C₃‐Symmetric Pt₃Pd₃ Purine Vases Based on a Metal Coordination Motif Involving the Pyrimidinic N1 and N3 Sites

Beyond Sole Models for the First Steps of Pt-Dna Interactions: Fundamental Properties of Mono(Nucleobase) Adducts of Ptii Coordination Compounds

“…The cone structure of this C 3 -symmetric compound (Fig. 23), and its positive charge is ideally suited to act as a receptor for tetrahedral anions, as experimentally confirmed [238].…”

“…Such compounds were synthesized by initially blocking the N7 position of 9RGH with (dien)Pt II , followed by Pt cross-linking its N1 site with a second nucleobase, and subsequent removal of (dien)Pt II with the strong nucleophile cyanide [233]. Other examples include dinuclear (N7,N1) [234,235] and trinuclear (N7,N1,N3) Pt II complexes [236], heteronuclear ones involving O6 as another metal binding site [233,237] and a cyclic C 3 -symmetric species derived from [Pt(NH 3 ) 3 (9EtHxH-N7)] 2+ and (en)Pd II [238]. This latter product combines lessons learnt from simple model compounds -acidification of N1H by Pt coordination to N7, subsequent coordination of Pd II to N1 and then to N3-to eventually lead to a Pt 3 /Pd 3 product.…”