bullwinkleandsharkregulate dorsal-appendage morphogenesis inDrosophilaoogenesis

Tran, David H.; Berg, Celeste A.

doi:10.1242/dev.00854

Cited by 49 publications

(44 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The current published data support the hypothesis that BWK may regulate morphogenesis via a signaling pathway that is neither dependent on GRK/EGFR (Rittenhouse and Berg, 1995) nor on the JNK or DPP signaling pathways, assuming the involvement of another, yet unknown pathway (Tran and Berg, 2003). The results presented here suggest that spoon may participate in this pathway.…”

Section: Figsupporting

confidence: 85%

See 1 more Smart Citation

Drosophila female sterile mutation spoonbill interferes with multiple pathways in oogenesis

Neuman-Silberberg

2007

Genesis

View full text Add to dashboard Cite

spoonbill is a Drosophila female-sterile mutation, which displays a range of eggshell and egg chamber patterning defects. Previous analysis has shown that the mutation interfered with the function of two major signaling pathways, GRK/EGFR and DPP. In this report, the nature of spoonbill was further investigated to examine whether it was associated with additional pathways in oogenesis. Clonal analysis, presented here, demonstrated that most of the aberrant phenotypes associated with spoonbill were dependent on a mutant germline. Nevertheless, SPOONBILL may function also in the soma to ensure proper polarization and migration of the border-cell-cluster. Further, genetic interaction studies implicated spoonbill in additional unrelated pathways such as the one(s) involved in actin polymerization/depolymerization. Based on the previous data and the results presented here, it is anticipated that spoonbill may encode a multifunctional protein that perhaps coordinately regulated the activity of multiple signaling pathways during oogenesis.

show abstract

Section: Figsupporting

confidence: 85%

“…The results presented here suggested that in addition to its roles in the GRK/EGFR and DPP pathways, spoon may be involved in other unrelated pathways including pathways involved in actin polymerization, BC migration, and additional pathways such as the bwk/shark pathway (Tran and Berg, 2003) and cup. …”

Section: Discussionmentioning

confidence: 82%

Drosophila female sterile mutation spoonbill interferes with multiple pathways in oogenesis

Neuman-Silberberg

2007

Genesis

View full text Add to dashboard Cite

show abstract

“…It may occur via Shark, a kinase that has been shown to interact with both Drpr and JNK in Drosophila (Fernandez et al, 2000;Tran and Berg, 2003;Ziegenfuss et al, 2008). Another candidate is Rac1, which can act upstream of JNK and may act downstream of Drpr (Kinchen et al, 2005).…”

Section: Discussionmentioning

confidence: 99%

Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells

et al. 2012

View full text Add to dashboard Cite

SUMMARYThe efficient removal of dead cells is an important process in animal development and homeostasis. Cell corpses are often engulfed by professional phagocytes such as macrophages. However, in some tissues with limited accessibility to circulating cells, engulfment is carried out by neighboring non-professional phagocytes such as epithelial cells. Here, we investigate the mechanism of corpse clearance in the Drosophila melanogaster ovary, a tissue that is closed to circulating cells. In degenerating egg chambers, dying germline cells are engulfed by the surrounding somatic follicular epithelium by unknown mechanisms. We show that the JNK pathway is activated and required in engulfing follicle cells. We find that the receptor Draper is also required in engulfing follicle cells, and activates the JNK pathway. Overexpression of Draper or the JNK pathway in follicle cells is sufficient to induce death of the underlying germline, suggesting that there is coordination between the germline and follicular epithelium to promote germline cell death. Furthermore, activation of JNK bypasses the need for Draper in engulfment. The induction of JNK and Draper in follicle cells occurs independently of caspase activity in the germline, indicating that at least two pathways are necessary to coordinate germline cell death with engulfment by the somatic epithelium.

show abstract

“…Concurrently, the Gurken ligand concentrated in the anterodorsal corner of the oocyte signals to the main-body FCs associated with this region, which then adopt a dorsal fate (for reviews, see Dobens and Raftery, 2000;Dorman et al, 2004). One of the consequences of this dorsal signaling is the formation of two dorsolateral patches of FCs that migrate anteriorly over the surface of the SCs, where they form two elongated tubes (Tran and Berg, 2003;Dorman et al, 2004). During choriogenesis these tubes participate in the formation of dorsal (respiratory) appendages of the eggshell.…”

Section: Introductionmentioning

confidence: 99%

Differing strategies of patterning of follicular cells in higher and lower brachycerans (Diptera: Brachycera)

Tworzydło

Jabłońska

Kisiel

et al. 2005

Genesis

View full text Add to dashboard Cite

In all higher dipterans (Brachycera), including the fruitfly, Drosophila melanogaster, each egg chamber (ovarian follicle) consists of a group (clone) of germ cells (one oocyte and 15 accompanying nurse cells) that is surrounded by a layer of somatic mesodermal follicular cells (FCs). As oogenesis progresses the initially uniform FCs diversify into several morphologically and functionally distinct subpopulations. In D. melanogaster some of these subpopulations, e.g., border, centripetal, and dorsolateral cells, undertake coordinated migration or rearrangement over the surface of the germ cells. During the final stages of oogenesis these subpopulations participate in the formation of a complex, regionally specialized eggshell. In representatives of lower brachycerans (Orthorrhapha), only FCs that undertake active, directed migration are the border cells. These cells originate at the anterior pole of the ovarian follicle and migrate between the nurse cells to the anterior pole of the oocyte. Reduced motility of FCs in lower brachycerans results in the absence of certain FC subpopulations in their egg chambers and subsequent simplicity of their eggshells. We found that the lack of some FC subpopulations coincided with the appearance of lamellipodium-like protrusions of the oocyte. These protrusions penetrated between the apposing membranes of nurse and FCs and partially enveloped the nurse cell compartment. Analysis of whole-mount preparations stained with rhodamine-conjugated phalloidin revealed that the protrusions contained microfilaments and that their tips were equipped with actin-rich filopodium-like processes. We also found that in some lower brachycerans (representatives of the family Rhagionidae), the FCs located at the posterior pole of the oocyte, became enlarged and morphologically similar to the anterior border cells. These findings indicate that in higher dipterans the processes leading to the formation of a functional egg are variable and often markedly different from those in the model organism, D. melanogaster.

show abstract

bullwinkleandsharkregulate dorsal-appendage morphogenesis inDrosophilaoogenesis

Cited by 49 publications

References 57 publications

Drosophila female sterile mutation spoonbill interferes with multiple pathways in oogenesis

Drosophila female sterile mutation spoonbill interferes with multiple pathways in oogenesis

Draper acts through the JNK pathway to control synchronous engulfment of dying germline cells by follicular epithelial cells

Differing strategies of patterning of follicular cells in higher and lower brachycerans (Diptera: Brachycera)

Contact Info

Product

Resources

About