<i>Byrd's Line: A Natural History</i>. By Stephen C. Ausband. Charlottesville: University of Virginia Press, 2002. ix + 187 pp. Illustrations, maps, bibliography, index. Cloth $22.95

Ausband, Stephen Conrad

doi:10.2307/3985963

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Nephrogenic Systemic Fibrosis

Bangsgaard¹,

Marckmann²,

Rossen³

et al. 2009

Arch Dermatol

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Background: Nephrogenic systemic fibrosis (NSF) is a serious disease that occurs in patients with severe renal disease and is believed to be caused by gadoliniumcontaining contrast agents. A detailed description of the late skin manifestations of NSF is important to help dermatologists and nephrologists recognize the disease. Observations: We studied 17 patients with NSF late in the disease. All patients showed epidermal atrophy and hairlessness of the affected regions, primarily the lower legs. Affected areas were symmetrically distributed and hyperpigmented in most cases. Eleven patients showed confluent dermal plaques with thickening and hardening. In contrast, 3 patients presented with wrinkled, redundant skin as seen in cutis laxa. Patients with NSF had significantly poorer scores than control patients on the Daily Life Quality Index (mean [SD], 11. 4 [7.4] vs 1.5 [2. 3]; PϽ.001). Conclusions: This descriptive case series of patients with NSF gives a detailed clinical picture of the skin manifestations late in the disease. It demonstrates that the clinical picture in the late stage has a varied presentation and that NSF has a significant effect on the quality of life.

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