<i>Burkholderia cepacia</i>—An Uncommon Cause of Exit-Site Infection in a Peritoneal Dialysis Patient

Yap, Desmond Y H; Choy, Cindy B.Y.; Mok, Maggie M Y; Wong, Tin Kan; Chan, Tak Mao

doi:10.3747/pdi.2013.00090

Cited by 7 publications

(10 citation statements)

References 5 publications

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“…Generally speaking, tobramycin and amikacin are more active on Pseudomonas species than gentamicin. In recent years, catheter-related infections caused by Burkholderia cepacia (197,198) and non-tuberculous mycobacteria (199,200) have been increasingly reported, and their treatment should be individualized.…”

Section: Modification Of Antibiotic Regimenmentioning

confidence: 99%

“…calcium, iron, or zinc preparations), sucralfate, magnesiumaluminum antacids, or milk, chelation and reduced quinolone absorption may occur. Administration of the quinolone should therefore be separated from these drugs by at least 2 hours (197,198) and non-tuberculous mycobacteria (199,200) have been increasingly reported, and their treatment should be individualized.…”

Section: Modification Of Antibiotic Regimenmentioning

confidence: 99%

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ISPD Catheter-Related Infection Recommendations: 2017 Update

et al. 2017

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Section: Modification Of Antibiotic Regimenmentioning

confidence: 99%

Section: Modification Of Antibiotic Regimenmentioning

confidence: 99%

ISPD Catheter-Related Infection Recommendations: 2017 Update

et al. 2017

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“…For instance, some studies have suggested that the use of mupirocin or gentamicin ointment may predispose patients to fungal exit site infections [7,8]. There is also emergence of exotic organisms such as atypical mycobacteria, corynebacteria as well as Burkholderia species to cause ESI [2,[9][10][11]. Furthermore, the development of antibiotics resistance remains an important concern in the management of ESI.…”

Section: Pathogenesis and Microbiology Of Exit Site Infection In Perimentioning

confidence: 99%

“…The emergence of extended spectrum β-lactamase (ESBL)-producing Gram-negative bacilli is an escalating threat in the management of ESI. Other emerging pathogens to cause ESI include Burkholderia cepacia, which is a hardy nonfermenting Gram-negative organism [10,11]. Its intrinsic resistance to multiple commercially available antibiotics and easy transmissibility renders it a growing problem in dialysis units.…”

Section: Other Gram-negative Organisms and Anaerobesmentioning

confidence: 99%

Diagnosis and Management of Exit Site Infection in Peritoneal Dialysis Patients

Yap¹,

Yip²

2016

Some Special Problems in Peritoneal Dialysis

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Exit site infection ESI is an important clinical problem in peritoneal dialysis PD patients and is a significant cause of peritonitis and catheter loss. While most ESIs are caused by skin commensals, rising incidence of atypical and resilient organisms such as mycobacteria, Pseudomonas and Burkholderia species has been observed. The diagnosis and management of these emerging pathogen remain difficult and poorly defined. This chapter highlights the evaluation and management of ESI in PD patients. The clinical features, microbiology, and ultrasonographic findings are discussed. The general and specific management of ESI due to different organisms will also be elaborated. ESI is usually a clinical diagnosis, but the use of bedside ultrasound can help assess for any collection around the cuff and tunnel tract involvement. Topical prophylaxis remains an effective way to prevent ESI. While the majority ESIs are related to skin flora and can be managed successfully by topical or systemic antimicrobials, clinicians should be alert to the emergence of resistant and atypical microorganisms. Surgical treatment should be reserved for ESI refractory to medical treatment or those with associated peritonitis.

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“…Bcc is a group of at least 24 closely related bacterial species that attracted the attention of various research groups worldwide due to their ability to cause problematic, difficult-to-eradicate, and often fatal infections among cystic fibrosis patients [20][21][22][23]. In addition, recent reports also mention an increasing number of infections caused by these bacteria in non-cystic fibrosis patients, including hospitalized patients suffering from other malignancies such as cancer, hemodialysis, and others [24][25][26][27]. These bacteria possess large genomes arranged in multiple replicons with high plasticity and complex regulatory mechanisms of gene expression [28].…”

Section: Introductionmentioning

confidence: 99%

Comparative Genomics and Evolutionary Analysis of RNA-Binding Proteins of Burkholderia cenocepacia J2315 and Other Members of the B. cepacia Complex

Feliciano

Seixas

Pita

et al. 2020

Genes

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RNA-binding proteins (RBPs) are important regulators of cellular functions, playing critical roles on the survival of bacteria and in the case of pathogens, on their interaction with the host. RBPs are involved in transcriptional, post-transcriptional, and translational processes. However, except for model organisms like Escherichia coli, there is little information about the identification or characterization of RBPs in other bacteria, namely in members of the Burkholderia cepacia complex (Bcc). Bcc is a group of bacterial species associated with a poor clinical prognosis in cystic fibrosis patients. These species have some of the largest bacterial genomes, and except for the presence of two-distinct Hfq-like proteins, their RBP repertoire has not been analyzed so far. Using in silico approaches, we identified 186 conventional putative RBPs in Burkholderia cenocepacia J2315, an epidemic and multidrug resistant pathogen of cystic fibrosis patients. Here we describe the comparative genomics and phylogenetic analysis of RBPs present in multiple copies and predicted to play a role in transcription, protein synthesis, and RNA decay in Bcc bacteria. In addition to the two different Hfq chaperones, five cold shock proteins phylogenetically close to E. coli CspD protein and three distinct RhlE-like helicases could be found in the B. cenocepacia J2315 genome. No RhlB, SrmB, or DeaD helicases could be found in the genomes of these bacteria. These results, together with the multiple copies of other proteins generally involved in RNA degradation, suggest the existence, in B. cenocepacia and in other Bcc bacteria, of some extra and unexplored functions for the mentioned RBPs, as well as of alternative mechanisms involved in RNA regulation and metabolism in these bacteria.

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Burkholderia cepacia—An Uncommon Cause of Exit-Site Infection in a Peritoneal Dialysis Patient

Cited by 7 publications

References 5 publications

ISPD Catheter-Related Infection Recommendations: 2017 Update

ISPD Catheter-Related Infection Recommendations: 2017 Update

Diagnosis and Management of Exit Site Infection in Peritoneal Dialysis Patients

Comparative Genomics and Evolutionary Analysis of RNA-Binding Proteins of Burkholderia cenocepacia J2315 and Other Members of the B. cepacia Complex

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