rearrangements of the MYC gene, frequently detected in high-grade B-cell lymphomas, have been reported in 3 cases of ALK-positive ALCL [10–12]. All 3 patients with dual ALK and MYC rearrangements demonstrated an aggressive clinical course, with systemic and extranodal presentation, early tumor relapse, and bone marrow involvement during the course of the disease.…”

Section: Alk Rearrangementsmentioning

confidence: 99%

Genetics of anaplastic large cell lymphoma

Zeng

Feldman

2015

Leukemia & Lymphoma

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Anaplastic large cell lymphoma (ALCL) comprises a group of T-cell non-Hodgkin lymphomas unified by common morphologic and immunophenotypic characteristics, but with a spectrum of clinical presentations and behaviors. Early identification of anaplastic lymphoma kinase (ALK) gene rearrangements in some ALCLs led to recognition of ALK as an important diagnostic and prognostic biomarker, and a key driver of ALCL pathobiology. Rearrangements and other genetic abnormalities of ALK subsequently were identified in diverse other human malignancies. Recent clinical, pathologic, and genetic data have begun to shed light on ALK-negative ALCLs, revealing significant heterogeneity within this more ill-defined entity.

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C‐MYC rearrangement may induce an aggressive phenotype in anaplastic lymphoma kinase positive anaplastic large cell lymphoma: Identification of a novel fusion gene ALO17/C‐MYC

Cited by 30 publications

References 27 publications

Lipidomic fatty acid profile and global gene expression pattern in mammary gland of rats that were exposed to lard-based high fat diet during fetal and lactation periods associated to breast cancer risk in adulthood

Lipidomic fatty acid profile and global gene expression pattern in mammary gland of rats that were exposed to lard-based high fat diet during fetal and lactation periods associated to breast cancer risk in adulthood

The genomic landscape of Waldenström macroglobulinemia is characterized by highly recurring MYD88 and WHIM-like CXCR4 mutations, and small somatic deletions associated with B-cell lymphomagenesis

Genetics of anaplastic large cell lymphoma

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