<i>Burkholderia pseudomallei</i>Sequence Type 562 in China and Australia

Hai, Chen; Xia, Linlin; Zhu, Xiong; Li, Wei; Du, Xiaoli; Duo-rong, WU; Hai, Rong; Shen, Xiantao; Liang, Ying; Cai, Hong; Zheng, Xiaobo

doi:10.3201/eid2101.140156

Cited by 19 publications

(24 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Generally, ST46 and ST50 were grouped as a single CC, ST55 and ST58 in another CC, the new STs (ST1345, ST1346, ST1347, ST1350, ST1351) fell into two additional CCs. A UPGMA tree based on this study data and reference ST36 and ST109 (Australia), ST70 and ST93 (Thailand) and ST246 (New Guinea) showed significant linkage of isolates from China with those from Thailand, but only a weak relationship with strains from Australia as illustrated by ST1090 and ST109 (Australia) and between ST1349 (present study) and ST562, which was recently reported to be shared between strains from China and Australia [12]. ST1348, ST246, and ST36 were clustered together, suggesting a possible correlation between B. pseudomallei from Australia and New Guinea strains, and these three STs were similar to those recently identified in China, including ST1094, ST1095, ST1106, and ST1341, which taken together might suggest a relationship between strains from Australia and China (Fig.…”

Section: Mlst Analysissupporting

confidence: 57%

Multilocus sequence typing of 102 Burkholderia pseudomallei strains isolated from China

Yao

Zhu

et al. 2016

Epidemiol. Infect.

View full text Add to dashboard Cite

The phylogenetic and epidemiological relationships of 102 Burkholderia pseudomallei clinical isolates from different geographical and population sources in China were investigated by multilocus sequence typing (MLST). The MLST data were analysed using the e-BURST algorithm, and an unweighted pair-group method with arithmetic mean dendrogram was constructed based on the pair-wise differences in the allelic profiles of the strains. Forty-one sequence types (STs) were identified, of which eight were novel (ST1341, ST1345, ST1346, ST1347, ST1348, ST1349, ST1350, ST1351). No geographical-specific or host population-specific phylogenetic lineages were identified. ST46, ST50, ST55, ST58, ST70 and ST1095 predominated, but ~44% of isolates were assigned to 45 STs illustrating high genetic diversity in the strain collection. Additionally, the phylogenetic relationships of the dominant STs in China showed significant linkeage with B. pseudomallei isolates from Thailand. Analysis of the gmhD allele suggests high genetic variation in B. pseudomallei in China.

show abstract

Section: Mlst Analysissupporting

confidence: 57%

Multilocus sequence typing of 102 Burkholderia pseudomallei strains isolated from China

Yao

Zhu

et al. 2016

Epidemiol. Infect.

View full text Add to dashboard Cite

show abstract

“…As previously shown ( 33 , 35 , 38 , 39 ), we observed a clear distinction between Australasian (red or green) and Asian (blue) B. pseudomallei strains, which was supported by a bootstrap value of 74%. The separation of the Australasian and Asian B. pseudomallei clades is due to the restricted dispersal of B. pseudomallei between these two geographic regions, with ST-562 being the only example where a recent overlap between these two regions has been confirmed ( 39 , 40 ). The African (pink) and South American (gold) strains all reside on a separate, highly supported (bootstrap value = 100%) branch within the Asian clade.…”

Section: Resultsmentioning

confidence: 99%

Phylogenomic Analysis Reveals an Asian Origin for African Burkholderia pseudomallei and Further Supports Melioidosis Endemicity in Africa

Sarovich

Garin

Smet

et al. 2016

mSphere

View full text Add to dashboard Cite

Sporadic melioidosis cases have been reported in the African mainland and Indian Ocean islands, but until recently, these regions were not considered areas where B. pseudomallei is endemic. Given the high mortality rate of melioidosis, it is crucial that this disease be recognized and suspected in all regions of endemicity. Previous work has shown that B. pseudomallei originated in Australia, with subsequent introduction into Asia; however, the precise origin of B. pseudomallei in other tropical regions remains poorly understood. Using whole-genome sequencing, we characterized B. pseudomallei isolates from Madagascar and Burkina Faso. Next, we compared these strains to a global collection of B. pseudomallei isolates to identify their evolutionary origins. We found that African B. pseudomallei strains likely originated from Asia and were closely related to South American strains, reflecting a relatively recent shared evolutionary history. We also identified substantial genetic diversity among African strains, suggesting long-term B. pseudomallei endemicity in this region.

show abstract

“…However, a few exceptions have been more recently reported; in one study, ST105 and ST849 were shared STs between Australia and Cambodia and both STs were isolated from patients from both countries [ 40 ]. Another study reported the isolation of ST562 from Australia and China [ 41 ].…”

Section: Discussionmentioning

confidence: 99%

Multilocus sequence types of clinical Burkholderia pseudomallei isolates from peninsular Malaysia and their associations with disease outcomes

et al. 2018

View full text Add to dashboard Cite

BackgroundPrevious studies on the Burkholderia pseudomallei genetic diversity among clinical isolates from melioidosis-endemic areas have identified genetic factors contributing to differential virulence. Although it has been ruled out in Australian and Thai B. pseudomallei populations, it remains unclear whether B. pseudomallei sequence types (STs) correlate with disease in Malaysian patients with melioidosis.MethodsIn this study, multi-locus sequence typing (MLST) was performed on clinical B. pseudomallei isolates collected from Kelantan state of Malaysia, patients’ clinical data were reviewed and then genotype-risk correlations were investigated.ResultsGenotyping of 83 B. pseudomallei isolates revealed 32 different STs, of which 13(40%) were novel. The frequencies of the STs among the 83 isolates ranged from 1 to 12 observations, and ST54, ST371 and ST289 were predominant. All non-novel STs reported in this study have also been identified in other Asian countries. Based on the MLST data analysis, the phylogenetic tree showed clustering of the STs with each other, as well as with the STs from Southeast Asia and China. No evidence for associations between any of B. pseudomallei STs and clinical melioidosis presentation was detected. In addition, the bacterial genotype clusters in relation with each clinical outcome were statistically insignificant, and no risk estimate was reported. This study has expanded the data for B. pseudomallei on MLST database map and provided insights into the molecular epidemiology of melioidosis in Peninsular Malaysia.ConclusionThis study concurs with previous reports concluding that infecting strain type plays no role in determining disease presentation.

show abstract

Burkholderia pseudomalleiSequence Type 562 in China and Australia

Cited by 19 publications

References 10 publications

Multilocus sequence typing of 102 Burkholderia pseudomallei strains isolated from China

Multilocus sequence typing of 102 Burkholderia pseudomallei strains isolated from China

Phylogenomic Analysis Reveals an Asian Origin for African Burkholderia pseudomallei and Further Supports Melioidosis Endemicity in Africa

Multilocus sequence types of clinical Burkholderia pseudomallei isolates from peninsular Malaysia and their associations with disease outcomes

Contact Info

Product

Resources

About